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The role of natural killer cells in MS

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If you have a question about this talk, please contact Prof. Jim Kaufman.

Host: John Trowsdale (jt233@cam.ac.uk); SPONSORED BY Cambridge Research Biochemicals

Danny Altmann is in the Department of Medicine at Imperial College where he is Director of Research Strategy. His lab have for many years used a combination of human, clinical studies and ‘humanised’ transgenic approaches to investigate pMHC/TCR interactions in infectious and autoimmune disease. Currently, half of his lab is devoted to studies of T cell and NK cell responses in multiple sclerosis, while the remainder work on the T cell immunology of bacterial sepsis, particularly strep, anthrax and burkholderia.

Recent publications include:

• Campbell JD et al., (2009). Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. J Exp Med. 206(7):1535-47

• Kaushansky N et al., (2009). HLA -DQB1 0602 determines disease susceptibility in a new “humanized” multiple sclerosis model in HLA -DR15 (DRB1 1501; DQB1 0602 ) transgenic mice. J Immunol. 183(5):3531-41.

• Reynolds C, et al., (2009). Natural killer T cells in bronchial biopsies from human allergen challenge model of allergic asthma. J Allergy Clin Immunol. 124(4):860-2

• Ingram, R.J et al., 2010. Natural exposure to cutaneous anthrax gives long-lasting T cell immunity encompassing infection-specific epitopes. J. Immunol, in press

This talk is part of the Immunology in Pathology series.

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