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High resolution models of genome regulatory events

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  • UserProf. David Gifford (MIT)
  • ClockMonday 09 October 2006, 16:30-17:30
  • HouseMR2, DAMTP.

If you have a question about this talk, please contact Gos Micklem.

This lecture is part of the Distinguished Seminar Series run by the CCBI.

David’s group has had a long-standing collaboration with Rick Young’s lab at the Whitehead Institute and this has resulted in many seminal papers.


Understanding how transcription factors and chromatin modifiers regulate gene expression is a central problem in biology. A new computational approach, Joint Binding Deconvolution, permits the location of protein-genome binding events to be determined at high spatial resolution from chromatin immunoprecipitation experiments (ChIP-Chip). We have combined ChIP-Chip data with expression data and genome sequence to reveal regulatory networks in yeast and components of the core network that regulates pluripotency in human embryonic stem cells.

This talk is part of the Computational and Systems Biology series.

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