Ligand detection and discrimination by spatial relocalisation: the complexities of T cell activation

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• Nigel Burroughs (Dept of Mathematics, University of Warwick)
• Wednesday 28 June 2006, 17:00-18:00
• Part 2 Seminar Room (First Floor), Craik-Marshall Building.

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We analyse a theory of ligand triggering based on receptor relocation to regions of low phosphatase activity. The application is cell:cell communication and receptors where there is no known conformation change, but possessing short ectodomains. Through spatial segregation of long and short bonds/molecules in the cell:cell interface, large phosphatases can be excluded from regions of close contact. In these regions small receptors get trapped by binding to their ligands. We examine the sensitivity and specificity of such as system using a spatial lattice model and molecule diffusion and the requirements for it to have efficient detection characteristics.

This talk is part of the Computer Modelling in Biology series.

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