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Denaturation transition of stretched DNA in the presence of DNA-binding ligands

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Topological Dynamics in the Physical and Biological Sciences

Stretching experiments on DNA in the presence of DNA binding ligands have been shown to reveal insight into biological processes of DNA -ligand binding. We generalize the Poland-Scheraga model to consider DNA denaturation in the presence of an external stretching force and DNA -binding ligands which bind to double-stranded DNA by intercalating between two adjacent base pairs. We obtain the phase diagram of DNA denaturation as a function of temperature, stretching force, and the chemical potential of the DNA -binding ligand. Force-extension relations are compared with recent DNA stretching experiments in the presence of DNA intercalating ethidium and ruthenium complexes.

This talk is part of the Isaac Newton Institute Seminar Series series.

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