Computational Neuroscience Journal Club

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• David Zoltowski (University of Cambridge)
• Tuesday 10 November 2015, 16:00-17:00
• Cambridge University Engineering Department, CBL, BE-438 (http://learning.eng.cam.ac.uk/Public/Directions).

If you have a question about this talk, please contact Guillaume Hennequin.

David Zoltowski will cover:

• Single-trial spike trains in parietal cortex reveal discrete steps during decision-making
• K W Latimer, J L Yates, M L R Meister, A. C. Huk and J. W. Pillow
• http://www.sciencemag.org/content/349/6244/184.abstract

Neurons in the macaque lateral intraparietal (LIP) area exhibit firing rates that appear to ramp upward or downward during decision-making. These ramps are commonly assumed to reflect the gradual accumulation of evidence toward a decision threshold. However, the ramping in trial-averaged responses could instead arise from instantaneous jumps at different times on different trials. We examined single-trial responses in LIP using statistical methods for fitting and comparing latent dynamical spike-train models. We compared models with latent spike rates governed by either continuous diffusion-to-bound dynamics or discrete “stepping” dynamics. Roughly three-quarters of the choice-selective neurons we recorded were better described by the stepping model. Moreover, the inferred steps carried more information about the animal’s choice than spike counts.

This talk is part of the Computational Neuroscience series.

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