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Computational Neuroscience Journal Club

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If you have a question about this talk, please contact Guillaume Hennequin.

Daniel McNamee will cover

  • Orbitofrontal Cortex Encodes Memories within Value-Based Schemas and Represents Contexts That Guide Memory Retrieval
  • A Farovik, R J Place, S McKenzie, B Porter, C E Munro, and H Eichenbaum
  • J Neurosci (2015)
  • http://www.jneurosci.org/content/35/21/8333.short

There are a substantial number of studies showing that the orbitofrontal cortex links events to reward values, whereas the hippocampus links events to the context in which they occur. Here we asked how the orbitofrontal cortex contributes to memory where context determines the reward values associated with events. After rats learned object–reward associations that differed depending on the spatial context in which the objects were presented, neuronal ensembles in orbitofrontal cortex represented distinct value-based schemas, each composed of a systematic organization of the representations of objects in the contexts and positions where they were associated with reward or nonreward. Orbitofrontal ensembles also represent the different spatial contexts that define the mappings of stimuli to actions that lead to reward or nonreward. These findings, combined with observations on complementary memory representation within the hippocampus, suggest mechanisms through which prefrontal cortex and the hippocampus interact in support of context-guided memory.

This talk is part of the Computational Neuroscience series.

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