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ChIP-Seq in six Drosophila species reveals a highly similar binding landscape for the developmental transcription factor Twist.

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If you have a question about this talk, please contact Florian Markowetz.

Gene expression during development is controlled by transcription factors that bind to cis-regulatory sequences. Transcription factors and their target genes are often highly conserved, yet the evolutionary dynamics of their binding sites has remained unclear. Here, we report the first systematic ChIP-seq analysis of a key developmental transcription factor across six Drosophila species at a wide range of evolutionary distances. We find that the entire binding landscape for the mesodermal transcription factor Twist is highly similar across species. This includes high-occupancy sites, as well as over 10,000 low-occupancy sites near the detection limit.

We find that conserved binding sites are clustered and strongly correlate with sequence motifs for Twist and its partners, permitting the de novo discovery of these regulators. Conserved low-occupancy sites tend to be occupied at different developmental stages, providing an explanation for the high abundance of binding sites for many transcription factors and suggesting that transcription factors can bind to inactive enhancers, potentially marking or preparing them for future activation.

Hosted by Duncan Odom.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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