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Near-Field Electrospinning of Biomimetic Niche

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If you have a question about this talk, please contact Ms Helen Gardner.

Natural extracellular matrix (ECM) consists of well-defined architecture and spatial patterns formed by fibril features ranging from nanometre to micrometre scale. Constructing biointerfaces which recapitulate the essential topological cues of an ECM can help elucidate the key mechanotransduction pathways. It can also reveal the role of micro-environments in controlling primary cell processes, including differentiation, migration and proliferation. The proposed work focuses on developing topologically defined biomaterial constructs for controlled mechano-biology research. I will show you our recent development in this area, which involves a bio-mechanically regulated cancer migration assay, as well as guided assembly of vascular network. It is envisaged that NFES may provide a facile and versatile bio-fabrication platform, offering the possibility to personalised therapeutic implants for tissue regeneration and drug screening.

This talk is part of the Engineering - Mechanics and Materials Seminar Series series.

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