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The stochastic mechanical brain

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USMW02 - Mathematical mechanical biology: old school and new school, methods and applications

Fuelled in particular by current medical challenges in Traumatic Brain Injury, the field of brain mechanics has progressed tremendously in the last decade. Simulations that required months in development and runtime can now be created from patient specific medical images, meshed and run in a fraction of that time. However, and maybe paradoxically, the high fidelity of these new models has exacerbated a problem that the rough early finite element models were naturally avoiding by design, i.e., the stochasticity of the brain. In this presentation, we propose a series of new numerical methods built on the finite element method accounting for both the intrinsic stochasticity (i.e., variations of the properties within the brain) and extrinsic stochasticity (i.e., variations between individuals). Relevant applications are given throughout as illustrations.

This talk is part of the Isaac Newton Institute Seminar Series series.

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