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Immunology in Pathology
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A seminar series organised from the Division of Immunology in the Department of Pathology, supported in part by the British Society for Immunology (BSI) through the Cambridge Regional Group. The seminars are in the Pathology Building on the Downing site (fronting on Tennis Court Road) from 12:30-1:30 on Wednesdays during term time. If you have a question about this list, please contact: Phil Brereton; Christine Sexton. If you have a question about a specific talk, click on that talk to find its organiser. 0 upcoming talks and 335 talks in the archive. AMPK phosphorylation of FNIP1 dictates the kinetics of lysosome and mitochondrial biogenesis
Title to be confirmed
Unexpected roles for ubiquitin in immunity.
Therapeutic targeting of recurrently mutated driver oncogenes using TCR gene therapy
Can viral infections exacerbate the onset of Alzheimer’s Disease?
Regulation of innate immune activation during viral infections
T cells in the brain
Preventing and reversing immunopathology: respective roles of regulatory CD4 T cells and regulatory plasma cells
Mazes models and maths - discovering how chemotactic cells decide where to go, and how reverse chemotaxis can work
The discriminatory power of the T cell antigen receptor
Control of cGAS-STING signalling in cancer
Investigating thymic Treg selection and death by a transcriptional timer and single cell methods.Host: Rahul Roychoudhuri, rr257@cam.ac.uk
Uncertainties around SARS-CoV-2 infection and immunity.Host: Nick Holmes, nh106@cam.ac.uk
Principles of squamocolumnar transition zone homeostasis: metaplasia, infections, and cancers.Host: Margherita Turco, myt25@cam.ac.uk
The Marginal Zone B cell - T follicular helper cell connection.Host: Klaus Okkenhaug, ko256@cam.ac.uk
Isolation and analysis of Immune niches along the human intestine.Host: Klaus Okkenhaug (ko256@cam.ac.uk), tea and coffee available at 12.15
Protection against pathogen colonisation and transmission by the microbiota.Host: Klaus Okkenhaug (ko256@cam.ac.uk), tea and coffee available at 12.15
Oxygen-dependent control of T-cell mediated immunity.Host: Nick Holmes, (nh106@cam.ac.uk), tea and coffee available at 12.15
Mechanisms of germinal centre dependent antibody dysregulation in early life.Host: Naomi McGovern, nm390@cam.ac.uk; Tea and coffee will be available at 12.15
Candida recognition and manipulation of NK cells.Host: Dr Francesco Colucci (fc287@medschl.cam.ac.uk)
Adaptive control of RIPK1 dependent cell death signalling in T-cells.Tea and coffee will be available at 12.15
Molecular approaches for studying antigen processing topology and T-cell activation kinetics.Host: Louise Boyle (lhb22@cam.ac.uk), tea and coffee available at 12.15pm
Epitope target discovery: what can we see when we think outside the box.Host: Louise Boyle (lhb22@cam.ac.uk), tea and coffee available at 12.15pm
Integrative NMR, Molecular Modeling, and Functional studies of immune recognition complexesHost: Louise Boyle (lhb22@cam.ac.uk), tea and coffee available at 12.15pm
Meticulous and Multifaceted: How herpes viruses fine tune the innate immune response.Host: Brian Ferguson (bf234@cam.ac.uk)
Immune cell recognition on a nanoscale.Host: Louise Boyle (lhb22@cam.ac.uk)
HLA-E RevisitedHost: John Trowsdale (Jt233@cam.ac.uk)
Understanding hepatic macrophage heterogeneity and function in NAFLDHost: Naomi McGovern (nm390@cam.ac.uk)
CD8 T cell surveillance of lymphoid and non-lymphoid tissues.Host: Klaus Okkenhaug (ko256@cam.ac.uk)
How do macrophages respond to danger?Host: Naomi McGovern, nm390@cam.ac.uk; Tea and coffee will be available at 12.15
Reining in T follicular helper cells in humoral immunity and T cell lymphomaHosted by: Klaus Okkenhaug. There will be tea and coffee available at 12.15.
Integrating T cell SignalsNote unusual time, (Tuesday 1230) (12.15 Refreshments available)
From SNPs to biology in autoimmune diseaseHost: James Traherne (jat51@cam.ac.uk)
Intracellular trafficking for immunityHost: Brian Ferguson (bf234@cam.ac.uk)
Uterine immunity one cell at a timeHost: Dr Bidesh Mahata (bm11@sanger.ac.uk)
‘In vivo tracking of immune cell migration: towards a better understanding of tumour infiltrating lymphocytes’Host: Dr Bidesh Mahata (bm11@sanger.ac.uk)
Adaptive immunity in wild songbirdsHost: Professor Jim Kaufman (jfk31@cam.ac.uk)
Antigen receptor repertoires and specificities at single-cell resolutionHost: Dr Bidesh Mahata (bm11@sanger.ac.uk)
Regulators of chicken B cell development – basic research and applicationHost: Professor Jim Kaufman (jfk31@cam.ac.uk)
Fish 'n' HIFs: Hypoxia signalling in zebrafish models of infection and inflammationHost: Dr Naomi McGovern (nm390@cam.ac.uk)
Immune regulatory functions of group 2 innate lymphoid cellsHost: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Niche dependencies for normal and malignant B1 cellsHost: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Organoid Systems to Study the Maternal-Fetal Interface of Human PregnancyHost: Dr Naomi McGovern (nm390@cam.ac.uk)
Beyond the cancer cell: Exploring the tumour stroma as immune modulatorsHost: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Engineering the genetic events of lymphomagenesis in normal human germinal centre B-cellsHost: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
CANCELLEDCanceled
Darwin's digital moth: predicting the existence of new components of immune systems by evaluating convergent patterns of nucleotide motif usage in viruses and their hostsHost: Dr Brian Ferguson (bf234@cam.ac.uk)
Mitochondria as inflammatory killersHost: Dr Brian Ferguson (bf234@cam.ac.uk)
T cell intrinsic role of Arginase 2 in modulating anti-tumor immunityHost: Professor Jim Kaufman (jfk31@cam.ac.uk)
Host MHC and genomic diversity retards experimental evolution of viral virulenceHost: Professor Jim Kaufman (jfk31@cam.ac.uk)
Understanding human innate immune memoryHost: Dr Naomi McGovern (nm390@cam.ac.uk)
Monocyte kinetics and functions in health and diseaseHost: Dr Naomi McGovern (nm390@cam.ac.uk)
New insights into how Butyrophilin(-like) proteins shape gammadelta T cell repertoiresHost: Professor Jim Kaufman (jfk31@cam.ac.uk)
Tracking hematopoietic clonal life histories in the rhesus macaque modelHost: Dr Andrew Sharkey (as168@cam.ac.uk)
Global outbreaks: interferons as first respondersHost: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Challenges in human respiratory viral infectionHost: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Adaptive immunesurveillance by human γδ T cellsHost: Dr David Rhodes (dar32@cam.ac.uk)
Regulation of resistance and tolerance at the intestinal barrierHost: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Red Queen drives selection on MHC genesHost: Professor Jim Kaufman(jfk31@cam.ac.uk)
A novel aspect of Macrophage biology: learning from the great opportunist HIV-1Host: Dr Naomi McGovern (nm390@cam.ac.uk)
Novel kinases controlling T cell development, trafficking and immune responsesHost: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
Type I IFN induces CXCL13-driven B cell recruitment to the lung to enable tertiary GC formationHost: Dr Brian Ferguson (bf234@cam.ac.uk)
Characterizing Immunogenetic Mechanisms through HIV Disease AnalysisHost: Dr James Traherne (jat51@cam.ac.uk)
Metabolic regulation of T cell traffickingHost: Professor Klaus Okkenhaug (ko256@cam.ac.uk)
NK cells: in and out of the circulationHost: Dr Andrew Sharkey (as168@cam.ac.uk)
'Gene regulation in the innate and adaptive immune systems'Host: Dr Nick Holmes (nh106@cam.ac.uk)
A sex-linked supergene controls sperm morphology and swimming speed in a songbirdHost: Professor Jim Kaufman (jfk31@cam.ac.uk)
How T-cells cause autoimmune disease and hold the key to curing cancerHost: Professor Jim Kaufman (jfk31@cam.ac.uk)
Phenotypic model explains adaptation of T cell responses to antigen by TCR downregulationHost: Dr Nick Holmes (nh106@cam.ac.uk)
Diversity of the human response to malariaHost: Dr Maja Wållberg (mw394@cam.ac.uk)
Metabolic adaptation as a disease tolerance mechanism against infectionHost: Dr Brian Ferguson (bf234@cam.ac.uk)
Immunity in early life: the case of gammadelta T cellsHost: Dr David Rhodes (dar32@cam.ac.uk)
Stromal microenvironments and the control T-cell development and selectionHost: Dr Nick Holmes (nh106@cam.ac.uk)
Glucose inhibits Dendritic cell-induced CD8 T cell responsesHost: Dr Maja Wallberg (mw394@cam.ac.uk)
Genetic analyses of ANCA-associated vasculitis inform diagnostic and therapeutic strategies.Host: Dr James Traherne (jat51@cam.ac.uk)
Dendritic cells and antigen export into the cytosol for cross-presentationHost: Dr Louise Boyle (lhb22@cam.ac.uk
Exploring the functions of monocyte subsetsHost: Dr Naomi McGovern (nm390@cam.ac.uk)
Death receptors and ubiquitin in cell death, inflammation and immunityHost: Dr Brian Ferguson (bf234@cam.ac.uk)
Immunorecognition and disease therapyHost: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr David Tscharke: Vaccinia virus presents: A proteome-wide view of antigen presentation during virus infectionHost: Dr Brian Ferguson (bf234@cam.ac.uk)
Prof Robyn Slattery: The Songlines between Scientific and Social Silos: A nomadic approach to Immunology teaching, learning and researchHost: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Maike de la Roche: Hedgehog Signalling in T cellsHost: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr Becca Asquith: KIRs, CD8 T cell dynamics and control of chronic viral infection
Dr Sarah Teichmann: Understanding Cellular HeterogeneityHost: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Tony Jackson: Protein neighbours and proximity proteomicsHost: Prof Jim Kaufman (jfk31@cam.ac.uk)
Professor Alain Vanderplasschen: Conserved fever pathways across vertebrates: a herpesvirus delays fish behavioural fever through expression of a decoy Tnfα receptorHost: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr David Komander: Studying non-existent ubiquitin chainsHost: Dr Brian Ferguson (bf234@cam.ac.uk)
Prof Jan Rehwinkel: Nucleic Acid Sensing by Innate Immune ReceptorsHost: Dr Brian Ferguson (bf234@cam.ac.uk)
Dr Amir Horowitz: Harnessing NK cell functions for treatments against viruses and cancersHost: Dr Andrew Starkey
Prof Serge Muyldermans: Nanobodies, a versatile tool for multiple applicationsHost: Lisa Kent (lsk29@cam.ac.uk)
Prof Benedikt Kaufer: Herpesvirus latency: From neuronal models to integration into host telomeresHost: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr Serge Mostowy: New roles for the cytoskeleton in cell-autonomous immunityHost: Dr Francesco Colucci (fc287@medschl.cam.ac.uk)
Prof Steve Renshaw: Will zebrafish help lead a revolution in inflammation biology?Host: Dr Milka Sarris (ms543@cam.ac.uk)
Prof Peter Parham: Resurrecting an Intermediate in the Evolution of Human HLA-C specific NK Cell ReceptorsHost: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr Neil McCarthy: Human Vδ2+ T-cells in Intestinal InflammationHost: Dr David Rhodes (dar32@cam.ac.uk)
Dr Leonie Unterholzner: Sensing intracellular DNA as "stranger" and "danger" signalHost: Ben Trigg (bjt40@cam.ac.uk)
Dr Frank Waldron-Lynch: Immune Cell Responses in Participants with Type 1 Diabetes after doses of Interleukin-2 in adaptive-response clinical trialsHost: Dr Louise Boyle (lhb22@cam.ac.uk)
Prof Anthony Purcell: New insights into antigen presentation using quantitative immunopeptidomicsHost: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr Oliver Bannard: Germinal centres; regulation by position and programHost: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Peter van Endert: Intracellular trafficking events regulating MHC class I antigen cross-presentation by dendritic cellsHost: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr David Bending: A novel tool to visualize and manipulate the dynamics of T cell regulation in vivoHost: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Megan MacLeod: Regulation of CD4 T cell retention and function at inflamed sitesHost: Dr Maja Wallberg (mw394@cam.ac.uk)
Professor Geoffrey L Smith: Modulation of CD8+ T cell and NK cell memory by vaccinia virusHost: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Pavel Tolar: The biomechanics of B cell activationHost: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Peter Bull: Exploring host selection pressures on malaria parasite populations during human infectionHost: Dr Nick Holmes (nh106@cam.ac.uk)
Dr Anja Schmidt-Christensen: Dissecting inflammation in diabetesHost: Dr Maja Wallberg (mw394@cam.ac.uk)
Dr Peter Bull:Host: Dr Nick Holmes (nh106@cam.ac.uk)
Prof Wilf Jefferies: Weft, Warp & Weave: The intricate tapestry of antigen processing pathways controlling T lymphocyte functionHost: Prof John Trowsdale (jt233@cam.ac.uk)
Prof Thomas Herrmann: Control of Vgamma9Vdelta T cell activation by butyrophilin 3 and their possible coevolutionHost: Dr David Rhodes (dar32@cam.ac.uk)
Dr Duncan Howie: T cell metabolism and immune toleranceHost: Dr Maja Wallberg (mw394@cam.ac.uk)
Dr Jodie Goodridge: Natural Killer PotentialHost: Prof John Trowsdale (jt233@cam.ac.uk)
Dr Francois Legoux: CD4+ T cell tolerance to self-antigensHost: Dr Maja Wallberg (mw394@cam.ac.uk)
Prof Paul Bowness: Type 17 immune responses in Ankylosing SpondylitisHost: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr Michael Weekes: New insights into human cytomegalovirus immune evasion from quantitative multiplexed proteomicsHost: Dr Louise Boyle (lhb22@cam.ac.uk)
Prof Connie Trimble: HPV therapeutic vaccines – where are we now and where are we going?Host: Prof Margaret Stanley (mas1001@cam.ac.uk)
Dr Pia Kvistborg: What T cells see on human cancerHost: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr Antonio Rothfuchs: Dendritic cell migration and T-cell priming to Bacille Calmette-GuérinHost: Dr Brian Ferguson (bf234@cam.ac.uk)
Dr Jatin Vyas: Dectin-1 and innate immunity against fungal pathogensHost: Dr Katerina Artavanis-Tsakonas (ka447@cam.ac.uk)
Dr Piero Mastroeni: Immunity and vaccination to invasive Salmonella infections: How can we integrate the lessons from animal models and man?Host: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr Jane Goodall: How can I modify dendritic cell biology? A lesson from TSLPHost: Dr Brian Ferguson (bf234@cam.ac.uk)
Prof Philip Goulder: Non-progressing paediatric HIV infectionHost: Dr Louise Boyle (lhb22@cam.ac.uk)
Prof Lutz Walter: Immunogenetics of the rhesus macaque SIV infection modelHost: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr Marion Espeli: New mechanisms of regulation of germinal centre B cells and plasma cellsHost: Dr Maja Wallberg (mw394@cam.ac.uk)
Dr Ian Humphreys: Immune Regulation during Cytomegalovirus Infection: Walking a Fine LineHost: Dr Louise Boyle (lhb22@cam.ac.uk)
Prof Jim Kaufman: A gut feeling about MHC class II moleculesHost: Dr Brian Ferguson (bf234@cam.ac.uk)
Dr Nicola Ternette: Definition of the origin and nature of HLA class I-associated peptide presentation from HIV-1 using mass spectrometry.Host: Prof Jim Kaufman (jfk31@cam.ac.uk)
Dr Klaus Okkenhaug: PI3K in infection, immunity and cancer.Host: Dr Brian Ferguson (bf234@cam.ac.uk)
Dr Eoin McKinney: Sometimes better off sick and tired - T cell exhaustion and outcome in autoimmunity and infection.Host: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr Emmanuel Donnadieu: Decoding T cell responses to cancer with dynamic imagingHost: Prof John Trowsdale (jt233@cam.ac.uk)
Dr Edd James: Immune Dysfunction: the role of polymorphic ERAP1 in disease.Host: Dr Louise Boyle (lhb22@cam.ac.uk)
Dr Yongliang Zhang: MKP5, a novel regulator of IRF3-type I IFNs, critically modulates host-pathogen interaction in influenza and other RNA virus infections.Host: Prof John Trowsdale (jt233@cam.ac.uk)
Dr Naomi McGovern: Human dendritic cells – from adult to fetus.Host: Dr Francesco Colucci (fc287@medschl.cam.ac.uk)
Generators of diversity and the host-pathogen interfaceDr Nina Papavasiliou, The Rockefeller Institute, New York
Trophoblast-microbiota interaction: a new paradigm on immune regulation during pregnancyHost: Francesco Colucci (fc287@medschl.cam.ac.uk)
Navigating through tissue mazes: how leukocytes find their way to sites of infection’Host: Brian Ferguson (bf234@cam.ac.uk)
MHC class I : From viral evasion to cellular quality control?Host: John Trowsdale (jt233@cam.ac.uk)
A novel gene essential for the generation of reactive oxygen species and host defenceHost: Nick Holmes (nh106@cam.ac.uk)
Decoding immune responses to cancer and infection using intravital imagingHost: Milka Sarris (ms543@cam.ac.uk)
Tuberculous Granuloma Formation and FunctionHost: Brian Ferguson (bf234@cam.ac.uk)
Studying CD4+ T cell interactions with dendritic cells in vivoHost: Maja Wallberg (mw394@cam.ac.uk)
New Pathophysiological Roles of Atypical Chemokine ReceptorsHost: Dr Milka Sarris (ms543@cam.ac.uk)
Intracellular DNA recognition by the innate immune systemHost: Dr Brian Ferguson (bf234@cam.ac.uk)
How protein plasticity influences MHC class I peptide selection: insights into mechanismHost: Professor Jim Kaufman (jfk31@cam.ac.uk)
Group 2 Innate Lymphoid Cells regulate the innate and adaptive immune response to inhaled allergensHost: Dr Brian Ferguson (bf234@cam.ac.uk)
Bacterial autophagy and the cytoskeleton in host defenceHost: Dr Milka Sarris (ms543@cam.ac.uk)
Human Cytomegalovirus the paradox of immune evasion and controlHost: Professor John Trowsdale (jt233@cam.ac.uk)
Regulation of T cell homeostasis by tyrosine phosphatase PTPN22Host: Dr Nick Holmes (nh106@cam.ac.uk)
Responses of mesenchymal stromal cells to hypoxiaHost: Jim Kaufman (jfk31@cam.ac.uk)
The impact of metabolism on NK cell immune functionsHost: John Trowsdale (jt233@cam.ac.uk)
Innate immune cell memoryHost: Brian Ferguson (bf234@cam.ac.uk)
Autophagy in host-pathogen interactionsHost: John Trowsdale (jt233@cam.ac.uk)
The IL-6 cytokine family and CD4+ T cell response during acute and chronic viral infectionsHost: Chris Rudd (cer51@cam.ac.uk)
Myeloid lineage switch in pro-B cells generates novel M phi subsets during homeostasis & inflammationHost: Paola Zaccone (pz206@cam.ac.uk)
CANCELLEDHost: Brian Ferguson (bf234@cam.ac.uk)
Positive and Negative Selection in Avian B Cell DevelopmentHost: Jim Kaufman (jfk31@cam.ac.uk)
An inverse correlation of cell surface expression level and peptide binding repertoire for MHC class I molecules is associated with disease resistance in chickens and humansHost: Brian Ferguson (bf234@cam.ac.uk)
Regulation of virally-induced lung inflammation by interferonsHost: Brian Ferguson (bf234@cam.ac.uk)
Sensing and signalling in innate immunity: Role of PYHIN proteinsHost: Brian Ferguson (bf234@cam.ac.uk)
C-type lectins in homeostasis and immunityHost: Paola Zaccone (pz206@cam.ac.uk)
Killer T Cells: staying on targetHost: Ashley Moffett (am485@cam.ac.uk)
Using genomics to refine diagnosis and prognosis in ANCA-associated vasculitisHost: Professor John Trowsdale (jt233@cam.ac.uk)
Ex-FoxP3 Regulatory T cells uniquely populate the inflamed site in childhood arthritisHost: Nick Holmes (nh106@cam.ac.uk)
Pattern Recognition Receptors and Infection: Following the SpeckHost: Brian Ferguson (bf234@cam.ac.uk)
Targeting Immune Checkpoints in Cancer: New Mechanistic InsightsHost: Chris Rudd, cer51@cam.ac.uk
Inhibition of HIV-1-cofactor interactions triggers innate sensors and interferon secretionHost: Brian Ferguson, bf234@cam.ac.uk
Exploring the mechanisms of immunity operating against a protist parasite of the gutHost: Ben Trigg, bjt40@cam.ac.uk
Trafficking of MHC class I molecules is influenced by so many things - lessons from a new peptide-independent mutantHost: Dr Louise Boyle, lhb22@cam.ac.uk
How hepatitis B virus exploits the immune environment in the liverHost: Ashley Moffett, am485@cam.ac.uk
The unicity of diversity: cross-allele T-cell responses against viruses and tumors among different HLA-A supertypes and the structural basesHost: Jim Kaufman, jfk31@cam.ac.uk
Immune-mediated sperm selectionHost: Jim Kaufman, jfk31@cam.ac.uk
Apoptosis, Necrosis, Atherosclerosis and IL-1Host: John Trowsdale, jt233@cam.ac.uk
The double life of killer cells: NK in reproduction and cancerHost: John Trowsdale, jt233@cam.ac.uk
Host-pathogen interactions in the chicken - from molecules to mappingHost: Jim Kaufman (jfk31@cam.ac.uk)
Migration in Development and Immune Function: the Role of alpha4 integrin (CD49d, VLA-4)Host: Dr Nick Holmes (nh106@cam.ac.uk)
New insight into the mechanism controlling peptide selection by MHC class IHost: John Trowsdale (jt233@cam.ac.uk)
Transancestral Fine mapping of Susceptibility Loci in SLEHost: John Trowsdale (jt233@cam.ac.uk)
Reproduction, infection and KIR evolution: a modelling approachHost: Professor Ashley Moffett (am485@cam.ac.uk)
Shooting the messenger - Unique cytotoxic strategy in recently activated CD8 T cellsHost: Professor Chris Rudd (cer51@cam.ac.uk)
Studies on pathogen-macrophage interactions: a possible role for a secreted Mycobacterium tuberculosis lectinHost: Dr Brian Ferguson (bf234@cam.ac.uk)
Influenza Adrift: Rethinking Influenza A Virus EvolutionHost: Dr Adrian Kelly (apk23@cam.ac.uk)
Viral inhibition of DNA-PK dependent DNA sensingHost: Professor Jim Kaufman (jfk31@cam.ac.uk)
A View to a Kill - Natural killer cell recognition of classical, non classical and virus-encoded MHC-like moleculesHost: Professor Ashley Moffett (am485@cam.ac.uk)
Conservation of Binding by Leukocyte Receptor Complex family members to Class I Antigen Presenting Molecules: Why does KIR3DL1 bind Mouse H-2Db?Host: Professor Ashley Moffett (am485@cam.ac.uk)
Ecology, evolution and ecosystem consequences of a novel infectious cancer: Tasmanian devil facial tumour diseaseHost: Professor Jim Kaufman (jfk31@cam.ac.uk)
Influence of HLA-C expression level on HIV controlHost: Ashley Moffett (am485@cam.ac.uk)
Macrophage heterogeneity and renewal during inflammationHost: John Trowsdale (jt233@cam.ac.uk)
Mothers' compromise. How NK cells regulate placentation.Host: Jim Kaufman (jfk31@cam.ac.uk)
Immunomodulation of Type 1 Diabetes by Schistosome mansoni productsHost: Jim Kaufman (jfk31@cam.ac.uk)
Recombinant HPA-1a antibody therapy for treatment of fetomaternal alloimmune thrombocytopeniaHost: Mike Clark (mrc7@cam.ac.uk)
Burning bridges. Transgenic approaches to eliminate the intermediate hosts of pandemic influenza.Host: Adrian Kelly (apk23@cam.ac.uk)
Foxp3, TSLP, and the regulation of immunity and inflammationHost: John Rogers, PDN (jhr11@cam.ac.uk)
Innate crosstalk of unconventional T cells, monocytes and neutrophils in bacterial infectionHost: John Trowsdale (jt233@cam.ac.uk)
Direct Nuclear Pore Complex Regulation of T-cell Induced InflammationHost: Jim Kaufman (jfk31@cam.ac.uk)
Immune profiling the human NK cell repertoire using mass cytometry (CyTOF)Host: Ashley Moffett (am485@cam.ac.uk)
The role of KIR3DL2 HLA-B27 interactions in inflammatory arthritis - symptom or cause?Host: John Trowsdale (jt233@cam.ac.uk)
Preclinical and clinical studies of immunotherapy in type 1 diabetesHost: John Trowsdale (jt233@cam.ac.uk)
Influence of the microbiota on immune system homeostasisHost: Chris Rudd (cer51@cam.ac.uk)
Recognition of herpesviruses by the innate immune systemHost: Brian Ferguson (bf234@cam.ac.uk)
'Dendritic cells and pluripotency: Unlikely allies in the pursuit of immunotherapy'Host: Nick Holmes (nh106@cam.ac.uk)
The evolution of Natural Killer cell receptors: alternative strategies to recognise self and create immune variationHost: Hannah Siddle (hvs26@cam.ac.uk)
Defining a role for Natural Killer cells in HCV infectionHost: Ashley Moffett (am485@cam.ac.uk)
IRF5 in regulation of macrophage inflammatory gene programmeHost: Chris Rudd (cer51@cam.ac.uk)
Defense, counter defense and counter counter defense in host pathogen interactions of plantsHost: Brian Ferguson (bf234@cam.ac.uk)
Lesson from the skin: the Aryl hydrocarbon Receptor (AhR) as an inflammatory brake in psoriasisHost: Anne Cooke (ac@mole.bio.cam.ac.uk)
Using super-resolution microscopy to watch immune cells killHost: John Trowsdale (jt233@cam.ac.uk)
Hepcidin, immunity and global healthHost: Adrian Kelly (apk23@cam.ac.uk)
Toll and TLR function in inflammation and neurogenesisHost: Adrian Kelly (apk23@cam.ac.uk)
Induction of broadly neutralising antibodies against HIV in LlamasHost: Brian Ferguson (bf234@cam.ac.uk)
The importance of MHC protein dynamics for antigen presenting functionHost: Jim Kaufman (jfk31@cam.ac.uk)
LAT signalling pathology: a T-cell dependent, B cell autoimmune condition without T cell self-reactivityHost: Chris Rudd (cer51@cam.ac.uk)
Insights into regulatory genetic variation involving the human MHCHost: John Trowsdale (jt233@cam.ac.uk)
TLR3-IFN deficiencies underlying Herpes simplex encephalitisHost: Brian Ferguson (bf234@cam.ac.uk)
Novel targets to treat hyper-immune syndromes revealed by physiologic responses to DNA nanoparticlesHost: Anne Cooke (ac@mole.bio.cam.ac.uk)
Selection of IgG properties for therapeutic applicationsHost: Jim Kaufman (jfk31@cam.ac.uk)
The existence of species rests on a metastable equilibrium between inbreeding and outbreeding. Trying to explain why Darwin could not solve the mystery of mysteries.Host: Jim Kaufman (jfk31@cam.ac.uk)
Nrp-1: Sticky memories?Host: John Trowsdale (jt233@cam.ac.uk)
Insights into human papillomavirus persistence and cervical carcinogenesis from the W12 model systemHost: Jim Kaufman (jfk31@cam.ac.uk)
Phylogenetic origin of the vertebrate leukocyte receptorsHost: Jim Kaufman (jfk31@cam.ac.uk)
A quantitative view of gene expression levels in the T helper cell systemHost: Nick Holmes (nh106@cam.ac.uk)
MHC haplotyping in rhesus and cynomolgus macaquesHost: Jim Kaufman, jfk31@cam.ac.uk
Elucidating the relative roles of the TCR and CD8 co-receptor in T cell recognition of peptide-MHCIHost: Jim Kaufman (jfk31@cam.ac.uk)
Autoreactive CD4 T Cells and their Antigens in Type 1 DiabetesHost: Anne Cooke (ac@mole.bio.cam.ac.uk)
Surprise, surprise! The molecular evolutionary immunoecology of the ubiquitous protozoal pathogen, Toxoplasma gondiiHost: John Trowsdale, jt233@cam.ac.uk
Memory CD4 T cell generation and survival within secondary lymphoid tissueHost: Jim Kaufman, jfk31@cam.ac.uk
The Aryl Hydrocarbon Receptor: an interpreter of the micro-environmentHost: Jim Kaufman, jfk31@cam.ac.uk
NK cells: turning off the off switchHost: Ashley Moffett, am485@cam.ac.uk
Lessons from pathogens - identifying novel cell surface receptors targeted by virusesHost: Adrian Kelly, apk23@cam.ac.uk
Natural Killers or Natural Protectors? The Role of NK cells During Intestinal InflammationHost: Dr Francesco Colucci, fc287@medschl.cam.ac.uk
Human NK cell activation and inhibition in vivoHost: John Trowsdale, jt233@cam.ac.uk
The chicken leukocyte receptor clusterHost: Jim Kaufman, jfk31@cam.ac.uk
Are mammary epithelial cells specialised immune cells?Host: Jim Kaufman, jfk31@cam.ac.uk
Origin and Transformation of T Cell ProgenitorsHost: Jim Kaufman, jfk31@cam.ac.uk
Protective immunity in HIV infection? A tale of two villagesHost: Ashley Moffett, am485@cam.ac.uk
Positive and negative influences of regulatory T cells in generating the naïve T cell compartmentHost: Nick Holmes, nh106@cam.ac.uk
A genome-wide consideration of genes controlling MHC class II function and beyondHost: John Trowsdale, jt233@cam.ac.uk
Dissecting signals of genetic association to complex diseases within the HLAHost: John Trowsdale, jt233@cam.ac.uk
Membrane rafts in immunoreceptor signaling - reality vs. artefactsHost: Helga Schneider, hs383@cam.ac.uk
What have we learnt about the evolution of the cytokine network from studies in fish?Host: Jim Kaufman, jfk31@cam.ac.uk
Endosomal Feedback at the T-cell Immune SynapseHost: Chris Rudd, cer51@cam.ac.uk
Understanding copy number variation in human antimicrobial defensin genesHost: John Trowsdale, jt233@cam.ac.uk
Modulation of innate immunity by vaccinia virusHost: Jim Kaufman, jfk31@cam.ac.uk
HIV-1 spread between immune cellsHost: Peter Goon, pg336@cam.ac.uk
Stat3: The Secret Ingredient to turn Lysosomes deadly?Host: Jim Kaufman, jfk31@cam.ac.uk
Mechanisms of immune regulation by CTLA-4: Immunology meets cell biologyHost: John Trowsdale, jt233@cam.ac.uk
Imaging Immune Responses In VivoHost: Chris Rudd, cer51@cam.ac.uk
Macrophage paired receptors - structure, interactions and evolutionHost: Jim Kaufman, jfk31@cam.ac.uk
How cells defend their cytosol against bacterial invasionHost: Jim Kaufman, jfk31@cam.ac.uk
Bacterial interference in MHC class II antigen processingHost: Jim Kaufman, jfk31@cam.ac.uk
MHC and disease: a novel hypothesisHost: Jim Kaufman, jfk31@cam.ac.uk
What constitutes a protective HLA class I molecule, and why doesn't it always work?Host: Peter Goon, pg336@cam.ac.uk
What are B cells good for?Host: Jim Kaufman, jfk31@cam.ac.uk
Using our WITS to explore fine structure dynamics of Salmonella and Campylobacter infectionsHost: Jim Kaufman, jfk31@cam.ac.uk
Crosstalk between TLR and Stress pathways: relevance to IL-23 expressionHost: John Trowsdale, jt233@cam.ac.uk
'Pathogenic', 'Protective' and 'Plastic': So what is a Th17 cell?Host: Anne Cooke (ac@mole.bio.cam.ac.uk)
A selective sweep in chimpanzees: Is SIV the culprit?Host: Jim Kaufman, jfk31@cam.ac.uk
Probing lymphocyte activation using single chain MHC class I moleculesHost: Peter Goon, pg336@cam.ac.uk
How pathogens reprogram their host: re-wiring of hematopoietic development during acute infectionHost: Anne Cooke, ac@mole.bio.cam.ac.uk
BG: a rapidly evolving family of cell surface proteinsJim Kaufman, jfk31@cam.ac.uk
Unraveling the long-term evolutionary history of the bird's MHC class IIB: New data and promising perspectivesHost: Professor Jim Kaufman (jfk31@cam.ac.uk)
MHC-dependent sexual and natural selection; insights from ecological studies on birdsHost: Jim Kaufman, jfk31@cam.ac.uk
B lymphocyte regulation of inflammation and autoimmunityHost: Chris Rudd, cer51@cam.ac.uk
Specificity and function of NK cells: interplay between HLA class I and KIR gene polymorphismHost: Ashley Moffett (am485@cam.ac.uk)
NK cells: effectors of vaccine-induced immunity?
The GIMAP/IAN GTPases, regulators of lymphocyte development and survivalHost: John Trowsdale (jt233@cam.ac.uk)
CD4 T cells during Schistosome infection-limiting liver pathology at the cost of obstructing immunityHost: Anne Cooke, ac@mole.bio.cam.ac.uk
Intracellular Immunity: virus neutralisation inside infected cellsHost: John Trowsdale, jt233@cam.ac.uk
Dispersive Salmonella infections: a hit and run strategyHost: Adrian Kelly (apk23@cam.ac.uk)
Molecular organization and signaling at the T-cell surface: system-level and single molecule-based analysisHost: Jim Kaufman, jfk31@cam.ac.uk
Marek's disease virus latency and reactivation: the role of telomeres in integration and mobilization of viral DNAHosts: Truus Abbink, gema2@cam.ac.uk & Jim Kaufman, jfk31@cam.ac.uk
Marek's disease: an excellent natural model for herpesvirus evolution, vaccines, microRNAs and cancerHosts: Jim Kaufman jfk31@cam.ac.uk & Truus Abbink gema2@cam.ac.uk
The immune system in pregnancyHost: Jim Kaufman jfk31@cam.ac.uk
The role of drift and selection in shaping worldwide MHC sequence diversityHost: Jim Kaufman (jfk31@cam.ac.uk)
Understanding T cell differentiation through transgenic and semantic analysis of transcriptomesHost: Nick Holmes (nh106:cam.ac.uk)
Skin inflammation from genes to function and therapyHost: Helga Schneider (hs383@cam.ac.uk)
Evolution of quality control strategies in self/non-self discrimination systemsEXTRA TALK; Host: Jim Kaufman (jfk31@cam.ac.uk)
Evolution of thymopoiesis in vertebratesHost: Jim Kaufman (jfk31@cam.ac.uk)
NKG2D in NK cell physiology: Two sides of the same playerHost: Francesco Colucci (fc287@medschl.cam.ac.uk)
Structural defects of the primary and secondary lymphoid organs in the ageing immune systemHost: Adrian Kelly (apk23@cam.ac.uk)
The IFN system in avian influenza infection in chickensHost: Jim Kaufman (jfk31@cam.ac.uk)
Collagen-binding immune receptors: Form and FunctionHost: John Trowsdale (jt233@cam.ac.uk)
Bridging innate and adaptive immune responses to optimize vaccination strategiesHost: Adrian Kelly (apk23@cam.ac.uk)
Development of synthetic glycolipid agonists for iNKT cell mediated protection from type 1 diabetesTHIS TALK WILL HAPPEN AS SCHEDULED BUT WITH HOST JIM KAUFMAN (JFK31@CAM.AC.UK) DUE TO ASH CLOUD Host: Anne Cooke (ac@mole.bio.cam.ac.uk)
Integration of herpesvirus DNA into host chromosomes - where, when and whyTHIS TALK IS POSTPONED DUE TO ASH CLOUD Hosts: Jim Kaufman (jfk31@cam.ac.uk) & Truus Abbink (gema2@cam.ac.uk)
Maintenance of T helper cell memoryHost: Nick Holmes (nh106@cam.ac.uk)
Controlling secretion at the immunological synapseHost: Nick Holmes (nh106@cam.ac.uk)
Evolution and involution of CD4 memoryHost: Nick Holmes (nh106@cam.ac.uk)
The role of natural killer cells in MSHost: John Trowsdale (jt233@cam.ac.uk); SPONSORED BY Cambridge Research Biochemicals
Imaging T cell activation and functional diversification in vivoHost: Helga Schneider (hs383@cam.ac.uk)
How inhibition leads to activation - the dynamics of natural killer cell educationHost: Francesco Colucci (francesco.colucci@bbsrc.ac.uk)
The role of NK cells and their receptors in cancer and transplantationHost: Ashley Moffett (am485@cam.ac.uk)
Human T cell immunity against tumour antigensHost: Peter Goon (pg336@cam.ac.uk)
T cell responses to EBV: viral evasion, antigen immunodominance and primingHost: Jim Kaufman (jfk31@cam.ac.uk)
New insights into T cell antigen receptor signallingHost: Chris Rudd (cer51@cam.ac.uk)
Immunity and immunopathology in an experimental malaria infectionHost: Anne Cooke (ac@mole.bio.cam.ac.uk)
Temporal and spatial regulation of cell surface proteinase, MT1-MMP: an essential mechanism for cellular invasionHost: Helga Schneider (hs383@cam.ac.uk)
HIV microbicides: current and emerging candidatesHost: Chris Rudd (cer51@cam.ac.uk)
Adaptive variation and evolutionarily conserved MHC-DRB supertype-binding motifs in Old World primatesHost: Jim Kaufman (jfk31@cam.ac.uk)
Regulation of airway remodelling in asthmaHost: Andrew Wyllie
Haplotype-specific transcription in the human MHC and susceptibility to autoimmune diseaseHost: John Trowsdale (jt233@cam.ac.uk); sponsored by Gen-Probe
miRNA-155 regulates immune responsesHost: Anne Cooke (ac@mole.bio.cam.ac.uk)
Reverse Phenotyping: towards an integrated (epi)genomic approach to common disease and complex phenotypesHost: John Trowsdale (jt233@hermes.cam.ac.uk)
Additional layers of complexity in the KIR:MHC systemsHost: Ashley Moffet (am485@cam.ac.uk)
Population genetic puzzles of the MHCHost: John Trowsdale (jt233@cam.ac.uk)
HPV vaccines – will they do their job?Host: Jim Kaufman (jfk31@cam.ac.uk)
Lymphoid tales: TNFAIP8 in glucocorticoid killing – E4BP4 and the origin of NK cellsHost: Ashley Moffet (am485@cam.ac.uk)
A journey through parasite genetics in search of protective antigensHost: Jim Kaufman (jfk31@cam.ac.uk)
Human NK Cell Receptor Diversity Shaped by Natural SelectionHost: John Trowsdale (jt233@cam.ac.uk)
CD22 and Siglec-G: Two inhibitory receptors on B cells with distinct functionsHost: John Trowsdale (jt233@cam.ac.uk)
Notch and peripheral immunityHost: Chris Rudd (cer51@hermes.cam.ac.uk)
The global circulation of seasonal influenza virusesHost: Jim Kaufman (jfk31@cam.ac.uk)
Regulatory T cells inhibit antigen-dependent T cell function but not bystander T cell activity: implications for pathogenesis of RAHost: Helga Schneider (hs383@cam.ac.uk)
Why does HLA-B27 predispose to autoimmune Spondyloarthritis?Host: John Trowsdale (jt233@cam.ac.uk)
Alternatively activated macrophages in helminth infection: a paradigm for Th2 immunityHost: Anne Cooke (ac@mole.bio.cam.ac.uk)
Tolerogenic dendritic cells in chronic helminth infectionHost: Nick Holmes (nh106@cam.ac.uk)
Using natural epitopes to uncover disease mechanisms in autoimmune diabetesHost: John Trowsdale (jt233@cam.ac.uk)
Families of IgSF receptorsHost: Jim Kaufman (jfk31@cam.ac.uk)
Spatio-temporal regulation of signalling during phagocytic uptakeHelga Schneider (hs383@hermes.cam.ac.uk)
Next Generation DNA Sequencing with the Illumina Genome Analyser: Application to bacterial and human genome sequencing and transcriptome analysisHost: Jim Kaufman (jfk31@cam.ac.uk)
Immune regulation in granulomatous inflammation: lessons from LeishmaniaHost: Anne Cooke (ac@mole.bio.cam.ac.uk)
Pathways controlling tolerance to pancreas-expressed antigensHost: Chris Rudd (cer51@hermes.cam.ac.uk)
The Influence of the HLA and KIR loci in HIV diseaseEXTRA TALK! Host: Prof. Ashley Moffet (am485@cam.ac.uk)
Gamma-herpesvirus neutralization: why, when and howHost: Nick Holmes (nh106@cam.ac.uk)
Role of oligomeric assemblies in signal transduction and crosstalk by the TLRsHost: Adrian Kelly (apk23@cam.ac.uk)
Transplantation tolerance: are we getting closer?Host: John Trowsdale (jt233@cam.ac.uk)
Development and function of mucosal NK cells: lymphoid tissue inducer-like cells or NK-22Host: Ashley Moffett (am485@hermes.cam.ac.uk)
A role for Th17 in the development of Type 1 diabetes?host: Jim Kaufman (jfk31@cam.ac.uk)
Decoding the antigen-specific T cell repertoire: immune selection and biological outcomeHost: Dr. Nick Holmes (nh106@cam.ac.uk)
The balance between Th17 and Treg cells - influence of infection and implications for autoimmunityHost: Professor Anne Cooke (ac@mole.bio.cam.ac.uk)
Cancer immunotherapy with gene modified T cellsHost: Prof. John Trowsdale (jt233@cam.ac.uk)
The mechanisms and dynamics of HTLV-1 persistence and spreadHost: Dr. Peter Goon (pg336@cam.ac.uk)
The effect of PECAM-1 gene polymorphism on adhesion and transmigration of leukocytes across endotheliumHost: Dr. Mike Clark (mrc7@cam.ac.uk)
The immune response to HBV: control versus pathogenicityHost: Dr. Helga Schneider (hs383@hermes.cam.ac.uk)
Molecules mediating the surveillance of body surfaces by local T cellsHost: Prof Jim Kaufman (jfk31@cam.ac.uk)
Understanding the role of HLA-B27 in inflammatory arthritisHost: Prof. John Trowsdale (jt233@cam.ac.uk)
CTLA-4 modulation of T-cell anergy and motilityHost: Prof. Jim Kaufman (jfk31@cam.ac.uk)
Please see above for contact details for this list. |
Other listsCambridge Rare Disease Network BHRU Annual Lecture 2016 Fitzwilliam College Foundation LecturesOther talksShort-Selling Restrictions and Returns: a Natural Experiment Finding the past: Medieval Coin Finds at the Fitzwilliam Museum Babraham Lecture - The Remote Control of Gene Expression Leveraging the imaging power of the Beacon platform BOOK LAUNCH: Studying Arctic Fields: Cultures, Practices, and Environmental Sciences Thermodynamics de-mystified? /Thermodynamics without Ansätze? DataFlow SuperComputing for BigData Lecture Supper: James Stuart: Radical liberalism, ‘non-gremial students’ and continuing education Market Socialism and Community Rating in Health Insurance Alzheimer's talks |
Nazma Malik.
Wednesday 12 July 2023, 12:30-13:30