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Analysing the pharmacokinetics and pharmacodynamics of drugs in vivo by upgrading in vitro data based on mathematical modelling

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If you have a question about this talk, please contact Florian Markowetz.

Experimental limitations as well as practical and ethical aspects set a barrier to our ability to analyse the pharmacokinetics and pharmacodynamics of drugs in vivo, in particular in human. In this talk, we will show how a physiologically- & mechanism-based modelling approach in combination with in vitro data can be used to analyse, understand and optimize drug pharmacokinetics and effect in vivo. We will illustrate how physiologically-based pharmacokinetic (PBPK) models can be used to predict drug pharmacokinetics prior to any in vivo experiment, how PBPK models, potentially evaluated and refined through first in vivo experiments, can then be reduced to simple compartment models representing essential PK characteristics of a drug, and how single cell experiments, integrated into such compartment models, offer the potential to elucidate and optimize drug action, in particular for therapeutic protein drugs.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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