Chromatin-mediated regulation of gene expression in mouse ES cells
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If you have a question about this talk, please contact Florian Markowetz.
Stem cells have the intrinsic ability to activate a number of
alternative gene expression programs in response to inductive signals
while maintaining stable expression of the stem cell-specific program
to ensure self-renewal. The role of transcription factors in
maintaining this balance is well recognised and mounting evidence
points to an important role of epigenetic regulation, consistent with
frequent mutation of epigenetic regulators in developmental disorders
and cancer. Compared to somatic cell types, embryonic stem (ES) cells
have an ‘open’ chromatin structure with a primed configuration at
genes encoding key regulators of all three germ layers. This flexible
chromatin state reflects the wide developmental potential of ES cells
and is recreated when differentiated cell types are reprogrammed to
pluripotency. Upon differentiation of ES cells, epigenetic marks are
subject to wide-spread redistribution resulting in genome
compartmentalisation. We study chromatin-mediated control of gene
expression in ES cells and during differentiation in order to
understand the regulation of mammalian development.
This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.
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Monday 03 October 2011, 16:00-17:00