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Dynamics of cell cycle transitions

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If you have a question about this talk, please contact Dr Fabien Petitcolas.

Abstract: The eukaryotic cell cycle is distributed into four phases (G1, S, G2, M). The transitions between these phases control important cell cycle events like DNA replication, mitosis and cell division. These processes have to happen in correct order and only once per cell cycle. The special dynamics of the underlying molecular network is responsible to make these transitions irreversible. Positive feedback regulations ensure that the transitions happen only once and feed-forward loops determine the correct timing of these events. The details of these molecular regulatory loops and the intricacy of their dynamics will be presented.

References:
  • Novak B, Tyson JJ, Gyorffy B, Csikasz-Nagy A. Irreversible cell-cycle transitions are due to systems-level feedback, Nat Cell Biol 2007; 9:724-728.
  • Csikasz-Nagy A, Kapuy O, Toth A, Pal C, Jensen LJ, Uhlmann F, Tyson JJ, Novak B. Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation. Mol Sys Biol 2009; in press.

Biography: Short bio Attila Csikász-Nagy was born in Budapest, Hungary on 20 June 1974. He received an M.S. degree in 1998 (thesis title: “Mathematical models for the evolution of eukaryotic cell cycle”), and a PhD degree in 2000 (thesis title: “Mathematical models of the budding yeast cell cycle”) from the Budapest University of Technology and Economics under the guidance of Prof. Béla Novák. He spent several months in 1997 and 1999 as a visiting scholar in Prof. John Tyson’s lab (Virginia Tech, USA ), modeling the Start and exit-of-mitosis transitions of the budding yeast cell cycle. The focus of his graduate work was studying how various eukaryotic cells control their cell cycle progression in time, using coupled ordinary differential equations (ODE) and bifurcation analyses. Since the process of cell growth and division is orchestrated in space as well as in time, Attila became interested in how fission yeast cells obtain their rod shape, grow in a polarized fashion (they first grow in one end and then switch to grow in both ends) and then make a septum in the middle. From 2000-2004, he worked with Dr. Novák as a postdoctoral fellow to study microtubule dynamics and morphogenesis in fission yeast, using reaction-diffusion equations. In 2004, he spent a year as a postdoctoral fellow with Dr. Tyson to build a generic model of cell cycle regulation that is applicable to a wide spectrum of eukaryotes from budding yeast, fission yeast, and Xenopus embryos up to mammalian cells. In 2005, he joined the Molecular Network Dynamics Research Group of the Hungarian Academy of Sciences, led by Béla Novák. He was an assistant professor from 2005-2007 at the Budapest University of Technology and Economics, where he taught courses in cell biology and microbial physiology. During his career, Attila worked out mathematical models of cell cycle regulation in various eukaryotic organisms and analyzed these models with tools of non-linear dynamics. His publications have appeared in leading journals of the field, and Attila is a regular reviewer for journals such as the Journal of Theoretical Biology, Molecular Systems Biology, BMC Systems Biology, Physical Review Letters, PLoS Computational Biology, IET Systems Biology and other related journals. Attila joined CoSBi in June 2007.

This talk is part of the CoSBi Computational and Systems Biology Series series.

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