Toward Better Bone Regeneration: Innovation in Metallic and Ceramic Scaffolds

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• Prof. Donghui Zhu,
• Friday 29 September 2023, 14:00-15:00
• Oatley Seminar Room, Department of Engineering.

If you have a question about this talk, please contact Hilde Hambro.

Critical-sized bone defects remain a significant challenge in clinical settings for the purpose of regeneration. Although bone grafts are a viable treatment option, their clinical application is hindered by surgical risks and the morbidity associated with autologous grafts, as well as limitations in sourcing and the risks of alloimmunity with allogeneic grafts. Various types of scaffolding materials, including ceramics, polymers, metals, and composite materials, have been extensively investigated. While ceramic or polymer scaffolds may be suitable for low-stress loading bone defect sites, metal scaffolds provide the necessary mechanical support and stability for high load-bearing scenarios, such as long bone defects. This seminar will focus on recent advancements in the utilization of biodegradable metals and bioactive bone cements as bioresorbable scaffolds to enhance bone regeneration. Taking advantages of additive manufacturing techniques, these scaffolds offer significant potential in the treatment of bone defects, thanks to their porous, customizable architecture, and functionalization capabilities. Moreover, these materials gradually corrode while maintaining their mechanical integrity during the critical tissue healing phase, ultimately dissolving completely once they have fulfilled their purpose.

Biography: Donghui Zhu is a distinguished scholar and SUNY Empire Innovation Professor in the Department of Biomedical Engineering, Institute for Engineering-Driven Medicine, Center of Healthy Aging, and Neuroscience Program at SUNY -Stony Brook University. He completed his Ph.D. in Bioengineering from the University of Missouri-Columbia in 2006 and then pursued postdoctoral training at the University of Rochester. Since joining academia in 2010 as a tenure-track faculty member, Dr. Zhu has been committed to the field of biomaterials and tissue engineering. Dr. Zhu’s research endeavors span a wide range of medical applications, including medical implants and devices, regenerative medicine, and therapies for cardiovascular diseases, musculoskeletal disorders, aging, and dementia. His groundbreaking research has garnered over $10 million in total extramural research funding and produced more than 100 peer-reviewed publications, establishing him as a leading figure in his field. He is an elected Fellow of the American Heart Association (AHA) and the American Institute for Medical and Biological Engineering (AIMBE). Moreover, Dr. Zhu serves as an editor-in-chief for two prestigious scientific journals, “Smart Material in Medicine” and “Engineered Regeneration,” in addition to his position on the editorial board of numerous scientific journals. He is a member of several federal grant review panels, including NIH , NSF, FDA , and NASA . Through his exceptional research and leadership, Dr. Zhu has made seminal contributions to the field of biomedical engineering and continues to advance the frontier of regenerative medicine.

This talk is part of the Engineering - Mechanics and Materials Seminar Series series.

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