University of Cambridge > Talks.cam > MRC Biostatistics Unit Seminars > Modelling heterogeneity in gene expression using the matrix-variate normal distribution

  Browse A-Z

Log in

Cambridge users (raven)details Other usersdetails No account?details

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

Modelling heterogeneity in gene expression using the matrix-variate normal distribution

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Dr Jack Bowden.

In this talk, we consider the problem of modeling gene expression levels when measurements are made on multiple samples taken from the same individual. The primary biological goal is to assess the heterogeneity of the expression levels within each individual and, subsequently, between all individuals. This type of data may arise in cancer studies with multiple subsamples taken from each tumor. From a statistical perspective our primary concern is the accurate estimation of the association structure of the correlated samples and of the genes. For this purpose, we apply the matrix-variate normal distribution, which allows us to estimate separately the covariance/correlation matrix among the correlated subsamples and the genes. We derive covariance estimators and discuss their properties, and we develop test statistics for the sphericity and identity hypothesis testing of the covariance matrices. Finally, we illustrate the above using a real data set from a cancer study. This is a joint work with John Marioni and Simon Tavaré.

This talk is part of the MRC Biostatistics Unit Seminars series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Cambridge University United Nations Association (CUUNA) Clare Hall Lecture: The evolution of Abcam plc - 30 April 2013 ee287's list

Other talks

Retinal mechanisms of non-image-forming vision Mandatory Madness: Colonial Psychiatry and British Mandate Palestine, 1920-48 Phylogenetic hypothesis of the Oleeae tribe (Oleaceae)
 Diversification and molecular evolution patterns in plastid and nuclear ribosomal DNA The microenvironment in the myeloid malignancies Prof Kate Jones (UCL): Biodiversity & Conservation Beyond crazy: Rationality, irrationality, and conspiracy theory Singularities of Hermitian-Yang-Mills connections and the Harder-Narasimhan-Seshadri filtration The ‘Easy’ and ‘Hard’ Problems of Consciousness Amino acid sensing: the elF2a signalling in the control of biological functions Are hospital admissions for people with palliative care needs avoidable and unwanted? An SU(3) variant of instanton homology for webs Large Scale Ubiquitous Data Sources for Crime Prediction
 

© 2006-2024 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity