The role of mechanics in the maintenance of epithelial barrier integrity.

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• Benoit Ladoux (Institut Jacques Monod)
• Thursday 06 July 2023, 09:00-10:00
• Seminar Room 1, Newton Institute.

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SPLW01 - Building a bridge between non-equilibrium statistical physics and biology

Epithelia are communities of epithelial cells with close intercellular communications and of highly ordered coordination in their motility. Tissues can adjust their internal contractile stresses and organization in response to different stimuli, leading to distinct dynamics. Mechanical properties of epithelial tissues are important for our understanding in many vital biological processes, including homeostasis, morphogenesis, and metastasis and are tightly regulated by cell-cell interactions. I will present examples highlighting the importance of collective behaviours to understand tissue regulation. In the first part, I will focus on the role of cell extrusion and how mechanics can regulate the fate of extruding cells. Then, I will show how substrate rigidity can alter tissue integrity and lead to the formation of holes resulting from large stress fluctuations.

This talk is part of the Isaac Newton Institute Seminar Series series.

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