Into the void: bridging the gap between risk genes and psychiatric phenotypes.

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• Dr Elizabeth Tunbridge, Department of Psychiatry, University of Oxford
• Thursday 08 October 2015, 14:00-15:00
• Biffen Lecture Theatre, Department of Genetics, Downing Site.

If you have a question about this talk, please contact Caroline Newnham.

Host: Cahir O' Kane

Recent genome-wide association studies have identified risk factors that are robustly associated with psychiatric disorders. However, moving from the knowledge that ‘Variant X is associated with Disorder Y’, to an understanding of the underlying causative mechanisms, and, ultimately, to novel, rational treatments, is a mammoth task. I will explore potential strategies to address this challenge. As well as drawing from findings from the wider field, I will illustrate this argument using examples from my own research. First, I will show how translating, and back-translating, between animal models and studies in human volunteers, can provide understanding of the mechanisms by which genes of interest can be linked with whole brain function, as well as generating novel hypotheses. I will then outline how human neuroimaging can provide clues to the neurobiological effects of genes whose function is unknown in the brain.

This talk is part of the Genetics Seminar series.

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