Physico-chemical properties of colloids, their interaction with cells, and some applications

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• Prof Wolfgang Parak, Biophotonics Group, University of Marburg, Marburg Germany
• Friday 17 January 2014, 14:00-15:00
• Small Lecture Theatre, Cavendish Laboratory.

If you have a question about this talk, please contact Dr Eileen Nugent.

Modern synthesis methods allow for obtaining colloidal nano- and microparticles with highly defined properties. With these particles detailed studies about their interaction with the environment are possible. This will be described for the cases of adsorption of counter ions and proteins [1, 2] and impact on interaction with cells will be discussed [3, 4]. Some in vitro sensing and delivery applications will be highlighted [5, 6].

[1] P. Rivera Gil, D. Jimenez de Aberasturi, V. Wulf, B. Pelaz, P. del Pino, Y. Zhao, J. de la Fuente, I. Ruiz de Larramendi, T. Rojo, X.-J. Liang, W. J. Parak, “The Challenge To Relate the Physicochemical Properties of Colloidal Nanoparticles to Their Cytotoxicity”, Account of Chemical Research 46, 743–749 (2013). [2] M. Mahmoudi, A. M. Abdelmonem, S. Behzadi, J. H. Clement, S. Dutz, M. R. Ejtehadi, R. Hartmann, K. Kantner, U. Linne, P. Maffre, S. Metzler, M. K. Moghadam, C. Pfeiffer, M. Rezaei, P. Ruiz-Lozano, V. Serpooshan, M. A. Shokrgozar, G. U. Nienhaus, W. J. Parak, “Temperature Effects at the Nano-Bio Interface”, ACS Nano 7, 6555–6562 (2013). [3] D. Hühn, K. Kantner, C. Geidel, S. Brandholt, I. De Cock, S. J. Soenen, P. Rivera Gil, J. M. Montenegro Martos, K. Braeckmans, K. Müllen, G. U. Nienhaus, M. Klapper, W. J. Parak, “Polymer-coated nanoparticles interacting with proteins and cells: Focusing on the sign of the net charge”, ACS Nano 7, 3253–3263 (2013). [4] M. Chanana, P. Rivera Gil, M. A. Correa-Duarte, L. M. Liz-Marzán. W. J. Parak, “Physicochemical Properties of Protein-Coated Gold Nanoparticles in Biological Fluids and Cells before and after Proteolytic Digestion”, Angewandte Chemie 52, 4179–4183 (2013). [5] L. L. del Mercato, A. Z. Abbasi, M. Ochs, W. J. Parak, “Multiplexed Sensing of Ions with Barcoded Polyelectrolyte Capsules”, ACS Nano 5, 9668–9674 (2011). [6] M. Ochs, S. Carregal-Romero, J. Rejman, K. Braeckmans, S. C. De Smedt, W. J. Parak, “Light-Addressable Capsules as Caged Compound Matrix for Controlled Triggering of Cytosolic Reactions”, Angewandte Chemie 52, 695-699 (2013).

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