|COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring.|
IRF5 in regulation of macrophage inflammatory gene programme
If you have a question about this talk, please contact Sue Griffin.
Host: Chris Rudd (email@example.com)
Recently, we have discovered that transcription factor IRF5 plays a direct role in establishing a pro-inflammatory phenotype of macrophages. Macrophages are immune cells that are essential for the initiation and resolution of pathogen- or tissue damage-induced inflammation. They demonstrate remarkable plasticity that allows them to efficiently respond to environmental signals and change their phenotype and physiology in response to cytokines and microbial signals.
We have demonstrated that IRF5 directs transcriptional activation of the majority of pro-inflammatory cytokines, chemokines and co-stimulatory molecules and begun to dissect the molecular mechanisms of IRF5 directed gene regulation. Moreover, genetic polymorphisms in the IRF5 gene, leading to increased IRF5 mRNA expression, are associated with a number of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjogren’s syndrome, multiple sclerosis and inflammatory bowel disease.
Our current understanding of the molecular events in immune cells responsible for IRF5 pathogenic function during the inflammatory response will be discussed.
This talk is part of the Immunology in Pathology series.
This talk is included in these lists:
Note that ex-directory lists are not shown.
Other listsGlobal Student Education Forum (GSEF) 'Expanding Horizons' - Cambridge MedSoc Talks Future of Sustainable Development in South Asia
Other talksOvercoming Chromatin Barriers to Elicit Cell Fate Changes A trick of the light? Development, function and evolution of plant nanostructures that influence animal behaviour Detecting change-points in the structure of a network: Exact Bayesian inference Prof Benedikt Kaufer: Herpesvirus latency: From neuronal models to integration into host telomeres On the Statistical Estimation of the Preferential Attachment Network Model Molecular characterization of the Flagellar Pocket Collar cytoskeletal of the protozoan parasite Trypanosoma brucei