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University of Cambridge > Talks.cam > Computational Neuroscience > Computational Neuroscience Journal Club
Computational Neuroscience Journal ClubAdd to your list(s) Download to your calendar using vCal
If you have a question about this talk, please contact Rodrigo Echeveste. Marcelo Mattar will be presenting: • Big-Loop Recurrence within the Hippocampal System Supports Integration of Information across Episodes • Raphael Koster et al. • Neuron 2018 • https://doi.org/10.1016/j.neuron.2018.08.009 Abstract: Recent evidence challenges the widely held view that the hippocampus is specialized for episodic memory, by demonstrating that it also underpins the integration of information across experiences. Contemporary computational theories propose that these two contrasting functions can be accomplished by big-loop recurrence, whereby the output of the system is recirculated back into the hippocampus. We use ultra-high-resolution fMRI to provide support for this hypothesis, by showing that retrieved information is presented as a new input on the superficial entorhinal cortex—driven by functional connectivity between the deep and superficial entorhinal layers. Further, the magnitude of this laminar connectivity correlated with inferential performance, demonstrating its importance for behavior. Our findings offer a novel perspective on information processing within the hippocampus and support a unifying framework in which the hippocampus captures higher-order structure across experiences, by creating a dynamic memory space from separate episodic codes for individual experiences. This talk is part of the Computational Neuroscience series. This talk is included in these lists:
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Marcelo Mattar (CBL)
Tuesday 27 November 2018, 16:00-17:00