Mapping DNA replication stress in cancer cells and parasites with long-read sequencing and AI

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• Dr Michael Boemo
• Thursday 22 February 2024, 16:00-17:00
• Biffen Lecture Theatre, Department of Genetics, Downing Site.

If you have a question about this talk, please contact Samantha Noel.

Every time a cell divides, it must replicate its genome exactly once, which it achieves through the parallel action of replication forks. The frequent slowing or stalling of replication forks, termed “replication stress”, is common in both cancer cells and parasites. Replication stress is therefore a common therapeutic target for anti-malarial and cancer chemotherapies, but we have a relatively poor understanding of where, when, why, and how often replication forks stall under these therapies. I will discuss our recent progress towards answering these questions, whereby we are using long-read nanopore DNA sequencing together with AI to measure the movement and stress of thousands of replication forks across the genomes of human cancer cells and malaria parasites.

This talk is part of the Computational and Systems Biology Seminar Series 2023 - 24 series.

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