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Using bespoke fluorescence microscopy to study the soft matter of living cells at the single molecule level

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If you have a question about this talk, please contact Tracy Inman.

The use of bespoke imaging tools and analysis can offer significant insight into the living counterpart of soft condensed matter. The soft matter of biological systems consists of molecular building blocks, a staple of which is protein. Protein molecules, so small that 1 billion would fit on the full-stop at the end of this sentence, carry out most of the vital activities in living cells. Many of these processes require the assembly of multiple proteins into remarkable biological machines. Obtaining the blueprints for the architecture of these machines is essential for understanding the workings of the cell. Here, I will discuss recent biological physics experiments on functional single-celled organisms in which one can apply bespoke fluorescence microscopy imaging and analysis to monitor the number and dynamics of several different proteins at the nanometre length scale to a precision of single molecules. 1

1. Reyes-Lamothe R, Sherratt DJ, Leake MC. Stoichiometry and architecture of active DNA replication machinery in Escherichia coli. Science. 2010, 328, 498-501.

This talk is part of the BSS Formal Seminars series.

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