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Reverse Phenotyping: towards an integrated (epi)genomic approach to common disease and complex phenotypes

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If you have a question about this talk, please contact Prof. Jim Kaufman.

Host: John Trowsdale (jt233@hermes.cam.ac.uk)

The laboratory has broad interests in the genomics of phenotypic plasticity in health and disease. In addition to polymorphisms and mutations, we study epigenetic changes such as DNA methylation and histone modifications that can modulate genome function under exogenous influence.

Central to our research is the development of an integrated systems approach – termed ‘reverse phenotyping’ – to screen genomes of common diseases as well as cancer for genetic, epigenetic and combinatorial variations. The ability to distinguish causal from consequential variations is one of the key challenges in biomedical research. Once fully established, ‘reverse phenotyping’ can be expected to significantly increase our ability to identify novel and, in particular, combinatorial variations causing or contributing to phenotypic plasticity and thus will provide new targets for translation into diagnostics and therapeutics.

This talk is part of the Immunology in Pathology series.

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