Non invasive detection of tissue specific cell death via methylation patterns of circulating DNA

Add to your list(s) Download to your calendar using vCal

• Prof Yuval Dor from The Hebrew University-Hadassah Medical School
• Monday 19 November 2018, 16:30-17:30
• CRUK CI Lecture Theatre (Room 001).

If you have a question about this talk, please contact Anna.Toporska.

Cell-free circulating DNA (cfDNA), released from dying cells, is emerging as a diagnostic tool for monitoring cancer dynamics and graft failure. We developed a method of detecting tissue-specific cell death in humans, based on tissue-specific methylation patterns of DNA circulating in plasma. We interrogated tissue-specific methylome datasets to identify cell type-specific DNA methylation signatures, and established a method to detect these in mixed DNA samples and in cfDNA isolated from plasma. Using this new type of biomarker it is possible to detect the presence of cfDNA fragments derived from multiple tissues in healthy individuals and in pathologies including cancer, myocardial infarction, sepsis, neurodegeneration and more. In the long run we envision this approach opening a minimally-invasive window for monitoring and diagnosis of a broad spectrum of human pathologies, as well as better understanding of normal tissue dynamics.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

This talk is included in these lists:

• All CMS Events
• All Talks (aka the CURE list)
• Biology
• CCC talks for website
• CRUK CI Lecture Theatre (Room 001)
• CRUK CI Seminars
• CamBridgeSens
• Cambridge Centre for Data-Driven Discovery (C2D3)
• Cambridge talks
• Chris Davis' list
• Computational and Systems Biology
• Graduate-Seminars
• Interested Talks
• Liam
• Life Science Interface Seminars
• Life Sciences
• Life Sciences
• ME Seminar
• PMRFPS's
• School of Physical Sciences
• Seminars on Quantitative Biology @ CRUK Cambridge Institute
• Trust & Technology Initiative - interesting events
• bld31
• custom
• my_list
• ndk22's list
• ob366-ai4er
• other talks
• rp587
• se393's list
• sfm36

Note that ex-directory lists are not shown.