Transcription regulation: from parts list to genomic network.

Add to your list(s) Download to your calendar using vCal

• Nicholas Luscombe
• Wednesday 06 December 2006, 14:00-15:00
• Ryle Seminar Room, Cavendish Laboratory.

If you have a question about this talk, please contact Ryan Prescott Adams.

The transcriptional regulatory system plays a central role in directing gene expression changes in response to internal and external stimuli. In this talk, first I wll present our work on transcription regulation in yeast, ranging from large-scale experimental studies to computational analyses of regulatory networks. I will introduce results from ChIP-chip experiments that identify genome-wide DNA -binding sites of transcription factors, particularly focusing on the cell cycle regulatory system. I will discuss how these observations fit in to an idea of a genomic regulatory network, and examine the effects of such networks on gene expression. Later, I will introduce preliminary results of our analysis of the transcriptional regulatory system in the human genome.

Vaquerizas JM, Kummerfeld SK, Dopazo J, Teichmann SA & Luscombe NM. A functional census of human transcription factors. (submitted).

Luscombe NM, Babu MM, Yu H, Snyder M, Teichmann SA & Gerstein M. Genomic analysis of regulatory network dynamics. Nature 431, 308-312.

Babu MM, Luscombe NM, Aravind L, Gerstein M & Teichmann SA. Structure and evolution of transcriptional regulatory networks. Current Opinions in Structural Biology, 14, 283-291.

Yu H, Luscombe NM, Qian J & Gerstein M. Genome-wide analysis of gene expression relationships in transcriptional regulatory networks. Trend in Genetics, 19, 422-427.

Horak C E , Luscombe N M , Qian J, Bertone P, Piccirillo S, Gerstein M & Snyder M. (2002). Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Genes and Development , 16, 3017-3033.

For further information about our group’s work: http://www.ebi.ac.uk/luscombe

This talk is part of the Inference Group series.

This talk is included in these lists:

• All Cavendish Laboratory Seminars
• All Talks (aka the CURE list)
• Bertone Group
• Biology
• Biology
• Cambridge Neuroscience Seminars
• Cambridge talks
• Centre for Health Leadership and Enterprise
• Chris Davis' list
• Featured lists
• Guy Emerson's list
• Hanchen DaDaDash
• Inference Group
• Inference Group Summary
• Interested Talks
• Joint Machine Learning Seminars
• Life Science
• Life Sciences
• Life Sciences
• ME Seminar
• ML
• Machine Learning Summary
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• Neuroscience
• Neuroscience Seminars
• Neuroscience Seminars
• Required lists for MLG
• Ryle Seminar Room, Cavendish Laboratory
• School of Physical Sciences
• Stem Cells & Regenerative Medicine
• Thin Film Magnetic Talks
• dh539
• kt532's list
• my_list
• other talks
• rp587
• yk373's list

Note that ex-directory lists are not shown.