Mapping DNA replication stress in parasites and cancer cells with long-read sequencing and AI

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• Dr. Michael A. Boemo, Research Group Leader, Department of Pathology
• Wednesday 15 February 2023, 14:00-15:00
• CMS, Meeting Room 15.

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Every time a cell divides, it must copy (or “replicate”) its genome exactly once, which it achieves through the parallel action of thousands of replication forks. One of the most serious errors in DNA replication occurs when replication forks stall, which happens when the fork encounters an obstacle that it cannot pass. The frequent slowing or stalling of replication forks, termed “replication stress”, is rare in healthy human cells but common in both cancer cells and parasites. Replication stress is therefore a common therapeutic target for anti-malarial and cancer chemotherapies, but we have a relatively poor understanding of where, when, why, and how often replication forks stall under these therapies. I will discuss our recent progress towards answering these questions, whereby we are using long-read nanopore DNA sequencing together with AI to measure the movement and stress of thousands of replication forks across the genomes of human cancer cells and the malaria parasite Plasmodium falciparum.

This talk is part of the Computational and Systems Biology Seminar Series 2023 - 24 series.

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