Using metagenomics to identify emerging viral pathogens, and RNA silencing to combat them

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• Luke Braidwood, Baulcombe Lab
• Friday 12 December 2014, 11:00-11:30
• Department of Plant Sciences, Large Lecture Theatre.

If you have a question about this talk, please contact Megan Cooper.

Maize lethal necrosis (MLN) is a synergistic viral maize disease. It has recently spread to South-East Asia and East Africa, where it represents a serious threat to a major food crop. The infection is produced by the interaction of Maize chlorotic mottle virus (MCMV) and maize-infecting Potyviridae viruses. Both MCMV and the Potyviridae can use a variety of insect vectors to spread between hosts. I am using next generation sequencing to survey the genomic diversity of viruses in East African maize. This sequence data will be used to identify conserved regions of the viral genomes which produce MLN , and artificial mircroRNAs will be designed to target these regions and inserted into maize. The ultimate aim is to produce maize varieties with increased resistance to MLN , thereby improving food security in East Africa. In addition I am using artificial innoculation and molecular methods to investigate the methods of pathogenesis and synergy between the viruses.

1st year graduate seminar

This talk is part of the Plant Sciences Departmental Seminars series.

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