CCC talks for website

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structural basis of protein PARylation-dependent ubiquitination

User Rachel Klevit, University of Washington.

Thursday 24 April 2014, 16:15-18:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Engaging mechanisms of negative B cell selection to overcome drug-resistance in leukaemia

User Prof. Markus Müschen, UCSF.

Tuesday 22 April 2014, 15:00-16:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Francis Crick Lecture 2014: Prions Causing Neurodegeneration: A Unifying Etiology and the Quest for Therapeutics

User Stanley Prusiner, University of California San Francisco .

Friday 11 April 2014, 15:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

What can NMR tell us about how a virus enters its host cell?

User Ad Bax, NIH.

Thursday 10 April 2014, 11:00-12:00

House CRUK CI Lecture Theatre.

Postponed to 22 May Drug discovery

This talk has been postponed until 22 May

User Grahame McKenzie, MRC Cancer Unit.

Thursday 10 April 2014, 09:30-10:30

House CRUK CI Lecture Theatre.

Centrosome changes in cancer – causes and consequences

CRUK CI guest seminar

User Monica Bettencourt Dias, Instituto Gulbenkian de Ciência.

Wednesday 09 April 2014, 11:00-12:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Targeting bioenergetics in hypoxic and rapidly growing tumours

Hutchison/MRC Research Centre Seminar

User Dr Jacques Pouysseggur, Institute of Research on Cancer and Ageing (IRCAN), Nice, France.

Tuesday 08 April 2014, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Variations in genetic and phenotypic diversity during breast cancer progression.

User Vanessa Almendro (Harvard University).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 07 April 2014, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Neuroendocrine regulation of the bone marrow stem-cell niche

User Simón Méndez-Ferrer, CNIC, Madrid, Spain.

Friday 04 April 2014, 16:00-17:00

House CRUK CI Lecture Theatre.

Postponed to 19 June Epidemiology

Postponed to 19 June

User Paul Pharoah, Department of Public Health and Primary Care.

Thursday 03 April 2014, 09:30-10:30

House CRI Lecture Theatre, Cambridge Research Institute.

“Personalized Medicine in Oncology: The Dutch experience”

Host: Dr Richard Baird

User Professor Jaap Verweij, Erasmus MC Cancer Institute, Weytemaweg 80, 3105 CN Rotterdam, The Netherlands.

Tuesday 01 April 2014, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Single molecule approaches for studying gene expression in intact mammalian tissues.

User Shalev Itzkovitz (Weizmann Institute).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 31 March 2014, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Building proteins de novo: better, faster, fitter

User Dek Woolfson, University of Bristol.

Thursday 27 March 2014, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

John Kendrew Lecture 2014: Birth and Future of Multi-Scale Modeling of Macromolecules

User Michael Levitt, Standford Unversity.

Tuesday 25 March 2014, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Generating neuronal diversity: stochastic or deterministic choices

User Claude Desplan, Department of Biology, New York University, USA.

Tuesday 25 March 2014, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

microRNAs, circular RNAs, and micropeptides

User Professor Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine, Berlin.

Monday 24 March 2014, 15:00-16:15

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Heterogeneity of hematopoietic stem and progenitor cell populations: implications for ageing and regeneration

User Claus Nerlov, University of Oxford.

Friday 21 March 2014, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Clinical Systems Medicine in Acute Myeloid Leukemia and Beyond

User Olli Kallioniemi, Institute for Molecular Medicine Finland.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 20 March 2014, 13:00-14:00

In vivo models

User Suzanne Turner, Department of Pathology.

Thursday 20 March 2014, 09:30-10:30

House Cancer Research UK Cambridge Research Institute, Room 215.

CANCELLED The role of EGFR family receptor signaling-induced NF-kB activation in human breast cancer

User Debajit Biswas, Dana-Farber Cancer Institute and Harvard Medical School.

Wednesday 19 March 2014, 15:00-16:00

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Targeted Cancer Therapy: Accomplishments and Challenges

User John Mendelsohn, MD Anderson Cancer Center Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy.

Wednesday 19 March 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Of mice and men and Tasmanian devils; assembling reference genomes from single cells.

User Dr Mark Hills, Terry Fox Lab, Vancouver, Canada.

Friday 14 March 2014, 11:00-12:00

Genomic technologies

User Jason Carroll, Cancer Research UK Cambridge Institute.

Thursday 13 March 2014, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Origins and consequences of (epi)genetic variation in Arabidopsis thaliana and its relatives

User Detlef Weigel, Max Planck Institute for Developmental Biology, Tübingen, Germany.

Tuesday 11 March 2014, 11:00-12:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Notch and Wnt Signaling: From Hematopoeitic Stem Cells to Leukemia

User Anna Bigas. Cancer and Stem Cells Research Group. Institut Hospital del Mar d'Investigacions Mèdiques (IMIM).

Friday 07 March 2014, 13:00-14:00

Solid vs. non-solid tumours

Please note change of room, we will meet external attendees in reception and accompany them to the seminar room.

User Brian Huntly, Department of Haematology.

House CRUK CI Room 215.

Thursday 06 March 2014, 09:30-10:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Cell death and autophagy in response to inhibition of glycolysis

Hutchison/MRC Research Centre Seminar

User Dr Cristina Muñoz Pinedo, IDIBELL, Barcelona, Spain.

Tuesday 04 March 2014, 12:00-13:00

Molecular DNA Devices in Living Systems

User Dr Yamuna Krishnan, National Centre for Biological Sciences, TIFR, Bangalore, India.

Thursday 27 February 2014, 15:00-16:00

Computational biology

Please note change of room, we will meet external attendees in reception and accompany them to the seminar room.

User Florian Markowetz, Cancer Research UK Cambridge Institute.

House CRUK CI Room 215.

Thursday 27 February 2014, 09:30-10:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Type VI Secretion System: structure, function and dynamics of a multicomponent nanomachine that is evolutionarily related to a contractile phage tail

User Marek Basler, University of Basel.

Wednesday 26 February 2014, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Shedding light on cytoskeletal mRNA transport in vivo and in vitro

User Simon Bullock, MRC-LMB, Cambridge.

Tuesday 25 February 2014, 13:00-14:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

The Resistant Cancer Cell Line (RCCL) collection – cancer cell lines with acquired drug resistance as a pre-clinical and basic science model

User Martin Michaelis (University of Kent).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 17 February 2014, 16:00-17:00

Transcriptional regulation and techniques

Please note this talk is on a Wednesday

User Duncan Odom, Cancer Research UK Cambridge Institute.

Wednesday 12 February 2014, 09:30-10:30

House CRI Lecture Theatre, Cambridge Research Institute.

“What can we do to accelerate the discovery of new medicines for patients?”

Host: Dr Bristi Basu

User Professor Chas Bountra, Head of Structural Genomics Consortium, University of Oxford, Nuffield Dept of Clinical Medicine .

Tuesday 11 February 2014, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Mechanisms of centriole assembly

User Pierre Gönczy, EPFL, Lausanne, Switzerland.

Tuesday 11 February 2014, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Lighting up RNA Interactions in Living Cells

User David Tollervey, WTCCB, University of Edinburgh.

Monday 10 February 2014, 14:00-15:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

4D tracking of haematopoietic stem and progenitor cells in their bone marrow microenvironment

User Dr Cristina Lo Celso, Imperial College London.

Friday 07 February 2014, 16:00-17:00

Circulating DNA and diagnostics

User Nitzan Rosenfeld, Cancer Research UK Cambridge Institute.

Thursday 06 February 2014, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

The dinucleotide CpG as a genomic signalling module

User Adrian Bird, Wellcome Trust Centre for Cell Biology, University of Edinburgh, UK.

Tuesday 04 February 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Translating Tumour Metabolism into New Diagnostics and Novel Anti-Cancer Therapeutics

Hutchison/MRC Research Centre Seminar

User Professor Michael Lisanti, Director of the Breakthrough Breast Cancer Research Unit, University of Manchester.

Tuesday 04 February 2014, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Using time-resolved genetic data to study the evolution of drug resistance.

User Ville Mustonen (Sanger Institute).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 03 February 2014, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tube formation during C. elegans vulval development: Linking cell fate with morphogenesis

User Alex Hajnal, Institute of Molecular Life Sciences, University of Zurich, Switzerland.

Tuesday 28 January 2014, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Cell shape and morphogenesis: sub cellular and supra-cellular mechanisms

The Anne McLaren Lecture

User Maria Leptin, EMBO, Heidelberg, Germany.

Tuesday 28 January 2014, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Profiling the Subclonal Copy Number Architecture from Whole Genome Sequencing of Heterogeneous Tumours

User Gavin Ha, BC Cancer Research Centre.

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 27 January 2014, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Feldberg Prize Lecture: The mitochondrial machinery for transport and assembly of proteins

User Klaus Pfanner, University of Freiburg.

Thursday 23 January 2014, 16:15-18:00

Genetic instability - observation and concepts

User Paul Edwards, Department of Pathology.

Thursday 23 January 2014, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Structure, function and mechanisms of dynamin-superfamily proteins

User Oliver Daumke, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.

Tuesday 21 January 2014, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Stem cell dynamics during development, homeostasis and cancer

User Cédric Blanpain, WELBIO, Interdisciplinary Research Institute (IRIBHM), Université Libre de Bruxelles, Belgium.

Tuesday 21 January 2014, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Systems biology of stem cell fate

User Ben MacArthur (University of Southampton).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 20 January 2014, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

NextGen Research: Enabling distributed teams of experts and the engaged public to solve complex biomedical problems

User Stephen Friend, Sage Bionetworks, Seattle.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 16 January 2014, 13:00-14:00

Senescence, cell death and apoptosis

User Masashi Narita, Cancer Research UK Cambridge Institute.

Thursday 16 January 2014, 09:30-10:30

House CRI Lecture Theatre, Cambridge Research Institute.

Personalized medicine initiative at Gustave Roussy

Host: Dr Richard Baird

User Professor Jean-Charles SORIA - Chef de Service, Professor of Medicine and Medical Oncology, Paris University XI and cancer specialist at Institut Gustave, Roussy..

Tuesday 14 January 2014, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Systematic cell biology - Moving beyond text-book schemes

User Maya Schuldiner, The Weizmann Insitute of Science.

Thursday 09 January 2014, 14:00-15:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology

User Bengt Hallberg (Umea University, Sweden).

Tuesday 07 January 2014, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Chasing metabolic alterations in cancer

Hutchison/MRC Research Centre Seminar

User Dr Arkaitz Carracedo, CIC bioGUNE, (Center for Cooperative Research in Biosciences), Derio, Spain.

Tuesday 07 January 2014, 12:00-13:00

House CRI Lecture Theatre, Cambridge Research Institute.

CANCELLED

Host: Dr Richard Baird

User Prof Josep Tabernero, Head, Medical Oncology Department, Vall d' Hebron University Hospital, Barcelona, Spain.

Tuesday 17 December 2013, 12:00-13:00

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Detecting low-concentration compounds with water sensitivity and spectroscopic specificity using CEST-MRI

User Peter van Zijl, Johns Hopkins University and Kennedy Krieger Institute.

Friday 13 December 2013, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

GPCRs: From thermostabilisation to X-ray structures and Drug discovery

User Fiona Marshall, Heptares Therapeutics.

Thursday 12 December 2013, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Harnessing Genetic Dependencies in Cancer Therapy

User Alan Ashworth, The Institute of Cancer Research, London.

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Thursday 12 December 2013, 13:00-14:00

Metastasis

User Gill Murphy, Cancer Research UK Cambridge Institute.

Thursday 12 December 2013, 09:30-10:30

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Comprehensive transcriptome and epigenome sequencing of hypoxic breast cancer reveals non-coding RNAs associated with clinicopathological features

User Ioannis (Jiannis) Ragoussis, McGill University, Canada and Genome Quebec Innovation Centre.

Monday 09 December 2013, 13:00-14:00

Competition between adaptor protein and phospholipase regulates metastatic outcome

User Prof John E. Ladbury, Edward Rotan Distinguished Professor in Cancer Research & Director of the Center for Biomolecular Structure and Function, MD Anderson Cancer Center.

Friday 06 December 2013, 15:00-16:00

Tumour metabolism

User Christian Frezza, MRC Cancer Unit.

Thursday 05 December 2013, 09:30-10:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The autophagy signaling network in the coordination of a cell's response

Hutchison/MRC Research Centre Seminar

User Prof Francesco Cecconi, University of Tor Vergata, Italy .

Tuesday 03 December 2013, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Bending the not so simple mind of the fruit fly

User Scott Waddell, Centre for Neural Circuits and Behaviour, University of Oxford.

Tuesday 03 December 2013, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Incorporating Prior Biological Knowledge into Genetic Association Studies

User David V. Conti (USC).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 02 December 2013, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Hallmarks of Cancer: Applications to Cancer Medicine?

User Douglas Hanahan, Swiss Institute for Experimental Cancer Research.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 28 November 2013, 13:00-14:00

House CRI Lecture Theatre, Cambridge Research Institute.

"The Cambridge Breast Cancer Programme"

Host: Dr Richard Baird

User Prof Carlos Caldas, CRUK Cambridge Research Institute.

Tuesday 26 November 2013, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Cancer Epigenetics: Appreciating the beauty and complexity of a string of pearls

User Mark Dawson, University of Cambridge.

Friday 22 November 2013, 16:00-17:00

Stem cells and cancer

User Phil Jones, MRC Cancer Unit.

Thursday 21 November 2013, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Growth and size regulation in development and disease

User Tian Xu, HHMI/Yale University, USA.

Tuesday 19 November 2013, 11:00-12:00

Introduction to cancer in Cambridge (BP) followed by Cell cycle and checkpoints (AP)

User Bruce Ponder and Anna Philpott, Department of Oncology.

Thursday 14 November 2013, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Towards an RNA structure of everything

User Kevin Weeks, Department of Chemistry, University of North Carolina, Chapel Hill.

Tuesday 12 November 2013, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Haematopoietic Stem Cells

User Prof. Connie Eaves, Terry Fox Laboratory, Vancouver.

Tuesday 12 November 2013, 12:30-13:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Measuring within-tumour diversity as a universal biomarker for cancer prognosis

User Trevor Graham (Barts Cancer Institute, Queen Mary Univ London).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 11 November 2013, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Emerging therapeutic strategies for treating the first molecular disease

User Prof. James Douglas Engel, University of Michigan Medical School, USA.

Friday 08 November 2013, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Brain Power: Where does it come from and how is it used?

User Professor David Attwell, University College London.

Thursday 07 November 2013, 17:00-18:00

Transcription

User Jason Carroll, Cancer Research UK Cambridge Institute.

Thursday 07 November 2013, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Regulation of pre-mRNA splicing fidelity by the Nineteen Complex

User Raymond O'keefe, Faculty of Life Sciences, University of Manchester.

Tuesday 05 November 2013, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Self-regulatory mechanism of multicellular systems: tissue self-organization and scaling

User Yoshiki Sasai, RIKEN Center for Developmental Biology, Kobe, Japan.

Tuesday 05 November 2013, 11:00-12:00

MRC Cancer Unit Annual Lecture

The p53 pathway: 21 years of the "guardian of the genome"

Refreshments will be available after this talk outside the lecture theatre

User Prof Sir David Lane, Chief Scientist, A*STAR, Singapore.

House Max Perutz Lecture Theatre, MRC Laboratory of Molecular Biology.

Monday 04 November 2013, 16:00-17:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

John Kendrew Lecture 2013: Noncoding RNAs: with a viral twist

User Joan Steitz, Yale University.

Friday 01 November 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Embracing Complexity: A Drosophila Approach To Cancer Therapeutics

User Ross Cagan, Mt. Sinai School of Medicine.

Thursday 31 October 2013, 16:15-18:00

Oncogenes and tumour suppressors (signalling and pathways)

User Masashi Narita, Cancer Research UK Cambridge Institute.

Thursday 31 October 2013, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

The biochemistry & genetics of bacterial predation by Bdellovibrio bacteriovorus

User Liz Sockett, School of Biology, University of Nottingham.

Tuesday 29 October 2013, 13:00-14:00

House CRI Lecture Theatre, Cambridge Research Institute.

CANCELLED - Scottish Collaboration On Translational Research into Renal Cell Cancer, developing a systems medicine approach to personalised treatment

User Mr Grant Stewart, Department of Urology and Edinburgh Urological Cancer Group,Western General Hospital. Edinburgh.

Tuesday 29 October 2013, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Quantitative Analysis of Transcriptomes and Proteomes in Proliferating and Quiescent Cells

User Jürg Bähler, Department of Genetics, Evolution & Environment, UCL.

Tuesday 22 October 2013, 13:00-14:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Analysis of a large cancer gene screen in myelodysplastic syndromes

User Moritz Gerstung (Sanger).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 21 October 2013, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Bone marrow environment and platelet production

User Assoc. Prof. Alessandra Balduini, University of Pavia Italy, and Tufts University USA.

Friday 18 October 2013, 16:00-17:00

Development

User Anna Philpott, Department of Oncology.

Thursday 17 October 2013, 09:30-10:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Mutations in Epigenetic Modifiers in Myeloid Malignancies

User Dr Ross Levine, Memorial Sloan-Kettering Cancer Center, New York.

Tuesday 15 October 2013, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Chromatin and its Impact on Gene Expression and Cellular Memory

Please note that this talk is on a Tuesday

User Danny Reinberg, Howard Hughes Medical Institute, NYU School of Medicine.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Tuesday 15 October 2013, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Thrombospondins, Matrix and the Emerging Role of Fascin-1 in Carcinoma Metastasis

User Josephine C. Adams, School of Biochemistry, Bristol.

Tuesday 15 October 2013, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Mechanisms of cellular programming and reprogramming

User Ken Zaret, University of Pennsylvania, USA.

Tuesday 15 October 2013, 11:45-12:45

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Can structural studies of intact viruses really be useful in the search for better vaccines and antivirals?

User David Stuart, University of Oxford.

Thursday 10 October 2013, 16:15-18:00

House CRI Lecture Theatre, Cambridge Research Institute.

Spotlight on Cambridge Clinical Trials; Presentations from the American Society of Oncology (ASCO) Annual Meeting 2013

Host: Dr Simon Pacey

User Prof Tim Eisen, Dr Hugo Ford, Dr Pippa Corrie & Dr Kate Fife.

Tuesday 08 October 2013, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Forward genetic screening using patient CML cells identifies IKAROS as a myeloid tumour suppressor

User Dr Philip Beer, Terry Fox Laboratory, Vancouver.

Monday 07 October 2013, 17:00-18:00

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Tumor hypoxia: developing prognostic biomarkers to predict therapeutic outcome

User Ralph P. Mason, The University of Texas Southwestern Medical Center.

Friday 04 October 2013, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Conformational Conversion in Amyloid Assembly

User Sheena Radford, University of Leeds.

Thursday 03 October 2013, 16:15-18:00

House CRI Lecture Theatre, Cambridge Research Institute.

Target-Based Approach in Early-Phase Clinical Trials in Cancer

Host: Dr Richard Baird

User Filip Janku, Investigational Cancer Therapeutics, (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston.

Tuesday 01 October 2013, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Milstein Lecture 2013: Sorting out protein traffic: Ubiquitin-mediated endocytosis and a membrane protien’s final ESCRT

User Scott Emr, Cornell University.

Thursday 26 September 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Innate Immune Sensing and Signaling of Cytosolic DNA and RNA

User Zhijan 'James' Chen, University of Texas Southwestern Medical Center.

Tuesday 24 September 2013, 16:15-18:00

CANCELLED

User Professor Charles Swanton, CRUK & UCL Trials Centre, UCL.

Tuesday 24 September 2013, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Molecular and cellular basis of disease initiation in myeloproliferative neoplasms

User Prof. Radek Skoda, Head of the Department of Biomedicine, University Hospital, Basel.

Friday 20 September 2013, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Inflammation and Cancer: Reprogramming the immune microenvironment as an anti-cancer therapeutic strategy

User Lisa M. Coussens. Department of Cell & Developmental Biology, Knight Cancer Institute, Oregon Health & Sciences University.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 19 September 2013, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Look Beyond the Target: How Lessons from Chronic Myeloid Leukaemia Can Improve Cancer Targeted Therapies

User Assoc. Prof. Sin Tiong Ong, Duke-NUS Graduate Medical School Singapore & Duke University Medical Center.

Wednesday 18 September 2013, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Colon CSCs are sensitized by HDACinhibitors in a FOXO-dependent fashion

User Jan Paul Medema (Amsterdam Medical Center).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 16 September 2013, 16:00-17:00

Advances in non-surgical treatment for cervix cancer

User Dr Li Tee Tan, Addenbrooke's .

Tuesday 10 September 2013, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Long-distance organelle transport in the neuron: mechanisms of motor engagement and motor coordination

User Erika Holzbaur, University of Pennyslvania.

Thursday 05 September 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The Evolutionary 'Design' of Proteins

User Rama Ranganathan, UT Southwestern Medical Centre.

Wednesday 04 September 2013, 11:00-12:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Insights for the role of tumour-related inflammation and stem cells in Drosophila

Hutchison/MRC Research Centre Seminar

User Dr Marcos Vidal, Beatson Institute, Glasgow .

Tuesday 03 September 2013, 12:00-13:00

Asian Cancer Genomics and its Clinical Implications

User Professor Bin Tean Teh, National Cancer Centre Singapore (NCCS)-VARI Laboratory .

Friday 23 August 2013, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Watching Individual Proteins Working on Single Molecules of DNA: from Biophysics to Cancer

User Steve Kowalczykowski, University of California.

Friday 09 August 2013, 16:15-18:00

Hutchison/MRC Research Centre Seminars

Regulation of p53-dependent gene expression in vivo

User Prof James J. Manfredi, Department of Oncological Sciences, Mount Sinai School of Medicine, USA.

House L1 Meeting Rooms, Hutchison/MRC Research Centre, Addenbrooke's Campus.

Tuesday 06 August 2013, 15:00-16:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Biological insights from cryo-EM studies of complex macromolecular assemblies in transcription initiation and microtubule dynamics

User Eva Nogales, HHMI University of California Berkely.

Wednesday 24 July 2013, 16:15-18:00

Hutchison/MRC Research Centre Seminars

CD66+/Notch high cells in human cervical tumours: linking papillomavirus life cycle to cancer progression

User Professor Sudhir Krishna, National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.

Cancer Research UK Cambridge Institute Seminars in Cancer

Thursday 18 July 2013, 15:00-16:00

HER2 and EGFR: Signalling mechanisms and next generation cancer therapies

User Yosef Yarden, Weizmann Institute of Science, Israel.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 18 July 2013, 13:00-14:00

House CRI Lecture Theatre, Cambridge Research Institute.

Risk and uncertainty in radiotherapy. Why I am the weakest link?

User Dr Tom Roques, Lead of Head and Neck Cancer Multidisciplinary Team, Norfolk and Norwich Hospital.

Tuesday 16 July 2013, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Platinum Genomes

User Michael Eberle (Illumina).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Thursday 04 July 2013, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Genetic modifiers and microenvironmental control of tumor invasiveness

Hutchison/MRC Research Centre Seminar- Please note unusual time and 1:00pm start

User Prof Douglas Hanahan, EPFL, Switzerland .

Tuesday 02 July 2013, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The impact of systemic inflammation on the brain in health and disease

User Hugh Perry, University of Southampton.

Thursday 27 June 2013, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer

Note unusual day and time!

User Stefan Wiemann (DKFZ Heidelberg).

House Cancer Research UK Cambridge Institute, Room 009.

Tuesday 25 June 2013, 17:00-18:00

House CRI Lecture Theatre, Cambridge Research Institute.

"Image guidance – benefits and risks"

User Professor Marcel van Herk, Imaging Physicist, Project Leader, The Netherlands Cancer Institute.

Tuesday 25 June 2013, 12:00-13:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Duplicating the Human genome: The Origin Recognition Complex et al

User Bruce Stillman, FAA, FRS - Cold Spring Harbour Laboratory, New York.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 20 June 2013, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Intrinsic biophysical diversity and connectivity of neuronal circuits

User Troy Margrie, NIMR.

Tuesday 11 June 2013, 17:00-18:00

Economics of Cancer Medicines

User Professor Richard Sullivan, Guy's Hospital, London.

Tuesday 11 June 2013, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Direct Selection for Antibodies that Control Cell Fates from Intracellular Combinatorial Antibody Libraries

User Professor Richard Lerner, The Scripps Research Institute, USA.

Wednesday 05 June 2013, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Control of cytokinesis and the dark side of actomyosin forces

Hutchison/MRC Research Centre Seminar

User Dr Mark Petronczki, London Research Institute.

Tuesday 04 June 2013, 12:00-13:00

Stem cell dynamics in the pancreas

User Prof Christopher Heeschen, CNIO, Spain.

Thursday 30 May 2013, 14:30-15:30

"Renal Cancer and Oxygen Sensing"

User Prof Patrick Maxwell, Regius Professor of Physic, University of Cambridge.

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Tuesday 28 May 2013, 12:00-13:00

Petri nets as semi-quantitative modeling method to explore systems behavior of disease-related pathways

User Ina Koch (Frankfurt University).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 20 May 2013, 16:00-17:00

House Cancer Research UK Cambridge Institute, Lecture Theatre.

SMARTer cDNA Synthesis for Illumina Sequencing and iDimerize Inducible Dimerization Systems

User Syed Abedi, Takara-Clontech.

Thursday 16 May 2013, 10:30-12:00

‘CLL – from chemotherapy to targeted kinase inhibition’

Buffet Lunch will be provided by courtesy of Chugai Pharma UK Ltd.

User Dr George Follows, Consultant Haematologist, Addenbrooke's .

Tuesday 14 May 2013, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Cytoskeletal Control of Leukocyte Chemotaxis

User Michael Sixt, IST Austria.

Monday 13 May 2013, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Genome-wide association studies: Lessons from studying a large clinical cohort

User Sven Bergmann (Lausanne).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 13 May 2013, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Macrophages Into Tumor Hypoxic Areas: Should I Stay Or Should I Go?

Hutchison/MRC Research Centre Seminar

User Dr Massimiliano Mazzone, VIB Vesalius Research Center, Belgium.

Tuesday 07 May 2013, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Polycomb-mediated selfrenewal of young (and aged?) hematopoietic stem cells

User Gerald de Haan, Scientific Co-Director, European Research Institute for the Biology of Ageing.

Friday 03 May 2013, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Selective autophagy: when being picky pays of

User Ana-Maria Cuervo, Albert Einstein College of Medicine .

Thursday 02 May 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Max Perutz Lecture: Five ways that viruses use to enter the animal cell

User Professor Ari Helenius, ETH Zurich, Switzerland.

Tuesday 30 April 2013, 14:30-15:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Mapping tumor heterogeneity and developmental trajectories using 40 markers at single cell resolution:

Room change: 215 instead of lecture theatre (outside guests will need visitor ID)

User Dana Pe'er (Columbia University, NYC).

House Cancer Research UK Cambridge Research Institute, Room 215.

Monday 29 April 2013, 16:00-17:00

House CRI Lecture Theatre, Cambridge Research Institute.

“The identification of patients who benefit from targeted therapy in renal cancer”

(The lunch will be provided by courtesy of Pfizer)

User Professor Thomas Powles, Barts Cancer Institute, Queen Mary University of London.

Tuesday 23 April 2013, 12:00-13:00

Cancer Research UK Cambridge Institute Seminars in Cancer

The impact of cohesin on the regulation of gene expression and the organization of chromatin

User Matthias Merkenschlager, Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London.

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Thursday 18 April 2013, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Machinery for making coated vesicles

User Margaret Scott Robinson, CIMR.

Tuesday 16 April 2013, 16:15-18:00

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Standardising tumour tissue dissociation to increase the reliability and reproducibility of downstream analysis

User Dawn Farrar, Miltenyi Biotec.

Wednesday 10 April 2013, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The genetics of individuals: why would a mutation kill me, but not you?

User Ben Lehner, CRG Barcelona.

Tuesday 09 April 2013, 15:00-16:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Impact of cancer- and stroma-cell-derived lysosomal proteases on cancer invasion and metastasis

User Thomas Reinheckel, University of Freiburg.

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Thursday 28 March 2013, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The mammalian circadian timing system: how the brain communicates with the periphery

User Ueli Schibler, University of Geneva.

Wednesday 27 March 2013, 12:00-13:00

Computational biology

User Florian Markowetz, Cancer Research UK Cambridge Research Institute.

Thursday 21 March 2013, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Spatial and temporal regulation of the DNA damage response

User Jiri Lukas, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark.

Tuesday 19 March 2013, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Inferring causal mediators from omics data in the context of genetic and environmental variations

User Oliver Stegle (EBI).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 18 March 2013, 16:00-17:00

House CRUK Cambridge Institute Room 215.

New tools for NGS libraries: Long-Span, Mate-Pair Scaffolding and Methods for Faster Library Creation

Places are limited, please e-mail saphsa.codling@cruk.cam.ac.uk if you want to attend

User David Mead, Founder and Chief Executive Officer of Lucigen .

Wednesday 13 March 2013, 12:30-13:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Drugging the cancer genome

User Paul Workman, Institute of Cancer Research, Sutton, Surrey.

Tuesday 12 March 2013, 13:00-14:00

CANCELLED

User Dr Fiona Blackhall, Manchester University, Manchester Cancer Research Centre Lung Group Lead.

Tuesday 12 March 2013, 12:00-13:00

Deciphering mechanisms regulating cell growth and homeostasis with genome-scale in silico models

User Dr Nathan Lewis, Harvard Medical School.

Monday 11 March 2013, 14:30-15:30

Epigenetic cancer conspirators: DNA methylation, non-coding RNA and chromatin loops

This is an open seminar, all are welcome to attend

User Adele Murrell, CRUK Cambridge Institute.

Thursday 07 March 2013, 09:45-10:45

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Mechanisms of Wnt signal transduction

User Christof Niehrs, Institute of Molecular Biology (IMB), Mainz, Germany.

Tuesday 05 March 2013, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

The logic and variation in genomic regulatory networks

User Mikhail Spivakov (Babraham Institute).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 04 March 2013, 16:00-17:00

Deconstructing Metastasis - Epigenetic Expansion of the VHL-HIF Signal Output Drives Renal Cancer Progression

User Dr Sakari Vanharanta, Cancer Biology and Genetics Programme, Memorial Sloan-Kettering Cancer Centre, USA.

Friday 01 March 2013, 14:30-15:30

Exploiting cancer stem cells for the identification of mediators involved in brain tumorigenesis

User Dr Rossella Galli, Stem Cell Biology Unit, San Raffaele Scientific Institute, Milan, Italy.

Thursday 28 February 2013, 14:30-15:30

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Expansion and spread of oncogenic K-ras mutant stem cells throughout the intestinal epithelium

User Hugo Snippert (Molecular Cancer Research, University Medical Center, Utrecht).

Tuesday 26 February 2013, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Title to be confirmed

CANCELLED

User Hans Wolf-Watz, University of Umea, Sweden.

Tuesday 26 February 2013, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Controlling gene expression fluctuations during development

User Alexander van Oudenaarden, Hubrecht Institute-KNAW & University Medical Center Utrecht, Netherlands.

Tuesday 26 February 2013, 11:00-12:00

The NCI anticancer drug screen: Cancer through the lens of 60 cell lines

User Dr Alexei Vazquez, Department of Radiation Oncology and Cancer Center for Systems Biology, CINJ/UMDNJ-Robert Wood Johnson Medical School, USA.

Cancer Research UK Cambridge Institute Seminars in Cancer

Friday 22 February 2013, 14:30-15:30

Molecular dissection and targeting of epigenetic machinery in AML stem cells

User Eric So, Department of Haematological Medicine, King's College London.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 21 February 2013, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Arrivals and departures: how Arf family G proteins organise membrane traffic at the Golgi

User Sean Munro, MRC-LMB, Cambridge.

Tuesday 19 February 2013, 13:00-14:00

Challenges in Implementing Personalized Cancer Medicine: the IGR experience

User Professor Alexander Eggermont, Director General, Institut de Cancérologie Gustave Roussy, France.

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Tuesday 19 February 2013, 12:00-13:00

Metabolic regulation of the stress response and the cancer cell's Warburg effect

User Markus Ralser (University of Cambridge, Dept of Biochemistry).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 18 February 2013, 16:00-17:00

Mitochondrial oxidative signaling in T cell activation: role for Warburg effect and a new ADP-dependent glucokinase

User Marcin Kaminski, German Cancer Research Center (DKFZ), Heidelberg.

Thursday 14 February 2013, 14:30-15:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

The CRISPR system for prokaryotic antiviral immunity

User Malcolm White, St. Andrews University, UK.

Tuesday 12 February 2013, 13:00-14:00

What is the epigenetic landscape of the vertebrate kinetochore?

User Prof William Earnshaw, Wellcome Trust Centre for Cell Biology, University of Edinburgh.

Wednesday 06 February 2013, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Ubiquitin signalling in immunity and inflammation - Working on the chain gang

User Katrin Rittinger, National Institute for Medical Research, Mill Hill.

Tuesday 05 February 2013, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Telomeres and the challenges to chromosome integrity

Hutchison/MRC Research Centre Seminar

User Dr Julie Cooper, London Research Institute.

Tuesday 05 February 2013, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Immune regulation of vertebrate regeneration

User Nadia Rosenthal, National Heart and Lung Institute, Imperial College London; Australian Regenerative Medicine Institute, Monash University; EMBL Australia.

Tuesday 05 February 2013, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Evolution of cellular networks: from interactions to phenotypes

User Pedro Beltrao (EMBL-EBI).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 04 February 2013, 16:00-17:00

Proteinases and Cancer

User Gill Murphy, CRUK Cambridge Research Institute.

Thursday 31 January 2013, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

The genetics of individuals: why would a mutation kill me, but not you?

User Ben Lehner, Centre for Genomic Regulation, Barcelona, Spain.

Tuesday 29 January 2013, 13:00-14:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Circulating tumour DNA as a biomarker of genetics alterations in cancer

User Florent Mouliere (IRCM U896 Inserm, Montpellier, France).

House Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 28 January 2013, 16:00-17:00

Stem cells and cancer

User John Stingl, Cambridge Research Institute.

Thursday 24 January 2013, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

New insights into old parasites - Plasmodium malariae, P. ovale spp and the mysterious process of host transition.

User Colin Sutherland, London School of of Hygiene and Tropical Medicine.

Tuesday 22 January 2013, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Reprogramming and cellular dominance

User Amanda Fisher, Imperial College, London.

Tuesday 22 January 2013, 11:00-12:00

Estrogen receptor and its role in transcription and breast cancer

User Jason Carroll, CRI.

Thursday 17 January 2013, 09:30-10:30

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Fundamentals and Applications of Mass Cytometry, using CyTOF

User Jane Limer, DVS Sciences.

Wednesday 16 January 2013, 11:00-12:00

Dual role of BubR1 acetylation: Lessons from the acetylation-deficient mice

User Dr Hyunsook Lee, Seoul National University.

Monday 14 January 2013, 11:30-12:30

Microtubules: boring polymers or the Achilles heel of cancer?

User Fanni Gergely, CRUK Cambridge Research Institute.

Cancer Research UK Cambridge Institute Imaging Seminars

Thursday 13 December 2012, 09:30-10:30

Multiparametric MRI of the vasculature: applications to therapy monitoring of gliomas

User Chantal Remy, Grenoble Institute of Neurosciences, France.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Wednesday 12 December 2012, 16:30-17:30

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Molecular pathology: building the backbone of translational research and personalised medicine

User Manuel Salto-Tellez, Queens's University Belfast.

Tuesday 11 December 2012, 10:00-11:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Localisation-based feedback controls during mitosis and the maintenance of chromosomal stability

Hutchison/MRC Research Centre Seminar

User Dr Adrian Saurin, University Medical Center Utrecht, The Netherlands.

Tuesday 04 December 2012, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Unlocking the secrets of scarless wound healing and appendage regeneration

User Enrique Amaya, University of Manchester.

Tuesday 04 December 2012, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Assembly and Dynamics of Uber Complex RNPs

User Melissa Moore, University of Massachusetts Medical School.

Monday 03 December 2012, 16:15-18:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Epigenetic reprogramming in mammalian development

User Wolf Reik.

Friday 30 November 2012, 16:00-17:00

Talk postponed Introduction to statistics

**Talk postponed** Will be rescheduled next year

User Sarah Vowler, CRI.

Thursday 29 November 2012, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Genetic dissection of the ß-barrel assembly machine in Gram-negative bacteria

User Thomas J. Silhavy, Princeton University .

Tuesday 27 November 2012, 13:00-14:00

Cellular responses to DNA damage: translating molecular insights towards new cancer therapies

User Prof Steve Jackson, Head of Cancer Research UK Laboratories The Gurdon Institute, Cambridge.

Tuesday 27 November 2012, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

How the INO80 and PBAF chromatin remodelling complexes function to maintain genome stability

User Jessica Downs, MRC Genome Damage and Stability Centre, University of Sussex, Brighton.

Tuesday 20 November 2012, 13:00-14:00

House CRI Lecture Theatre, Cambridge Research Institute.

Mechanisms of Estrogen Receptor Transcription in Breast Cancer

User Dr Jason Carroll, CRUK Cambridge Research Institute.

Tuesday 20 November 2012, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Gene punctuation in eukaryotes: roles of R-loops, gene loops and co-transcriptional cleavage in controlling transcription

User Nick Proudfoot, University of Oxford.

Tuesday 20 November 2012, 11:00-12:00

Cancer Research UK Cambridge Institute Seminars in Cancer

PLEASE NOTE THAT THIS TALK HAS BEEN CANCELLED

User Danny Reinberg.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 15 November 2012, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Synthetic genetic polymers

User Philipp Holliger, MRC LMB, Cambridge .

Tuesday 13 November 2012, 13:00-14:00

"Towards personalized medicine in Breast Cancer"

User Prof. Dr. Sabine C. Linn, medical oncologist Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

Tuesday 13 November 2012, 12:00-13:00

A systems view of the cancer cell: from missing genetic variability to combination therapy

User Andrea Califano, Columbia University.

Wednesday 07 November 2012, 10:30-11:30

A genomic Odyssey of predicting drug response: is Ulysses home yet?

User Dr Federico Innocenti, UNC Institute for Pharmacogenomics and Individualized Therapy.

Tuesday 06 November 2012, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Mining RNA-seq Data For Insights into Intron Splicing and Recycling

User Will Fairbrother, Department of Molecular and Cellular Biology, Brown University.

Tuesday 06 November 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Signalling Networks in Cell Proliferation and Fate Control

Hutchison/MRC Research Centre Seminar

User Professor Sibylle Mittnacht, UCL Cancer Institute.

Tuesday 06 November 2012, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Lipoproteins and signaling lipids in the Hedgehog pathway

User Suzanne Eaton, Max Planck Institute of Molecular Cell Biology & Genetics, Dresden.

Tuesday 06 November 2012, 11:00-12:00

Basics of the cell cycle

User Anna Philpott, Department of Oncology, MRC-Hutchison Research Centre.

Thursday 01 November 2012, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Drug Discovery for Neglected Diseases - Successes, Failures and Lessons Learned

User Alan Fairlamb, College of Life Sciences, University of Dundee.

Tuesday 30 October 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The Aging of Hematopoietic Stem Cells

User David Bryder, Lund University.

Tuesday 30 October 2012, 13:00-14:00

Overview of cancer theoretical framework

User Paul Edwards, Department of Pathology, MRC-Hutchison Research Centre.

House CRI Room 009.

Thursday 25 October 2012, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Enjoying the sun – Macromolecular machines involved in DNA damage detection and repair

User Nicolas Thoma, Friedrich Miescher Institute, Basel, Switzerland.

Tuesday 23 October 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Genome-wide mapping of DNA rearrangements in single cells using DNA template strand sequencing

User Peter Lansdorp, European Research Institute on the Biology of Ageing, University of Groningen.

Friday 19 October 2012, 16:00-17:00

Tumour natural history, structure and nomenclature (lecture/demonstration)

User Paul Edwards, Department of Pathology, MRC-Hutchison Research Centre.

Thursday 18 October 2012, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Endosymbiosis, genome mosaicism, and the evolution of photosynthetic eukaryotes

User Prof. John Archibald, Department of Biochemistry & Molecular Biology, Dalhousie University, Nova Scotia, Canada.

Tuesday 16 October 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tet proteins and methylcytosine oxidation

User Anjana Rao, La Jolla Institute for Allergy and Immunology.

Monday 15 October 2012, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Covert communication in insects

User Richard Benton, Center for Integrative Genomics, University of Lausanne.

Tuesday 09 October 2012, 11:00-12:00

Cancer Research UK Cambridge Institute Seminars in Cancer

The Ras pathway in cancer therapy

Note unusual day

User Frank McCormick, UCSF Helen Diller Family Comprehensive Cancer Center.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Wednesday 03 October 2012, 13:00-14:00

Mutant p53 Enhances Receptor Recycling to Promote Invasion and Metastasis

User Dr Patricia Muller, Beatson Institute, Glasgow.

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Monday 01 October 2012, 14:30-15:30

Network biology of cancer

User Andrea Califano (Columbia University, New York).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Friday 28 September 2012, 10:30-11:30

Glutamine Metabolism and mTOR Signaling in Cell Growth Regulation

User Dr Raul Duran, University of Basel, Switzerland.

Thursday 27 September 2012, 14:30-15:30

RNA Regulatory Networks Help Propagate the Effects of Genetic Alterations

User Dr Pavel Sumazin, Center for Computational Biology and Bioinformatics, Columbia University, USA.

Friday 21 September 2012, 14:30-15:30

Epigenetic Regulatory Complexes in Development and Cancer

User Dr Peter Mulligan, Harvard University.

Cancer Research UK Cambridge Institute Seminars in Cancer

Thursday 20 September 2012, 14:30-15:30

Challenges in Building a Genomic Prescribing System

User Mark J. Ratain, Director, Center for Personalized Therapeutics, University of Chicago.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 20 September 2012, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

New insights into the role of the chromatin associated factor ATRX

User Doug Higgs, MRC Molecular Haematology Unit, Oxford.

Monday 17 September 2012, 11:30-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Max Perutz Lecture 2012: Defective DNA strand break repair, genome instability and cancer

User Steve West, CRUK LRI - Clare Hall.

Thursday 13 September 2012, 16:15-18:00

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Functional heterogeneity in intestinal stem cells and cancer

User Doug Winton, Cancer Research UK Cambridge Research Institute.

Thursday 13 September 2012, 11:45-12:45

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Niche, signaling, and epigenetic regulation of stem cells

User Linheng Li, Stowers Institute for Medical Research.

Wednesday 12 September 2012, 13:00-14:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Lgr5 stem cells in self-renewal and cancer

Please note that this talk is on a Tuesday (joint seminar with the MRC-LMB)

User Hans Clevers, Hubrecht Institute, The Netherlands.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Tuesday 11 September 2012, 13:00-14:00

House Cambridge Research Institute.

Lgr5 Stem Cells in self-renewal and cancer

Joint lecture with CRI and MRC LMB

User Hans Clevers, Hubrecht Institute.

Tuesday 11 September 2012, 13:00-14:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

From protein networks to disease mechanisms

User Roded Sharan (Tel-Aviv University).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 10 September 2012, 16:00-17:00

'Circulating Tumour Cells: Biomarker Utility and Insights to Metastasis'

User Professor Caroline Dive, Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, Manchester.

Tuesday 14 August 2012, 12:00-13:00

The metabolism of hereditary renal cancer

User Dr Patrick Pollard, University of Oxford.

Wednesday 01 August 2012, 12:00-13:00

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

How mitotic spindles adapt to the presence/absence of centrosomes

User Hélder Maiato, Universidade do Porto, Portugal.

Thursday 19 July 2012, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

The role of telomeres and telomerase in stem cell biology, cancer and ageing

User Maria Blasco, CNIO, Madrid.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 19 July 2012, 13:00-14:00

Aggressive breast tumors show altered lipid metabolism

User Dr Mika Hilvo, VTT Technical Research Centre of Finland.

Wednesday 18 July 2012, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Normal and neoplastic stem cells

User Irving Weissman, Stanford School of Medicine.

Wednesday 11 July 2012, 16:15-18:00

Metaplasia and carcinogenesis in stratified epithelia: the role of chronic inflammation

User Dr Craig Nowell, EPFL, Switzerland.

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Tuesday 03 July 2012, 13:00-14:00

Variational Methods in 3+Dimensional Biomedical Imaging

User Martin Burger (Uni Münster).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 02 July 2012, 16:00-17:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

The life histories of 21 breast cancers

User Peter van Loo (Sanger Institute).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 25 June 2012, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Mechanisms for the Selective Degradation of Ubiquitinated Proteins by the 26S Proteasome

User Fred Goldberg, Harvard Medical School.

Friday 22 June 2012, 16:15-18:00

Understanding Response & Resistance Mechanisms to Targeted Therapy

Note unusual day and time

User Dr Keith Flaherty, Director of Developmental Therapeutics at Massachusetts General Hospital.

Cancer Research UK Cambridge Institute Seminars in Cancer

Thursday 21 June 2012, 16:00-17:00

Cellular Conversations that Control Cell Fate

User Thea Tlsty, University of California, San Francisco.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 21 June 2012, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Shedding light on Ubiquitin Modification in Cancer.

User Vishva Dixit, Genentech.

Tuesday 12 June 2012, 16:15-18:00

House CRI Lecture Theatre, Cambridge Research Institute.

Cancer-related inflammation

User Dr Thorsten Hagemann, Barts Cancer Institute, Queen Mary University of London.

Tuesday 12 June 2012, 12:00-13:00

House CRI Lecture Theatre, Cambridge Research Institute.

Pancreatic cancer: Genetic models to develop novel diagnostic and therapeutic strategies

User Dr Dieter Saur, The Technical University of Munich.

Tuesday 29 May 2012, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The structural and mechanistic basis for Rab cycling and targeting

User Roger Goody, MPI Dortmund.

Monday 21 May 2012, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Biological Image Analysis Made Easy

Note the unusual time: 11am not 4pm!

User Fred Hamprecht (Heidelberg).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 21 May 2012, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Milstein Lecture 2012: How do we sense microbes? From LPS, TNF, and the TLRs.

User Bruce Beutler, UT Southwestern Medical Centre.

Thursday 17 May 2012, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Common and rare variants in the sequence of the human genome that affect the risk of cancers and other diseases of man

User Kari Stefansson, deCODE Genetics, Iceland.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 17 May 2012, 13:00-14:00

"Strategies to enhance effectiveness of Radiotherapy in Pancreatic Cancer"

User Dr Thomas Brunner, Gray Institute for Radiation Oncology and Biology, Oxford.

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Tuesday 15 May 2012, 12:00-13:00

The evolution of mammalian tissue transcriptomes

User Henrik Kaessmann (Lausanne).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 14 May 2012, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Immune cell transdifferentiation

User Thomas Graf, Centre for Genomic Regulation (Barcelona).

Friday 11 May 2012, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monitoring protein synthesis one codon at a time through ribosome profiling

User Jonathan Weissman, Howard Hughes Medical Institute, UCSF.

Thursday 10 May 2012, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Modeling stem cell differentiation on multiple scales

Tuesday, not Monday!

User Fabian Theis (Helmholtz Center Munich).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Tuesday 08 May 2012, 16:00-17:00

House Max Perutz Lecture Theatre, MRC LMB.

Investigating key effectors downstream of APC (adenomatous polyposis coli) deletion in vivo

Hutchison/MRC Research Centre Seminar

User Prof Owen Sansom, Beatson Institute, Glasgow.

Tuesday 08 May 2012, 12:00-13:00

ALK Hunting in Colorado - new drugs for lung cancer's new diseases

Note unusual day and time

User Dr Ross Camidge, University of Colorado Hospital (UCH) and the University of Colorado Cancer Center,.

Thursday 03 May 2012, 17:00-18:00

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Massively multi-parameter single cell data by Mass Cytometry: the technology of its acquisition and networks for its interpretation

User Scott Tanner, University of Toronto and DVS Sciences.

Thursday 03 May 2012, 15:00-16:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Local Translation at the Synapse

User Erin Schuman, Max Planck Institute.

Monday 30 April 2012, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

How end binding proteins recognise growing microtubule ends: from molecular structure to network functioning

User Thomas Surrey, Cancer Research UK, London Research Institute.

Thursday 26 April 2012, 16:15-18:00

CANCELLED

User Prof Richard Sullivan, Professor, Kings College London, Director, Centre for Global OncoPolicy & Health Kings Health Partners.

Tuesday 24 April 2012, 12:00-13:00

House Cancer Research UK Cambridge Research Institute, Room 215.

The ETS transcription factor ELF5 and breast cancer phenotype

User Chris Ormandy, Garvan Institute, Australia.

Friday 20 April 2012, 15:00-16:00

House Cancer Research UK Cambridge Research Institute, Room 215.

Gene expression programs controlling ER-negative breast cancer phenotype

User Alex Swarbrick, Garvan Institute, Australia.

Thursday 19 April 2012, 16:15-17:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Molecular mechanisms of complement activation and regulation

User Piet Gros, Utrecht University.

Thursday 19 April 2012, 14:00-16:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Machine learning applications in genetic regulation and cancer

User David Westhead (Leeds).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 16 April 2012, 14:00-15:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Ubiquitin flips the anaphase switch

User David Morgan, UCSF.

Friday 13 April 2012, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Towards unification of genetic and hierarchy models of tumor heterogeneity

Note unusual day

User John Dick, University of Toronto.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Wednesday 04 April 2012, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

John Kendrew Lecture 2012: Harnessing actin dynamics for endocytic trafficking events

User David Drubin, Berkeley.

Tuesday 03 April 2012, 16:15-18:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Always on guard: p53 dynamics in single living cells

Hutchison/MRC Research Centre Seminar

User Dr Alexander Loewer, Berlin Institute for Medical Systems Biology, Max Delbrueck Center, Germany.

Tuesday 03 April 2012, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

ShrinkSeq: a flexible and powerful method for Bayesian analysis of RNAseq data

Note the time change: 2pm (not 4pm)

User Mark van de Wiel (VU University Medical Center).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 02 April 2012, 14:00-15:00

House Seminar Room 2, Clinical School, Addenbrooke’s.

"Exploiting ASS1 deficiency in the treatment of mesothelioma"

User Dr Peter Szlosarek, Cancer Research UK Clinician Scientist, Senior Lecturer and Honorary Consultant in Medical Oncology, Barts and The London.

Tuesday 27 March 2012, 11:30-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Local interactions and genome-wide co-associations of proto-oncogenes: the short and the long of it.

User Cameron Osborne, Babraham Institute.

Friday 23 March 2012, 16:00-17:00

Clinical drug resistance in ovarian cancer

User James Brenton, CRUK Cambridge Research Institute.

Thursday 22 March 2012, 09:30-10:30

"Thalidomide and its analogues ; How molecules selected for anti-TNFa activity affect so many different pathways with direct binding with Cereblon mediating both anti proliferative and Immunomodulatory functions"

Individuals who are interested in meeting with any of the speakers should contact me asap. Thanks, Jonathan (jlh66@cam.ac.uk)

User Jerome B. Zeldis CEO of Celgene Global Health & Angus Dalgleish, St George's Hospital London.

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Tuesday 20 March 2012, 12:00-13:00

Evolution of developmental gene expression programs

User Itai Yanai (Technion).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 19 March 2012, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Pluripotency, Etc.

User Ihor Lemischka, Mount Sinai Medical Centre.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 15 March 2012, 13:00-14:00

Clinical lectures on prostate, bladder, renal and testis cancer

User David Neal, Cancer Research UK Cambridge Research Institute.

Thursday 15 March 2012, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Drugging the cancer genome

CANCELLED due to illness

User Prof. Paul Workman, Institute of Cancer Research, Surrey.

Tuesday 13 March 2012, 13:00-14:00

House CRI Lecture Theatre, Cambridge Research Institute.

"Re Service Reforms in the new Commissioning Landscape"

User Hannah Farrar, Director of Strategy and System Management, NHS, London.

Tuesday 13 March 2012, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

A Chemicogenetic approach to DNA repair implicates TORC2 and actin in survival of DNA breaks

User Susan Gasser, Friedrich Miescher Institute for Biomedical Research.

Monday 12 March 2012, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Disruptions on the Highways of Cell Communication

User Dario Alessi, MRC Protein Phosphorylation Unit, University of Dundee.

Tuesday 06 March 2012, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Dosage compensation: An intertwined world of RNA and chromatin remodeling

User Asifa Akhtar, Max Planck Institute of Immunobiology & Epigenetics, Freiburg, Germany.

Tuesday 06 March 2012, 11:45-12:45

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Modelling in systems genetics: computational approaches for discovering disease networks

User Tom Michoel (FRIAS Freiburg).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 05 March 2012, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Interactome Networks and Human Disease

Alkis Seraphim memorial lecture

User Marc Vidal, Dana-Farber Cancer Institute, Harvard Medical School.

Thursday 01 March 2012, 17:00-18:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

The architecture and ppGpp-dependent expression of the primary transcriptome of Salmonella Typhimurium

User Dr. Arthur Thompson, Institute of Food Research, Norwich.

Tuesday 28 February 2012, 13:00-14:00

"DICER1 and miRNA processing - a novel paradigm in cancer predisposition"

User Dr Marc Tischkowitz, Dept of Medical Genetics, University of Cambridge.

Tuesday 28 February 2012, 12:00-13:00

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Why 90% of novel anticancer agents are ineffective in clinical trial – and what to do about it

User John Hickman, Coordinator, EU Innovative Medicines Initiative PREDECT, Paris.

Friday 24 February 2012, 09:30-10:30

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Cellular senescence as both a dynamic and a static phenotype

User Masashi Narita, Cambridge Research Institute.

Thursday 23 February 2012, 10:00-11:00

Functional breast cancer genomics: from basic biology to clinical application

**Talk postponed**

User Carlos Caldas, CRI.

Thursday 23 February 2012, 09:30-10:30

"Myeloproliferative neoplasms – JAK/STAT signalling and stem cell subversion"

User Prof Tony Green, University of Cambridge Department of Haematology.

Tuesday 21 February 2012, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Dynamics of Dpp signaling and proliferation control

User Marcos Gonzalez-Gaitan, Depts of Biochemistry & Molecular Biology, University of Geneva, Switzerland.

Tuesday 21 February 2012, 11:45-12:45

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structural and Biochemical Mechanisms of Synchronous Synaptic Transmission

User James Rothman, Yale University.

Tuesday 21 February 2012, 11:30-18:00

Cancer Research UK Cambridge Institute Imaging Seminars

Developing imaging approaches for novel cancer therapies

User Eric Aboagye, Imperial College, London.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Friday 17 February 2012, 13:00-14:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Chromosome Segregation and Genome Stability

User David Pellman, Dana-Farber Cancer Institute, Harvard Medical School.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 16 February 2012, 13:00-14:00

Imaging tumour responses to treatment

User Kevin Brindle, Dept. Biochemistry and Cambridge Research Institute.

Thursday 16 February 2012, 09:30-10:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Crick Lecture 2012: Consequences of Aneuploidy

User Angelika Amon, HHMI, MIT.

Wednesday 15 February 2012, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

HOW MUCH CAN ONE SEE BY (JUST) LOOKING: the case with Heterochromatin Protein 1

User Prof. Spyros Georgatos, University of Iannina, Greece.

Tuesday 14 February 2012, 13:00-14:00

"Radiotherapy toxicity, Radiogenomics and RAPPER"

User Dr Gill Barnett, Dept. of Oncology.

Tuesday 14 February 2012, 12:00-13:00

Centrosome Amplification: Cancer’s Friend or Foe?

User Dr Susana Godinho, Dana-Farber Cancer Institute.

Wednesday 08 February 2012, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Transcriptional control of EMT and malignant tumor progression

Hutchison/MRC Research Centre Seminar

User Prof Gerhard Christofori, University of Basel, Switzerland.

Tuesday 07 February 2012, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

THIS SEMINAR HAS BEEN CANCELLED

User Suzanne Eaton, Max Planck Institute of Molecular Cell Biology & Genetics, Dresden, Germany.

Tuesday 07 February 2012, 11:45-12:45

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Model Based Target Identification from Expression Data

User Neil Lawrence (University of Sheffield).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 06 February 2012, 16:00-17:00

Hutchison/MRC Research Centre Seminars

Nischarin, a novel tumor suppressor of breast cancer

User Prof Suresh K. Alahari, Stanley S. Scott Cancer Center, Louisiana State University, USA..

Monday 06 February 2012, 14:00-15:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

New concepts in host-pathogen interactions: lessons from Listeria

User Pascale Cossart, Institute Pasteur, Paris.

Thursday 02 February 2012, 16:15-18:00

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

A STAT3‐induced metabolic switch involved in tumour transformation mediates STAT3 addiction

User Valeria Poli, University of Turin.

Thursday 02 February 2012, 15:00-16:00

MRI and MRS in cancer research and cancer treatment

User John Griffiths, Cambridge Research Institute.

Thursday 02 February 2012, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Molecular mechanisms of the Polycomb/trithorax system

User Dr. Juerg Mueller, Department of Chromatin and Chromosome Biology, Max Planck Institute of Biochemistry, Munich, Germany.

Tuesday 31 January 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

How do enhancers and promoters interact and what are the consequences ?

User Doug Higgs, Weatherall Institute, Oxford,.

Friday 27 January 2012, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Structural basis of anaphase promoting complex assembly, substrate recognition and regulation by the mitotic checkpoint complex

User Prof. David Barford, Institute of Cancer Research, London.

Tuesday 24 January 2012, 13:00-14:00

House Sackler Lecture Theater on level 7 of the CIMR (Cambridge Institute for Medical Research).

“Imaging Biomarkers in Cancer”

User Prof. Fiona Gilbert, Dept. of Radiology.

Tuesday 24 January 2012, 12:00-13:00

House Biffen Lecture Theatre, Department of Genetics, Downing Site.

Multiscale dynamics in zebrafish gastrulation

User Nadine Peyrieras, CNRS-NED, Institute of Neurobiology, Gif-sur-Yvette, France.

Tuesday 24 January 2012, 11:45-12:45

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Functions of Dynamin A, Myosin IB and WASH in phagolysosome biogenesis, and the Exocyst in kiss-and-run exocytosis in Dictyostelium

User Thierry Soldati, University of Geneva.

Monday 23 January 2012, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Inflammatory skin disease and Cancer: Functions of AP-1 (Fos/Jun) in mice and humans

User Erwin Wagner, CNIO Madrid.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 19 January 2012, 13:00-14:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

The Search for Organizing Principles in Cancer Systems Biology

User Olaf Wolkenhauer (University of Rostock, www.sbi.uni-rostock.de).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 16 January 2012, 16:00-17:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Increased methylation variation across cancer types

User Kasper Daniel Hansen (Johns Hopkins).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Friday 13 January 2012, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Signaling through the ubiquitin system

User Wade Harper, Harvard Medical School.

Thursday 15 December 2011, 16:15-18:00

Neo-adjuvant radiochemotherapy in breast cancer

User Dr Alain Fourquet, Department of Radiation Oncology, Institut Curie, Paris.

Cancer Research UK Cambridge Institute Seminars in Cancer

Tuesday 13 December 2011, 12:00-13:00

CANCELLED Wnt signalling, Lgr5 stem cells and cancer

**This seminar has been cancelled**

User Hans Clevers, Hubrecht Institute.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 08 December 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Commitment and plasticity in the B cell lineage

User Research Institute of Molecular Pathology Vienna, Austria.

Tuesday 06 December 2011, 16:00-17:00

Integration of Cell Growth and Cell Metabolism by Myc

Hutchison/MRC Research Centre Seminar

User Prof Martin Eilers, Theodor-Boveri-Institute, University of Würzburg, Germany.

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Tuesday 06 December 2011, 12:00-13:00

RNAi libraries for high throughput phenotyping and drug resistance screening in the African trypanosome

User David Horn (LSHTM).

House Cancer Research UK Cambridge Research Institute, Room 215.

Monday 05 December 2011, 16:00-17:00

House Cancer Research UK Cambridge Research Institute, Room 215.

Novel risk biomarkers based on DNA repair for early detection and prevention of lung cancer.

User Zvi Livneh, Weizmann Institute of Science.

Monday 05 December 2011, 10:30-11:30

From gene regulation to cancer - arginine methylation makes its mark

User Dr Clare Davies, University of Manchester.

Thursday 01 December 2011, 14:30-15:30

Cancer Therapeutics

User Duncan Jodrell, Cambridge Research Institute and Department of Oncology.

Thursday 01 December 2011, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Protease-mediated protein processing and the "forgotten" co-translational alpha-N-acetylation revealed by positional proteomics

Please note - CANCELLED due to illness

User Prof. Kris Gevaert, VIB Life Science Research Institute, Gent, Belgium.

Tuesday 29 November 2011, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Genomic encoding of shape in ascidian embryos

User Patrick Lemaire, CRBM, Montpellier, France.

Tuesday 29 November 2011, 11:45-12:45

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structural and Mechanistic Studies of the Anaphase Promoting Complex

User David Barford, Institute of Cancer Research.

Thursday 24 November 2011, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

RNAi-based molecular computing for cancer cell detection

User Yaakov (Kobi) Benenson (ETH Zurich BSSE).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 21 November 2011, 16:00-17:00

Modeling Minimal Residual Disease and Acquired Cancer Drug Resistance in vitro

User Sreenath Sharma, Novartis Institutes for BioMedical Research, USA.

Friday 18 November 2011, 14:30-15:30

Pyruvate kinase M2 and cancer metabolism

User Dimitris Anastasiou, Beth Israel Deaconess Medical Center, Harvard Medical School, USA.

Cancer Research UK Cambridge Institute Seminars in Cancer

Thursday 17 November 2011, 14:30-15:30

The intrinsic and extrinsic regulation of stem cells self-renewal

User Sean J Morrison, Children’s Research Institute, University of Texas Southwestern Medical Center.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 17 November 2011, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The Evolution of Enzyme Mechanisms and Functional Diversity

User Janet Thornton, EMBL-EBI.

Tuesday 15 November 2011, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

The Spliceosome: the machine that removes introns from pre-mRNA

User Kiyoshi Nagai, MRC LMB, Cambridge.

Tuesday 15 November 2011, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Stem cells, cell-cell interactions, and homeostasis in the Drosophila intestine

User Bruce Edgar, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Tuesday 15 November 2011, 11:45-12:45

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Drug resistance and disease progression: lessons from prostate cancer

User Charles Sawyers, Memorial Sloan Kettering Cancer Centre.

Thursday 10 November 2011, 13:00-14:00

Barrett's oesophagus as a model for early cancer detection/treatment

User Rebecca Fitzgerald, Hutchison/MRC Research Centre.

Thursday 10 November 2011, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Protein/Lipid Interactions in Membranes via Multiscale Simulations

User Prof. Mark Sansom, Department of Biochemistry, University of Oxford.

Tuesday 08 November 2011, 13:00-14:00

House Biffen Lecture Theatre, Department of Genetics, Downing Site.

Guidance mechanisms in collective cell migration

User Pernille Rorth, Institute of Molecular & Cell Biology, Singapore.

Tuesday 08 November 2011, 11:30-12:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Long non-coding and extracoding RNAs in normal haematopoiesis and leukemia

User Dan Tenen, Cancer Science Institute of Singapore and Harvard Medical School.

Monday 07 November 2011, 16:00-17:00

Mechanisms and regulation of centrosome biogenesis

User Jay Gopalakrishnan, Harvard University, USA.

Monday 07 November 2011, 11:00-12:00

RB collaborators in cancer

User David MacPherson, Carnegie Institution, Baltimore, USA.

Thursday 03 November 2011, 15:00-16:00

The story of the intracellular recycling factory- mTOR autophagy spatial coupling compartment (TASCC) augments secretory phenotypes

User Andy Young, CRUK Cambridge Research Institute.

Wednesday 02 November 2011, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

New biological insights from single molecule experiments

User Prof. David Klenerman, Department of Chemistry, Cambridge.

Tuesday 01 November 2011, 13:00-14:00

House Max Perutz Lecture Theatre, MRC LMB.

Cancer Gene Discovery in the Mouse

Hutchison/MRC Research Centre Seminar

User Dr David Adams, Wellcome Trust Sanger Institute.

Tuesday 01 November 2011, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structural Studies on the Regulation of Protein Kinases: EGFR and CamK-II

User John Kuriyan, HHMI, University of California, Berkeley.

Monday 31 October 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Neuronal plasticity: from synapses to the axon initial segment

User Juan Burrone, Kings College London.

Friday 28 October 2011, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Inferring mechanisms of gene regulation from patterns of evolutionary divergence

User Itay Tirosh (Weizmann Institute).

House Cancer Research UK Cambridge Research Institute, Room 215.

Wednesday 26 October 2011, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Title to be confirmed

User Prof. Matthias Mann, Department of Proteomics and Signal transduction, Max Planck Institute of Biochemistry, Munich, Germany.

Tuesday 25 October 2011, 13:00-14:00

Metabolic synthetic lethality as a new strategy for cancer therapy

User Christian Frezza, Beatson Institute for Cancer Research, Glasgow.

Tuesday 25 October 2011, 12:00-13:00

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

The use of cell lines – promises and pitfalls

User Ian Freshney, Cancer Research UK Centre for Oncology and Applied Pharmacology, University of Glasgow.

Tuesday 25 October 2011, 10:30-11:30

Cancer Research UK Cambridge Institute Seminars in Cancer

Transcriptional Regulation of Cell State

User Richard Young, Whitehead Institute for Biomedical Research and M.I.T..

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 20 October 2011, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

The functional significance of the modular architecture of plant cell wall degrading enzymes

User Prof. Harry J. Gilbert, School of Biomedical Sciences, Newcastle University.

Tuesday 18 October 2011, 13:00-14:00

‘Genetic predisposition to cancer’

User Prof Bruce Ponder, Cancer Research UK Cambridge Research Institute.

Tuesday 18 October 2011, 12:00-13:00

House Biffen Lecture Theatre, Department of Genetics, Downing Site.

The genetics of cell competition and synthetic species

User Eduardo Moreno, Institute of Cell Biology, University of Bern, Switzerland.

Tuesday 18 October 2011, 11:30-12:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Mass spectrometric analysis of lipid signalling in cancer

User Prof. Michael J. O. Wakelam, Babraham Institute.

Tuesday 11 October 2011, 13:00-14:00

House Cancer Research UK Cambridge Research Institute, Room 215a.

Regulation of tumour adaptability in endocrine resistant breast cancer

User Leonie Young, Royal College of Surgeons, Dublin.

Tuesday 11 October 2011, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

DNA-dependent protein kinase is a DNA sensor for IRF-3-dependent innate immunity

User Geoffrey Smith, Department of Pathology Cambridge.

Thursday 06 October 2011, 16:15-18:00

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

So what is the real function of chromatin?

User David Bazett-Jones: Senior Scientist, The Hospital for Sick Children, Professor, Department of Biochemistry, University of Toronto.

Tuesday 04 October 2011, 13:00-14:00

Tumour-stroma Interactions in Breast Cancer

Hutchison/MRC Research Centre Seminar

User Prof Clare Isacke, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research.

Tuesday 04 October 2011, 12:00-13:00

House Biffen Lecture Theatre, Department of Genetics, Downing Site.

Reproductive organ development in the mouse

User Richard Behringer, Dept of Genetics, University of Texas, USA.

Tuesday 04 October 2011, 11:30-12:30

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Translational Cancer Genomics Research

User Affymetrix.

Tuesday 04 October 2011, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Chromatin-mediated regulation of gene expression in mouse ES cells

User Helle Jørgensen (University of Cambridge).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 03 October 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

mRNA-tRNA translocation intermediates by cryo-EM: a look at the free-energy landscape from a single sample.

User Joachim Frank, Columbia University.

Friday 30 September 2011, 16:15-18:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Chromatin, chromosome and nuclear dynamics, links to genome function

User Peter Fraser, Babraham Institute.

Friday 23 September 2011, 16:00-17:00

DNA repair inhibitors in cancer treatment

User Prof Hilary Calvert, UCL Cancer Institute.

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Tuesday 20 September 2011, 12:00-13:00

Adult stem cell fate: a laboratory for statistical physics

User Ben Simons (University of Cambridge).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 19 September 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Molecular and cellular mechanisms for memory allocation in neuronal networks

User Alcino Silva, UCLA.

Friday 16 September 2011, 16:15-18:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Genome-wide DNA methylation analysis in stem cells and cancer

User Christoph Bock, Broad Institute.

Friday 16 September 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Genetic dissection of emotion circuits in flies and mice - Francis Crick Lecture 2011

User Dr David Anderson, California Institute of Technology, USA.

Friday 09 September 2011, 16:00-18:00

House Max Perutz Lecture Theatre, MRC LMB.

Haploid Genetic Screens in Human Cells

Hutchison/MRC Research Centre Seminar

User Dr Thijn Brummelkamp, Netherlands Cancer Institute.

Tuesday 06 September 2011, 12:00-13:00

House Cancer Research UK Cambridge Research Institute, Room 215.

HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 Herceptin in breast cancer

User Anthony Kong, Weatherall Institute of Molecular Medicine, University of Oxford.

Thursday 25 August 2011, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Self-assembled DNA-nanostructure tools for molecular biophysics

User William Shih, Harvard Medical School.

Monday 25 July 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

PDBe - Bringing Structure to Biology

User Gerard Kleywegt, EMBL-EBI.

Thursday 14 July 2011, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Modeling non-familial colon cancer susceptibility in mice

User David Threadgill, Department of Genetics, North Carolina State University.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 14 July 2011, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuberculosis Treatment Dicta from the Zebrafish

User Lalita Ramakrishnan, University of Washington.

Thursday 07 July 2011, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Integrated Solutions in Cancer Genomics

User Edison Liu, Genome Institute of Singapore.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 07 July 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Development of hematopoietic stem cells: an outline of the final scenario

User Shin-Ichi Nishikawa, Riken CDB, Kobe.

Wednesday 06 July 2011, 10:00-11:00

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Learnings from kinase inhibitors for cancer therapy

User Gideon Bollag (Senior Vice President of Research for Plexxikon Inc., California).

Friday 01 July 2011, 16:00-17:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Perturbation Biology of Cancer Cells

User Chris Sander (MSKCC).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Wednesday 29 June 2011, 15:00-16:00

The ATM-mediated DNA damage response: moving between the forest and the trees

Hutchison/MRC Research Centre Seminar

User Dr Yossi Shiloh, Tel Aviv University, Israel.

Tuesday 28 June 2011, 12:00-13:00

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Progress towards a biomarker discovery-to-development pipeline in clinical proteomics

User Michael Gillette, Broad Institute of MIT and Harvard.

Monday 27 June 2011, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Autoantibodies against NMDA receptors and other neuronal targets: the widening spectrum of antibody-mediated CNS disorders

User Angela Vincent, University of Oxford.

Wednesday 22 June 2011, 14:30-16:15

‘Viral and host contributions to cervical carcinogenesis’

User Dr Nick Coleman, Department of Pathology & Hutchison/MRC Research Centre.

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Tuesday 21 June 2011, 12:00-13:00

Phylogenetic Inference of Multidomain Evolution

User Dannie Durand (Carnegie Mellon University, Pittsburgh).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 20 June 2011, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Why do we need a Fanconi Anaemia DNA repair pathway?

User KJ Patel, MRC LMB, Cambridge.

Friday 17 June 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Exploring and exploiting chromosome repair and segregation mechanisms in cancer

User Ashok Venkitaraman, MRC Cancer Cell Unit.

Thursday 16 June 2011, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Changing Cancer Mortality

User Richard Peto, Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 16 June 2011, 13:00-14:00

"Advances in Head and Neck Radiotherapy"

User Dr Chris Nutting, Royal Marsden Hospital.

Tuesday 14 June 2011, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Genetics and therapy of AML: role of mutations in the epigenetic machinery

User Ross Levine, Memorial Sloan-Kettering, New York.

Thursday 09 June 2011, 13:30-14:30

"Developing Medicines for Pancreatic Cancer"

User Dr Dave Tuveson, CRUK Cambridge Research Institute.

Tuesday 07 June 2011, 12:00-13:00

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Metabolomic Studies of Cancer Using 13C Tracer Substrates and Model Fitting

User Laszlo G Boros, Associate Professor of Paediatrics, UCLA School of Medicine, and Chief Scientist, SiDMAP LLC, Los Angeles, USA.

Thursday 02 June 2011, 17:00-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Visualizing vesicle and virus budding by electron microscopy

User John Briggs, EMBL.

Wednesday 01 June 2011, 11:30-13:15

SOCCAR trial: an update

User Dr Joe Maguire, Consultant Clinical Oncologist, Clatterbridge Centre for Oncology.

Tuesday 31 May 2011, 12:00-13:00

Genomic Imprinting and Cancer

User Adele Murrell, CRUK Cancer Research Institute.

Thursday 26 May 2011, 09:30-10:30

“What lessons can we learn from transcriptional evolution in cancer research?”

User Dr Duncan Odom, CRUK Cambridge Research Institute.

Tuesday 24 May 2011, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Genetic Architecture of Leukaemia

User Mel Greaves, Institute of Cancer Research.

Thursday 19 May 2011, 16:15-18:00

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Haloplex technology: a genome capture system for next generation sequencing

User Olle Ericsson, Halo Genomics.

Thursday 19 May 2011, 14:30-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Delivery Boy to Reporter: Unusual DNA’s journey through a worm-whole

User Yamuna Krishnan, National Centre for Biological Sciences Bangalore.

Tuesday 17 May 2011, 16:15-18:00

CANCELLED

User Prof. Roy Rampling, University of Glasgow and The Beatson Cancer Centre, Glasgow.

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Tuesday 17 May 2011, 12:00-13:00

Allele specific expression design using short read DNA sequencing and application to the genetics of autoimmune disorders

User Vincent Plagnol (UCL).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 16 May 2011, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The development of HSCs: endothelial to hematopoietic transition

User Elaine Dzierzak, Erasmus MC, Rotterdam.

Friday 13 May 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

A primer on DNA origami and why molecular biologists might care

User Hendrik Dietz, TU Munich.

Thursday 12 May 2011, 16:15-18:00

"Multi-site post-translational modification as a quantitative regulator of transcriptional output during neurogenesis"

User Dr Anna Philpott, Department of Oncology, MRC-Hutchison Research Centre.

Tuesday 10 May 2011, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Genome-wide analysis of AID activity and AID-mediated translocations in B lymphocytes

User Rafael Casellas, NIH.

Friday 06 May 2011, 16:15-18:00

CANCELLED

Hutchison/MRC Research Centre Seminar

User Prof Sibylle Mittnacht, The Institute of Cancer Research.

Tuesday 03 May 2011, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

The developmental biology toolbox in basic and translational studies

User Chris Wylie.

Tuesday 03 May 2011, 11:30-12:30

CANCELLED

User Dr Vincent Gnanapragasam, Hutchison/MRC Research Centre & Addenbrooke's Hospital.

Cancer Research UK Cambridge Institute Imaging Seminars

Tuesday 26 April 2011, 12:00-13:00

Genes into Geometry: Imaging for mouse phenotyping

User Mark Henkelman, Department of Medical Biophysics and Medical Imaging, University of Toronto.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 21 April 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Studying precancerous stem cells in mouse models of T cell leukaemia

User Matthew McCormack, WEHI, Melbourne.

Monday 18 April 2011, 10:30-11:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

CRUK computational biology day

User Speaker to be confirmed.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 18 April 2011, 09:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Feldberg Prize Lecture: Biogenesis of iron-sulfur proteins in eukaryotes

User Professor Roland Lill, Philipps University Marburg, Germany.

Friday 15 April 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Controlling Recombination

User Simon Boulton, CRUK Clare Hall Laboratories.

Thursday 14 April 2011, 16:15-18:00

Signal transduction and membrane trafficking

User Ian Mills, CRUK Cambridge Research Institute.

Thursday 14 April 2011, 09:30-10:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae

User Anne-Claude Gavin, EMBL.

Tuesday 12 April 2011, 16:15-18:00

"Somatic Genetics of Human Cancer - Moving Towards Large Scale Resequencing of Cancer Genomes"

User Dr Andy Futreal, The Wellcome Trust Sanger Institute, Hinxton.

Tuesday 12 April 2011, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Aurora B kinase regulates chromosome architecture and chromosome segregation

User Yoshinori Watanabe, Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.

Friday 08 April 2011, 11:30-12:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Milstein Lecture 2011: How the endoplasmic reticulum gets into shape

User Tom Rapoport, Harvard Medical School.

Thursday 07 April 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The Chemical Biology of Large-Scale Transcriptome Analysis

User Kevin Weeks, University of North Carolina.

Wednesday 06 April 2011, 11:30-13:15

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Do modules or pathways help predict breast cancer outcome?

User Gunnar Klau (Centrum Wiskunde & Informatica, Amsterdam).

House Cancer Research UK Cambridge Research Institute, Room 009.

Monday 04 April 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The Cellular Basis for the Cancer-Related Phenomena of Immune Suppression and Cachexia

User Doug Fearon.

Thursday 31 March 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The Female Side of Fertilization: Crystal Structure of Vertebrate Sperm Receptor ZP3

User Luca Jovine, Karolinska Institute.

Monday 28 March 2011, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

From data to bench to bedside - prognostic markers and therapeutic targets in breast cancer

User Gyan Bhanot (Rutgers).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 28 March 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The Structural Basis of Ubiquitin Signalling

User Cynthia Wolberger, Johns Hopkins University.

Friday 25 March 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Repeat Proteins:Versatile frameworks for understanding and engineering protein structure and function

User Lynne Regan, Yale University.

Monday 21 March 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Non-classical means for regulating small G-proteins

User Shehab Ismail, Max Planck Institute Dortmund.

Thursday 17 March 2011, 16:15-18:00

"The Cambridge breast cancer program- recent progress"

User Dr Carlos Caldas, CRUK Cambridge Research Institute.

Tuesday 15 March 2011, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Scaffolds and adaptors in DNA-damage response signalling: a structural perspective

User Dr. Stephen Smerdon, MRC National Institute of Medical Research, London.

Tuesday 08 March 2011, 13:00-14:00

"FGF-2, S6 Kinase 2 and Chemo-resistance in Lung Cancer"

User Prof. Michael Seckl, Imperial College, London and Charing Cross Hospital.

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Tuesday 08 March 2011, 12:00-13:00

Evidence of non-random mutation rates suggests a risk management strategy for bacterial evolution

User Nicholas Luscombe (EBI).

House Cancer Research UK Cambridge Research Institute, Room 215.

Monday 07 March 2011, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

How do cells establish and maintain sister chromatid cohesion?

Alkis Seraphim lecture - please note the later starting time

User Prof. Kim Nasmyth, Department of Biochemistry, University of Oxford.

Tuesday 01 March 2011, 17:00-18:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Modeling malignant growth in Drosophila

User Cayetano Gonzalez, Cell Division Laboratory, Institute for Research in Biomedicine, Barcelona, Spain.

Tuesday 01 March 2011, 11:30-12:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Genetic complexity in MPN and MDS/MPN

User Nick Cross, Univeristy of Southampton.

Friday 25 February 2011, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Combining science and adventure: On the hunt for new fluorescent proteins in tropical coral reefs on the Danish Galathea 3 Expedition.

User Prof. Peter Roepstorff, University of Southern Denmark.

Tuesday 22 February 2011, 13:00-14:00

Mesothelioma: a disease of our time

User Dr David Gilligan, Addenbrooke's Hospital.

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Tuesday 22 February 2011, 12:00-13:00

Intrinsically Unstructured Proteins: Regulation and Disease

User Madan Babu (MRC Laboratory of Molecular Biology).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 21 February 2011, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Analysis of Sprouty2 in human prostate carcinogenesis

User Hing Leung, Beatson Institute for Cancer Research.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 21 February 2011, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Accuracy of codon reading by transfer RNAs

User Måns Ehrenberg.

Friday 18 February 2011, 11:30-13:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Transport mechanism and membrane interactions of the cation pumps

User Poul Nissen, Aarhus University, Denmark.

Thursday 17 February 2011, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

MAL: linking the actin cytoskeleton to transcriptional regulation

User Richard Treisman, Cancer Research UK London Research Institute, Lincoln's Inn Fields.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 17 February 2011, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

The road to the structure of the ribosome: A personal account

Special Postdoc seminar - please note the later starting time

User Venki Ramakrishnan, MRC LMB, Cambridge.

Tuesday 15 February 2011, 17:00-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Pre- and postsynaptic NMDA receptors in neocortical synaptic plasticity

User Ole Paulsen, Department of Physiology, University of Cambridge.

Tuesday 15 February 2011, 16:15-18:00

"Targetting pre-neoplasia in the bronchus"

User Dr Robert Rintoul, Papworth Hospital.

Tuesday 15 February 2011, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Reprogramming the code of life

User Jason Chin, MRC Laboratory of Molecular Biology, Cambridge, UK.

Tuesday 15 February 2011, 11:45-12:45

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Transcription and R-loops as a source of genome instability

User Andrés Aguilera, University of Seville.

Tuesday 08 February 2011, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Protein dynamics illuminated by studies of bacterial behaviour

User Prof. Judy Armitage, University of Oxford.

Tuesday 08 February 2011, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

In vitro and in vivo single molecule studies of chromosome replication and segregation

User David Sherratt, University of Oxford.

Monday 07 February 2011, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Theoretical models of the development of the nervous system

User Stephen Eglen (University of Cambridge).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 07 February 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Genetic approaches to understand and manipulate retinal circuit function

User Botond Roska, Friedrich Miescher Institute for Biomedical Research.

Thursday 03 February 2011, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Discovery of the mechanism that enables the provision of nutrients to proliferating cells

User Prof. Sir Salvador Moncada, University College London.

Tuesday 01 February 2011, 13:00-14:00

Application of Systems Biology Approaches to Study Cell Signalling and Transcription

Hutchison/MRC Research Centre Seminar

User Prof Mike White, University of Liverpool.

Tuesday 01 February 2011, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Cancer as developmental disease: chance and necessity in networks dynamics during somatic evolution of cancer cells

User Sui Huang, Institute for Biocomplexity and Informatics, University of Calgary, Canada.

Tuesday 01 February 2011, 11:45-12:45

House Gurdon Institute Tearoom, Tennis Court Road.

Moving stem cell discoveries into translation

User Alan Trounson, California Institute for Regenerative Medicine, San Francisco, USA.

Tuesday 01 February 2011, 10:00-10:45

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Off-the-shelf models of chromosomal translocations and using antibody fragments as cancer drug surrogates

User Terry Rabbitts, Leeds Institute of Molecular Medicine.

Monday 31 January 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Crystal structures of bacterial and yeast ribosomes

User Marat Yusupov, Illkirch, France.

Thursday 27 January 2011, 16:15-18:00

Control of DNA Replication

User Ron Laskey, MRC Cancer Cell Unit, MRC-Hutchison Research Centre.

Thursday 27 January 2011, 09:30-10:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Interactions of Cancer Stem Cells with their Niches are Essential for Breast Cancer Metastasis

User Dr Joerg Huelsken, Swiss Federal Univerity of Technology, Lausanne, Switzerland.

Tuesday 25 January 2011, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Peptide aptamers as precision tools for dissecting signaling pathways: application to Nerve Growth Factor signaling

User Prof. Brian B. Rudkin CNRS/ENS Universite' Lyon, France.

Tuesday 25 January 2011, 13:00-14:00

"Leukaemia stem cells: how normal stem cell function is subverted in haematological malignancies"

User Dr Brian Huntly, Department of Haematology.

Cancer Research UK Cambridge Institute Seminars in Cancer

Tuesday 25 January 2011, 12:00-13:00

Reverse Phenotyping: Towards an integrated (epi)genomic approach to complex phenotypes and common disease.

User Stephan Beck, UCL Cancer Institute.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 20 January 2011, 13:00-14:00

Systems approaches to understanding transcriptional regulation

User Duncan Odom, CRUK Cambridge Research Institute.

Thursday 20 January 2011, 09:30-10:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

MAL: linking the actin cytoskeleton to transcriptional regulation

User Dr. Richard Treisman, CRUK London Research Institute.

Tuesday 18 January 2011, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

The genetics and cell biology of mammalian Hedgehog signaling

User Kathryn Anderson, Sloan-Kettering Institute, New York, USA.

Tuesday 18 January 2011, 11:30-12:30

House level 2 seminar room, Gurdon Institute Tennis Court Road.

Evolution of Cerebral Cortical Development

User Zoltan Molnar (DPAG, Oxford).

Friday 14 January 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The mechanism of retroviral DNA integration through X-ray structures of its key intermediates

User Peter Cherepanov, Faculty of Medicine, Imperial College.

Tuesday 11 January 2011, 16:15-18:00

“Breast MRI by the Shutter-Speed Method: Elimination of Unnecessary Breast Biopsies"

User Dr Charles S. Springer, Jr., Advanced Imaging Research Centre. Oregon Health & Science University.

Tuesday 21 December 2010, 12:00-13:00

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Breast MRI by the Shutter-Speed Method: Elimination of Unnecessary Breast Biopsies

User Charles S. Springer Jr, Oregon Health and Science University, USA.

Tuesday 21 December 2010, 12:00-13:00

RCC Cinderella comes of age

User Prof. Tim Eisen, Dept. of Oncology, University of Cambridge & Addenbrooke's Hospital.

Tuesday 14 December 2010, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structural biology of bacterial secretion systems

User Gabriel Waksman.

Monday 13 December 2010, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Protein folding homeostasis and prion-like propagation of protein aggregation in neurodegenerative disease

User Ron Kopito, Stanford University, CA USA.

Friday 10 December 2010, 14:15-16:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Title to be confirmed

Special Lecture - note unusual day/time

User Marc Kirschner, Professor of Systems Biology, Harvard Medical School, Boston, USA.

Wednesday 08 December 2010, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structural insights into the process of co-translational targeting of membrane proteins and translation initiation in eukaryotes

User Nenad Ban.

Monday 06 December 2010, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Using association-based genetics to understand basic biology

User Ewan Birney (EBI).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 06 December 2010, 16:00-17:00

Neuroblastoma- Disordered Developmental Programs Contribute to Tumorigenesis

Hutchison/MRC Research Centre Seminar- Please note change to regular time and date

User Prof Carol Thiele, National Cancer Institute, USA.

Thursday 02 December 2010, 14:30-15:30

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Cell Surface Signalling Assemblies

User Prof. Yvonne Jones, University of Oxford.

Tuesday 30 November 2010, 13:00-14:00

"Susceptibility to Cancer - What's New?"

User Prof Doug Easton, Strangeways Research Laboratory.

Tuesday 30 November 2010, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

TBA

User Yohanns Bellaiche (Institut Curie, Paris, France).

Tuesday 30 November 2010, 11:30-12:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Integrative Network Biology and Cellular Information Processing

User Rune Linding (ICR).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 29 November 2010, 16:00-17:00

Expression of pluripotency factors in lung cancer – new opportunities for therapy?

User Mike Gonzalez, MRC Cancer Cell Unit.

Monday 29 November 2010, 14:30-15:30

Tumour suppressors mechanisms and cellular senescence

User Masashi Narita, CRUK Cambridge Research Institute.

Thursday 25 November 2010, 09:30-10:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Femtosecond Membrane-Protein Nanodiffraction using a Hard X-Ray Laser

User John Spence, Arizona State University.

Tuesday 23 November 2010, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

New insights into the Fanconi Anaemia Tumour Suppressor Pathway from Slime mould to Mice

User Dr. KJ Patel, MRC LMB, Cambridge.

Tuesday 23 November 2010, 13:00-14:00

Targeting NG2 Cells in Glioblastoma

User Dr Colin Watts, Cambridge Centre for Brain Repair.

Tuesday 23 November 2010, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Dehydrated but unharmed? – the mass spectrometry of protein complexes

User Professor Carol Robinson, Department of Chemistry, Oxford University.

Monday 22 November 2010, 16:15-18:00

Myc inhibition has a dramatic therapeutic impact in diverse mouse models of cancer

User Laura Soucek, Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco.

Monday 22 November 2010, 15:00-16:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Deconstructin oncogenesis and tumour suppression to find the best cancer drug targets

User Gerard Evan, Department of Biochemistry, Unversity of Cambridge.

Thursday 18 November 2010, 16:15-18:00

Oncogenes and Tumour Suppressors 1 & 2

Note extended session - finish time 11 am

User Ashok Venkitaraman & Dave Tuveson; Hutchison/MRC Research Centre & Cambridge Research Institute.

Thursday 18 November 2010, 09:30-11:00

p53-based cancer therapy: potential & limitations

User Carla Martins, CRUK Cambridge Research Institute.

Wednesday 17 November 2010, 12:00-13:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Mass spectrometry: A powerful tool for the biosciences

User Prof. Ann Dell, Imperial College, London.

Tuesday 16 November 2010, 13:00-14:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Regulation of microRNA biogenesis and function

User Javier F Caceres, MRC Human Genetics Unit, Edinburgh.

Monday 15 November 2010, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

The evolution and regulation of gene expression levels in mammals

User John Marioni (EBI).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 15 November 2010, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Nucleocytoplasmic Transport Machinery and Pathways: Cell Cycle Regulation and Stress Response

User Naoko Imamoto, Cellular Dynamics Laboratory, RIKEN ASI.

Monday 15 November 2010, 14:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Insights into the molecular basis of myelodysplastic syndrome

User Ben Ebert, Department of Medicine, Harvard Medical School.

Thursday 11 November 2010, 15:00-16:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Inflammation, metabolism, ageing and cancer: Dangerous Liaisons

User Michael Karin, University of California, San Diego.

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 11 November 2010, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Human disease in a dish: modelling premature aging and neurological disorders using induced pluripotent stem cells

User Alan Colman (Stem Cell Research, King’s College London, UK, Singapore Stem Cell Consortium and A*Star Institute of Medical Biology, Singapore).

Tuesday 09 November 2010, 11:30-12:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Mitosis and Meiosis in live mammalian cells: From genome wide RNAi profiling to homologous chromosome segregation

User Jan Ellenberg, EMBL, Heidelberg, Germany.

Friday 05 November 2010, 14:15-16:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

The architecture of respiratory complex I: 'steam engine' of the cell

User Leonid Sazanov, Mitochondrial Biology Unit, MRC, Cambridge.

Tuesday 02 November 2010, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Does epigenetic gene regulation extend beyond histone modifications?

User Wendy Bickmore (MRC Human Genetics Unit, Edinburgh, UK).

Tuesday 02 November 2010, 11:30-12:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Finding interesting clusters using Bayesian data fusion

User Richard Savage (University of Warwick).

House Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 01 November 2010, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Watching molecules one-by-one: in vivo and in vitro single-molecule studies of molecular machines that replicate and segregate chromosomes

User Prof. David Sherratt, University of Oxford.

Tuesday 26 October 2010, 13:00-14:00

"Chromosome Translocations and Tumour Suppressors in Breast Cancer"

User Dr Paul Edwards, Hutchison/MRC Research Centre.

Tuesday 26 October 2010, 12:00-13:00