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Dissecting translation efficiency through lab evolution, genome engineering and inspection of the cancerous genome

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Translation efficiency is determined, in part, by the supply-to-demand relationships between the tRNA and mRNA pools in cells. To better understand translation we perturb the system through tRNA gene manipulation and recoding open reading frames. We then follow such perturbed and genome engineered bacteria and yeast cells through lab evolution and comparative genomics and reveal how evolution acts to adapt supply to demand. I will also discuss our study of the cancerous tRNA and mRNA pools. I will show how cancers sustain high translation efficiency of genes that carry out cell autonomous, hence oncogenic, functionalities.

Hosted by Duncan Odom

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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