University of Cambridge > > BSS Formal Seminars > Engineered protein pores in nanotechnology and single-enzyme studies

Engineered protein pores in nanotechnology and single-enzyme studies

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One goal of nanotechnology is the manufacture of tiny machines from simple parts; another is the observation of single-molecule. Proteins and DNA are ideal building blocks in nanotechnology because they can be precisely and reproducibly fabricated with atomic precision in large quantity. Artificial devices made of natural components have the crucial advantage over their synthetic equivalents of being able to interface with biological systems. Towards this end, we built a nanopore:DNA systems that is capable of controlling the transport of nucleic acids across biological membranes. We also redesigned nanopore:protein systems that can recognize specific protein substrates and allow the observation of folding, activity and dynamics of single-enzymes.

This talk is part of the BSS Formal Seminars series.

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