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Genomic Approaches to Cancer

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  • UserTodd Golub, Broad Institute of MIT and Harvard, Dana-Farber Cancer Institute
  • ClockThursday 16 November 2017, 13:00-14:00
  • HouseCRUK CI Lecture Theatre.

If you have a question about this talk, please contact Kate Davenport.

It is now becoming possible to bring powerful genomic methods to bear on the process of cancer drug discovery. This talk will illustrate 1) the use of the Connectivity Map, a large-scale effort to develop a compendium of gene expression signatures of cellular state, 2) the use of PRISM , a new multiplexed, high throughput approach to screening cancer cell lines for anti-cancer activity and resistance, and 3) the use of cancer models (cell lines and patient-derived xenografts) in discovery, with particular focus on clonal drift in these models and the impact of that drift on drug sensitivity.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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