Neurotransmitter receptor gradients: gateways for subcortical routing of cortex-wide dynamics during cognition
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Recent advances in connectomics and neurophysiology make it possible to probe whole-brain mechanisms of cognition and behavior. However, as yet, few models in computational neuroscience have tackled the mechanisms underlying highly distributed neural activity during cognition. In this talk I will describe our anatomy-led approach to developing cortex-wide models of neural dynamics during cognitive tasks and our recent anatomical findings of graded expression of neurotransmitter receptors in the cortex. I will highlight our investigations into how inputs from the thalamus and neuromodulatory systems may shift the cortical dynamical landscape, and how this may confer flexibility on distributed cognitive functions such as conscious perception and working memory.
This talk is part of the Computational Neuroscience series.
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Seán Froudist-Walsh, U Bristol
Tuesday 19 March 2024, 10:00-11:00