Many ways to make ends meet: orchestration of DNA double-strand break repair processes by the NHEJ pathway

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• Prof. Aidan Doherty - Genome Damage & Stability Centre, University of Sussex.
• Thursday 10 March 2011, 14:30-15:30
• Part II room, Department of Genetics.

If you have a question about this talk, please contact Becky Baglow.

Non homologous end-joining (NHEJ) is an essential DNA double-strand break (DSB) repair pathway required to maintain genome stability. We are using model unicellular organisms (bacteria and yeast), combined with biochemical and structural approaches, to understand both the mechanism and regulation of the NHEJ pathway. The simplicity of these DSB repair complexes makes them ideal models for studying both the cellular and molecular mechanisms that co-ordinate the processing and joining of DSBs by the NHEJ pathway and also provides a conceptual framework for understanding related break repair processes in higher eukaryotes.

References: Weller et al. (2002) Science 297, 1686-1689. Della et al. (2004) Science 306, 683-685. Hentges et al. (2007) J. Biol. Chem. 281, 37517–37526. Pitcher et al. (2007) Ann. Rev. Microbiol. 61, 258-282. Brissett et al. (2007) Science 318, 456-459.

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