University of Cambridge > Talks.cam > BSS Formal Seminars > Understanding shape and traction of adherent cells

  Browse A-Z

Log in

Cambridge users (raven)details Other usersdetails No account?details

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

Understanding shape and traction of adherent cells

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Jurij Kotar.

Tissue cells strongly adapt their cytoskeletal architectures and shapes to environmental cues, including the geometry of the adhesive ligand distribution and the stiffness of the microenvironment. During the last decade, it has been shown that the same physical factors also have a large impact on cellular function, including cell proliferation and differentiation. A growing body of evidence suggests that these decisions are indeed guided by cell shape, including forces acting at sites of adhesion. Using microcontact printing, quantitative image processing and theoretical modelling, we demonstrate that cell shape is mainly determined by the physics of actively contracting cable networks. Our theory can also be used to calculate forces at sites of adhesion. Experimentally these forces can be measured on soft elastic substrates with high resolution traction force microscopy, which we apply both to stationary and migrating cells. In the future, these advances will be integrated to achieve a comprehensive and quantitative understanding of cell adhesion.

This talk is part of the BSS Formal Seminars series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

CRASSH-Festival of Ideas Multilingualism and Exchange in the Ancient and Medieval World St John's Women's Society Talks

Other talks

Liver Regeneration in the Damaged Liver Reconciling centennial-scale climate variation during the last millennium in reconstructions and simulations Modulating developmental signals allows establishment of cultures of expanded potential stem cells Eurostar with Philippe Mouly Skyrmions, Quantum Graphs and Carbon-12 A new proposal for the mechanism of protein translocation Immigration and Freedom 'Walking through Language – Building Memory Palaces in Virtual Reality' 'Honouring Giulio Regeni: a plea for research in risky environments' An SU(3) variant of instanton homology for webs Art speak
 

© 2006-2024 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity