University of Cambridge > > BSS Formal Seminars > An intracellular organization of extracellular information

An intracellular organization of extracellular information

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Although cells respond specifically to environments, how environmental identity is encoded intracellularly is not understood. Here I will discuss this organization of information in budding yeast by estimating the mutual information between environmental transitions and the dynamics of nuclear translocation for ten transcription factors. Information is transduced through two channels – generalists and specialists – and transcription factors report differently and collectively can provide more information than predicted by noise-averaging. Changes in nuclear localization of multiple transcription factors thus constitute a precise, multi-dimensional internal representation of complex environments.

This talk is part of the BSS Formal Seminars series.

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