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Dynamics of molecular clocks expose the lineage relations of cells

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If you have a question about this talk, please contact Florian Markowetz.

Understanding the embryonic development and post-natal maintenance in multi-cellular organisms requires advanced methods for cell lineage reconstruction of individual cells. The mammalian female germline is a classic example in which the fundamental aspects of these processes remain highly debatable, with doubts as to the clonal relation between adult stem cells and primordial germ cells, as well as conflicting evidence of post-natal oocyte renewal. We developed a high-throughput method for reconstructing cell lineage trees from genomic variability caused by somatic mutations in microsatellite molecular clocks. We have reconstructed lineage trees of hundreds of oocytes and other cell types, sampled from mismatch-repair deficient mice at various ages. Analysis of these trees sheds light on the lineage relations between oocytes and bone-marrow derived cells, on the nature of the migration-expansion process of primordial germ cells and on the dynamics of oocyte aging.

Hosted by Nitzan Rosenfeld.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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