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Computational approaches to Immuno-Oncology drug development

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Abstract: Immune modifying approaches for the treatment of cancer have been wildly successful, yet approved therapies are only the tip of the iceberg. Drugs in earlier stages of development represent a broad class of agents with numerous challenges for a successful drug discovery programme. For example, how do we demonstrate intra-tumoural immune modulation from a peripheral blood sample? How do identify the patients most likely to respond to immune-therapy? Here I will discuss the bioinformatic approaches we are taking to address these questions within AstraZeneca.

This talk is part of the Computational and Systems Biology series.

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