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How to Sequence 1000 Human Genomes Efficiently

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If you have a question about this talk, please contact Professor Nicholas S. Manton.

DNA sequencing output has scaled superexponentially for three decades, with average doubling time since 1980 of 16 months, and more rapid doubling recently. We have reached the point where it is now possible to sequence hundreds of human genomes in order to develop a much more complete picture of human genetic variation that will underpin future research in human genetics. The design of this experiment, and analysis of the data, need to take account of the pattern of genetic differences shared between individuals, as well as efficient sequence matching and statistical analysis. I will discuss recently developed methods based on Ancestral Recombination Graphs (the data structure underlying the coalescent with recombination) and how we are using them to analyse data from the 1000 Genomes Project , and introduce some related problems.

This talk is part of the CMS Colloquia series.

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