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Genetic Screens in Embryonic Stem Cells

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If you have a question about this talk, please contact Dr Nigel Bennee.

In 1984 Liz Robertson and I demonstrated that embryonic stem (ES) cells could be transmitted through the germ line of mice and two years later reported that ES cells could be used to generate mice with mutations in endogenous genes. This work contributed to the award of the Nobel Prize in Physiology or Medicine to Martin Evans in 2007.

Mice can be generated with changes as subtle as an alteration in a single nucleotide or as massive as the deletion, duplication or inversion of millions of base pairs, a technology that has become known as chromosome engineering. My laboratory has used ES cell technology extensively, generating and analysing many of the first generation of mouse knockouts as well as helping numerous other laboratories to utilize this technology. This work has provided key functional information on many genes with an emphasis on cancer, DNA repair and embryonic development.

This talk is part of the Cambridge Society for the Application of Research (CSAR) series.

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