How does the kinetochore orchestrate a functional checkpoint signal?

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• Professor Jakob Nilsson from The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
• Thursday 10 October 2013, 14:30-15:30
• Part II Room, Department of Genetics.

If you have a question about this talk, please contact Caroline Newnham.

Host: Viji Draviam

The proper segregation of sister chromatids during mitosis depends on the Spindle Assembly Checkpoint (SAC), which delays anaphase onset until all kinetochores have attached to microtubules. The SAC inhibits the APC /C-Cdc20 complex, a large ubiquitin ligase required for anaphase onset, by the direct binding of two SAC proteins Mad2 and BubR1 to Cdc20. Cdc20 is only inhibited when incorrectly attached kinetochores are present which correlates with the localization of SAC proteins to the kinetochore. The recruitment of SAC proteins to the kinetochore is believed to be important for generating a functional checkpoint signal but exactly how this is achieved at the molecular levels is unclear. I will present our recent progress in understanding how the SAC proteins interact with the kinetochore and how this contributes to generating a functional checkpoint signal.

This talk is part of the Genetics Seminar series.

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