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Immune-metabolic interaction in Drosophila.

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If you have a question about this talk, please contact Caroline Newnham.

Host: Boris Adryan

Immune responses and metabolic regulation are intimately linked in all animals. However, our understanding of the mechanistic underpinnings of this linkage is incomplete. I will present two different aspects of metabolic-immune interaction in Drosophila. In the first part of the talk, I will present our recent data showing that the transcription factor MEF2 is a critical switch between immune function and metabolic storage. Flies lacking MEF2 in the fat body exhibit dramatic reductions in storage of triglyceride and glycogen and are simultaneously severely immunocompromised; we have shown that these phenotypes reflect distinct transcriptional functions of MEF2 , and that the loss of “metabolic” MEF2 contributes to the loss of anabolic enzyme expression in Gram-negative bacterial infection. In the second part of the talk, I will discuss the role of the Drosophila cytokine upd3 in regulation of phagocyte bactericidal activity and cellular lipid metabolism during mycobacterial infections.

This talk is part of the Genetics Seminar series.

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