|COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring.|
Using super-resolution microscopy to watch immune cells kill
If you have a question about this talk, please contact Sue Griffin.
Host: John Trowsdale (firstname.lastname@example.org)
Cell-contact dependent regulation of immune cell responses plays a vital role in balancing the need for rapid and efficient responses to a wide variety of pathological challenges, while at the same time maintaining self-tolerance. Over the last decade, much research has studied how immune cell interactions are often accompanied by the segregation of proteins into micrometer- and submicrometer-scale domains at an immune synapse.
The emerging new paradigm is that interactions between immune cell receptors, kinases and adaptors are at least in part controlled by transient interactions between supramolecular assemblies. This is a significantly different concept from a linear cascade of individual protein-protein interactions depicted in textbook diagrams of immune receptor signaling pathways.
Here, I will present new data using high- and super-resolution imaging techniques that reveal novel insights into molecular recognition by human Natural Killer cells and how specific effector functions are realized. Our data reveal, for example, that remodelling of the cortical actin mesh occurs at the central region of the NK cell immune synapse during a cytolytic response. This is likely to occur for other types of cell secretion and emphasises the importance of emerging super-resolution imaging technology for revealing new biology.
This talk is part of the Immunology in Pathology series.
This talk is included in these lists:
Note that ex-directory lists are not shown.
Other listsPalestinians in Israel: Segregation, Discrimination and Democracy Ffion Hague - 'The Women in Lloyd George's Life Future of Sustainable Development in South Asia
Other talksTBC Cambridge in the Fifties and Sixties: an extended conversation 2015 Alcuin Lecture - 'Our infinite Scotland small?' Choosing worlds to join. Koopman operator theory in fluid mechanics TBC Creation, Collaboration, Contemplation: Academic Libraries and the Digital Revolution