Direct Nuclear Pore Complex Regulation of T-cell Induced Inflammation

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• Professor Chris Rudd, Dept of Pathology, University of Cambridge
• Wednesday 24 April 2013, 12:30-13:30
• Lecture Theatre, Department of Pathology, Tennis Court Road.

If you have a question about this talk, please contact Sue Griffin.

Host: Jim Kaufman (jfk31@cam.ac.uk)

We are interested in the receptor-mediated signals that regulate the activation and function of T-cells. The antigen-receptor complex (TCR) activates T-cells via the activation of src kinases and ZAP -70 leading to the phosphorylation of the adaptor protein linker for the activation of T-cells (LAT). Despite its importance, it has been unclear whether LAT is solely coupled to the TCR , or whether it can undergo changes in composition in the regulation of T-cell function.

I will present data showing that co-receptors can alter the composition of the LAT signalosome by displacing associated GADs-SLP-76 complexes. These observations show for the first time that co-receptors can intersect directly with TCR signaling by altering the composition of the LAT signalosome in T-cells.

In the second part of my talk, I will discuss recent work showing that the adaptors can directly bind and modulate the nuclear pore complex (NPC) in T-cells for the transport of transcription factors such as NFAT , needed for the production of pro-inflammatory cytokines.

This talk is part of the Immunology in Pathology series.

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