|COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring.|
Dynamics of molecular clocks expose the lineage relations of cells
If you have a question about this talk, please contact Florian Markowetz.
Understanding the embryonic development and post-natal maintenance in multi-cellular organisms requires advanced methods for cell lineage reconstruction of individual cells. The mammalian female germline is a classic example in which the fundamental aspects of these processes remain highly debatable, with doubts as to the clonal relation between adult stem cells and primordial germ cells, as well as conflicting evidence of post-natal oocyte renewal. We developed a high-throughput method for reconstructing cell lineage trees from genomic variability caused by somatic mutations in microsatellite molecular clocks. We have reconstructed lineage trees of hundreds of oocytes and other cell types, sampled from mismatch-repair deficient mice at various ages. Analysis of these trees sheds light on the lineage relations between oocytes and bone-marrow derived cells, on the nature of the migration-expansion process of primordial germ cells and on the dynamics of oocyte aging.
Hosted by Nitzan Rosenfeld.
This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.
This talk is included in these lists:
Note that ex-directory lists are not shown.
Other listsSustainable Resources Research Group Talk on the invention of the chronograph Babraham Institute Events
Other talksScott Lecture III - title tbc 'The River Ganges running red: reversing the divine' Climate Change and International Trade BHRU Annual Lecture 2016 - Electronic cigarettes: a disruptive technology? Strategies for managing social media research data – A digital methods development workshop organised by Cambridge University Library and the Digital Humanities Network. The mass function of stars and black holes in globular clusters