“Self-protection of the early embryo: a dynamic perspective on phagocytosis in natural environments”

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• Dr Esteban Hoijman. Embryonic Cell Bioimaging lab, Molecular Biology Institute of Barcelona, IBMB-CSIC/IDIBELL
• Thursday 06 March 2025, 16:00-17:00
• Hodgkin Huxley Seminar Room, Physiology building, Downing Site CB2 3EG.

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Early embryogenesis is a highly plastic stage, capable of overcoming a wide range of perturbations. Significant efforts have been dedicated to understanding how pluripotent cells adapt their developmental programs in response to deviations. However, how the embryo protects its cells from these perturbations without possessing its own immune system remains poorly understood. Our previous research revealed that epithelial cells on the embryonic surface (trophectoderm in mammals) can eliminate apoptotic cells through phagocytosis. Here, I will present our latest findings demonstrating that the early embryo can also clear infectious agents. Using a quantitative live imaging approach, we investigate this process across biological scales in zebrafish, mouse, and human embryos. Additionally, our model serves as a platform to study the phagocytic dynamics of microorganisms carried out by epithelial tissues in natural environments.

This talk is part of the Foster Talks series.

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