"Understanding the role of secondary outcomes in multivariate meta-analysis"

Add to your list(s) Download to your calendar using vCal

• Professor John Copas, University of Warwick
• Tuesday 09 February 2016, 14:30-15:30
• Large Seminar Room, 1st Floor, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge.

If you have a question about this talk, please contact Alison Quenault.

Abstract: Meta-analysis is usually univariate, estimating the mean treatment effect for the outcome of primary interest. However, many clinical studies will also measure secondary outcomes. Multivariate meta-analysis allows us to take these secondary outcomes into account, and also allows us to include studies where the primary outcome is missing. How much is gained by taking these secondary outcomes into account? In most statistical problems we get more accurate estimates if we include other data which are correlated with the main object of interest. But in meta-analysis, the contribution of any particular study’s secondary outcomes depends not only on the between-outcome correlations but, crucially, on how typical the study’s research design is of the meta-analysis as a whole. A graphical interpretation will be suggested, and illustrated using a recent meta-analysis of ten anti-hypertension clinical trials.

This talk is part of the MRC Biostatistics Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• BHRU Annual Lecture 2015
• BHRU Annual Lecture 2016
• Biology
• Cambridge Centre for Data-Driven Discovery (C2D3)
• Cambridge Immunology
• Cambridge talks
• Cardiovascular Epidemiology Unit Special Seminars
• Chris Davis' list
• Department of Public Health and Primary Care
• Graduate-Seminars
• Interested Talks
• Large Seminar Room, 1st Floor, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge
• Life Sciences
• Life Sciences
• ME Seminar
• MRC Biostatistics Unit Seminars
• Primary Care
• PublicHealth@Cambridge
• Trust & Technology Initiative - interesting events
• bld31
• my_list
• ndk22's list
• ob366-ai4er
• other talks
• primary care
• rp587

Note that ex-directory lists are not shown.