|COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring.|
Dynamics of molecular clocks expose the lineage relations of cells
If you have a question about this talk, please contact Florian Markowetz.
Understanding the embryonic development and post-natal maintenance in multi-cellular organisms requires advanced methods for cell lineage reconstruction of individual cells. The mammalian female germline is a classic example in which the fundamental aspects of these processes remain highly debatable, with doubts as to the clonal relation between adult stem cells and primordial germ cells, as well as conflicting evidence of post-natal oocyte renewal. We developed a high-throughput method for reconstructing cell lineage trees from genomic variability caused by somatic mutations in microsatellite molecular clocks. We have reconstructed lineage trees of hundreds of oocytes and other cell types, sampled from mismatch-repair deficient mice at various ages. Analysis of these trees sheds light on the lineage relations between oocytes and bone-marrow derived cells, on the nature of the migration-expansion process of primordial germ cells and on the dynamics of oocyte aging.
Hosted by Nitzan Rosenfeld.
This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.
This talk is included in these lists:
Note that ex-directory lists are not shown.
Other listsCombining chemical-genetic with metabolic profiling to study a dynamic metabolic transition Aitken Lectures Engineering for Clinical Practice
Other talksInstabilities in shear-thinning viscoelastic fluids: a long story Play & Current Neuroscience Research - Dr Lindsey Russo Developing antibiotic alternatives: A discussion of new approaches to overcoming antimicrobial resistance The Search for Innovation in Psychiatry TB Summit 2016 Annual General Meeting