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Computational Neuroscience Journal Club

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If you have a question about this talk, please contact Daniel McNamee.

Rodrigo Echeveste will cover:

  • Diversity in neural firing dynamics supports both rigid and learned hippocampal sequences
  • Andres Grosmark, György Buzsáki
  • Science (March 2016)
  • Link to paper

ABSTRACT : Cell assembly sequences during learning are “replayed” during hippocampal ripples and contribute to the consolidation of episodic memories. However, neuronal sequences may also reflect preexisting dynamics. We report that sequences of place-cell firing in a novel environment are formed from a combination of the contributions of a rigid, predominantly fast-firing subset of pyramidal neurons with low spatial specificity and limited change across sleep-experience-sleep and a slow-firing plastic subset. Slow-firing cells, rather than fast-firing cells, gained high place specificity during exploration, elevated their association with ripples, and showed increased bursting and temporal coactivation during postexperience sleep. Thus, slow- and fast-firing neurons, although forming a continuous distribution, have different coding and plastic properties.

This talk is part of the Computational Neuroscience series.

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