Circulating tumour cells: a model from breast cancer to bone metastasis

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• Dr Gianluca Ascolani
• Wednesday 24 February 2016, 14:00-15:00
• MR4, Centre for Mathematical Sciences, Wilberforce Road, Cambridge.

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Ductal carcinoma is one of the most common cancers among women, and the main cause of death is the formation of metastases. The development of metastases is caused by cancer cells that migrate from the primary tumour site (the mammary duct) through the blood vessels and extravasating, they initiate metastasis (preferentially in the bone tissue). We present a multi-compartment model that aims at elucidating the effects of the TGF - and the concomitant therapies in the three microenvironments: mammary duct, circulatory system and bone niche. Starting from the gene expression profile of circulating tumour cells and clinical data, we use the model in order to predict the patient-specific survival and to explain the role of circulating tumour cells in the progression of the disease providing a quantitative measure of the cell driver mutations needed for invading the bone tissue.

This talk is part of the Computational and Systems Biology series.

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