University of Cambridge > > Genetics Seminar  > Structural insights into the molecular mechanisms of accurate chromosome segregation.

Structural insights into the molecular mechanisms of accurate chromosome segregation.

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If you have a question about this talk, please contact Caroline Newnham.

Host: Viji Draviam

Accurate chromosome segregation involves highly orchestrated mitotic events such as chromosome condensation, attachment of microtubules to the sister chromatids via the kinetochores, movement of sister chromatids towards the spindle poles and cytokinesis. Such a complicated network of events that takes place between the onset and exit of mitosis is regulated by a number of molecular assemblies (including condensin, cohesin, Chromosomal Passenger Complex (CPC), KMN (Knl1-Mis12-Ndc80) network, Ska complex, spindle checkpoint assembly and the anaphase promoting complex) involving an extensive network of protein-protein interactions.

Among the key molecular interactions, those involving the CPC and the Ska complex are currently being investigated in our lab, mainly due to their essential role in kinetochore-microtubule attachments and in timely mitotic progression. While the CPC , with its enzymatic core Aurora B kinase, orchestrates various mitotic events from chromosome condensation to cytokinesis by phosphorylating the right substrate at the right place and time, the Ska complex physically couples chromosomes to the spindle MTs by interacting with KT-associated proteins and is implicated in the timely onset of anaphase. During the talk, I will be discussing our efforts to understand the structural and functional role of these protein complexes in achieving accurate cell division.

This talk is part of the Genetics Seminar series.

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