Lectures in Cancer Biology

Epidemiology

Paul Pharoah, CRUK Genetic Epidemiology Unit, Strangeways Research Laboratory.

CRUK CI Lecture Theatre.

Thursday 05 March 2015, 09:30-10:30

Cambridge Oncology Seminar Series

Systems Biology of Cancer

Host: Hutchison/MRC Research Centre Graduate Student Society

Professor Jussi Taipale, Department of Biosciences and Nutrition, Karolinska Institute, Sweden .

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 03 March 2015, 12:00-13:00

Lectures in Cancer Biology

in vivo models

Please note: this talk takes place on WEDNESDAY!

Suzanne Turner, Department of Pathology.

CRUK CI Lecture Theatre.

Wednesday 25 February 2015, 09:30-10:30

Gurdon Institute Seminar Series

The atomic structure of the APC/C: implications for understanding regulation and mechanism of protein ubiquitination

David Barford, MRC-LMB, Cambridge.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 24 February 2015, 11:30-12:30

MRC LMB Seminar list

Prion propagation and neurotoxicity

Prof. John Collinge, UCL .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 19 February 2015, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Cell-specific analysis of tumour-stroma signalling

Dr Claus Jorgensen (CRUK Manchester Institute).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 19 February 2015, 13:00-14:00

Lectures in Cancer Biology

Genomic technologies

Jason Carroll, Cancer Research UK Cambridge Institute.

CRUK CI Lecture Theatre.

Thursday 19 February 2015, 09:30-10:30

Lectures in Cancer Biology

Computational Biology

This talk was postponed from February 5 2015

Florian Markowetz, Cancer Research UK Cambridge Institute.

CRUK CI Lecture Theatre.

Thursday 12 February 2015, 09:30-10:30

Cambridge Haematopoiesis Seminars

Predictive Engineering of Cell Fate

Please note that this seminar is at 10am

Prof. Peter Zandstra, University of Toronto.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Wednesday 11 February 2015, 10:00-11:00

Lectures in Cancer Biology

Computational biology

This lecture has been postponed. It will now take place on February 12 at 9:30.

Florian Markowetz, Cancer Research UK Cambridge Institute.

CRUK CI Lecture Theatre.

Thursday 05 February 2015, 09:30-10:30

Cambridge Oncology Seminar Series

MYC Oncoproteins act as Epigenetic Modifiers

Hutchison/MRC Research Centre Seminar - Host by: Dr Anna Philpott

Dr Frank Westermann, Research Group Neuroblastoma Genomics, DKFZ, Heidelberg.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 03 February 2015, 12:00-13:00

Gurdon Institute Seminar Series

Biological insights into mutagenesis through modern sequencing technologies

Serena Nik-Zainal, Wellcome Trust Sanger Institute, Hinxton, Cambridge .

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 03 February 2015, 11:30-12:30

MRC LMB Seminar list

Taming a protein destruction machine

Nicolas Thoma, Friedrich Miescher Institute for Biomedical Reearch, Basel, Switzerland.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 29 January 2015, 16:15-18:00

Cambridge Haematopoiesis Seminars

Opening up the stem cell niche for human and mouse hematopoietic stem cells

Please note the different location of this seminar

Prof. Claudia Waskow, Center for Regenerative Therapies TU Dresden.

Clifford Allbutt Lecture Theatre, Clifford Allbutt Building (former LMB building).

Thursday 29 January 2015, 16:00-17:00

Lectures in Cancer Biology

Stem cells and cancer

Phil Jones, MRC Cancer Unit.

CRUK CI Lecture Theatre.

Thursday 29 January 2015, 09:30-10:30

Cambridge Oncology Seminar Series

“Optimizing Image Guided Radiotherapy for Patient Benefit”

Host: Professor Neil Burnet

Dr Peter Remeijer, Medical Physicist NKI /Avl, Amsterdam.

CRUK CI Lecture Theatre.

Tuesday 27 January 2015, 12:00-13:00

Lectures in Cancer Biology

Senescence, cell death and apoptosis

Masashi Narita, Cancer Research UK Cambridge Institute.

CRUK CI Lecture Theatre.

Thursday 22 January 2015, 09:30-10:30

Gurdon Institute Seminar Series

Transcriptional regulation during developmental transitions: a view from 3D

Eileen Furlong, EMBL, Heidelberg, Germany.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 20 January 2015, 11:30-12:30

Lectures in Cancer Biology

Metastasis

Sakari Vanharanta, Department of Oncology.

CRUK CI Lecture Theatre.

Thursday 15 January 2015, 09:30-10:30

Cambridge Oncology Seminar Series

Explaining the reduction in ovarian cancer mortality 1977 to 2014

Host: Dr Marc Tischkowitz

Dr Steven Narod, Director, Familial Breast Cancer Research Unit, Women's College Research Institute, Toronto, Canada.

CRUK CI Lecture Theatre.

Tuesday 13 January 2015, 12:00-13:00

Cambridge Oncology Seminar Series

Ovarian Cancer in Transition

Host: Dr Christine Parkinson

Mr Douglas Levine, Gynecology Service, Department of Surgery.

CRUK CI Lecture Theatre.

Tuesday 16 December 2014, 12:00-13:00

MRC LMB Seminar list

Local and Global Regulation of Meiotic Prophase by Post-Translational Protein Modification

Neil Hunter.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 15 December 2014, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Using RNA-based approaches to identify and characterise cancer genes

Reuven Agami, Netherlands Cancer Institute, Amsterdam.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 11 December 2014, 13:00-14:00

Lectures in Cancer Biology

Tumour Metabolism

Christian Frezza, MRC Cancer Unit.

CRUK CI Lecture Theatre.

Thursday 11 December 2014, 09:30-10:30

MRC LMB Seminar list

Max Perutz Lecture 2014: C. elegans surveillance of conserved cellular components to detect and defend pathogen attacks, real or imagined

Gary Ruvkun, MGH Harvard.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 05 December 2014, 16:15-18:00

Lectures in Cancer Biology

Oncogenes and tumour suppressors (signalling and pathways)

Masashi Narita, Cancer Research UK Cambridge Institute.

CRUK CI Lecture Theatre.

Thursday 04 December 2014, 09:30-10:30

Cambridge Oncology Seminar Series

In vivo function-based genomic approaches for cancer drug target discovery

Hutchison/MRC Research Centre Seminar

Professor Daniel Peeper, Head, Division of Molecular Oncology, The Netherlands Cancer Institute.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 02 December 2014, 12:00-13:00

Gurdon Institute Seminar Series

A Protein phosphatase 1/protein phosphatase 2A relay controls mitotic progression

Iain Hagan, Cancer Research UK Manchester Institute.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 02 December 2014, 11:30-12:30

Lectures in Cancer Biology

Transcription

Jason Carroll, Cancer Research UK Cambridge Institute.

CRUK CI Lecture Theatre.

Thursday 27 November 2014, 09:30-10:30

Gurdon Institute Seminar Series

Evolution of Cell-Cell Adhesion, and New Insight into Mechanisms in Animals

W. James Nelson, Stanford, USA.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 25 November 2014, 11:30-12:30

Cancer Research UK Cambridge Institute Seminars in Cancer

The use of recent advances in electron microscopy to study the ribosome

Venki Ramakrishnan, MRC Laboratory of Molecular Biology.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 20 November 2014, 13:00-14:00

Lectures in Cancer Biology

Development and the cell cycle

Anna Philpott, Department of Oncology, MRC-Hutchison Research Centre.

CRUK CI Lecture Theatre.

Thursday 20 November 2014, 09:30-10:30

Cambridge Oncology Seminar Series

Cell fate in response to anti-mitotic chemotherapeutics

Hutchison/MRC Research Centre Seminar (please note unusual date)

Professor Stephen Taylor, Faculty of Life Sciences, University of Manchester.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Wednesday 19 November 2014, 12:00-13:00

Cambridge Oncology Seminar Series

Tracking genomic aberrations of the androgen receptor (AR) in castration-resistant prostate cancer (CRPC)

Host: Dr Simon Pacey

Dr Gerhardt Attard, Royal Marsden Hospital, London.

CRUK CI Lecture Theatre.

Tuesday 18 November 2014, 12:00-13:00

Cambridge Haematopoiesis Seminars

Mimicking of the process of human erythropoiesis using in vitro culture; studies on red blood cell membrane assembly and also use of 3D scaffolds

Dr Ashley Toye, University of Bristol.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 14 November 2014, 16:00-17:00

Lectures in Cancer Biology

Genetic instability - observation and concepts

Paul Edwards, Department of Pathology.

CRUK CI Lecture Theatre.

Thursday 13 November 2014, 09:30-10:30

Cambridge Oncology Seminar Series

“Stratified Medicine in Cancer Therapy - a practical guide”

Host: Dr Nitzan Rosenfeld

Professor Gary Middleton, Professor in Medical Oncology, School of Cancer Sciences, University of Birmingham.

CRUK CI Lecture Theatre.

Tuesday 11 November 2014, 12:00-13:00

MRC LMB Seminar list

The amazing hepatocyte: master of disguise and adaptation

Dr Markus Grompe.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 10 November 2014, 16:15-18:00

MRC LMB Seminar list

Genome stability and instability during repair of a broken chromosome

Jim Haber, Director, Rosenstiel Basic Medical Sciences Research Center.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 06 November 2014, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Whole-genome sequencing of cell-free DNA in maternal plasma

Dineika Chandrananda .

CRUK CI Lecture Theatre.

Monday 03 November 2014, 16:00-17:00

Lectures in Cancer Biology

Overview of cancer theoretical framework

Paul Edwards, Department of Pathology.

CRUK CI Lecture Theatre.

Thursday 30 October 2014, 09:30-10:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Targeting the brain tumour stem cell phenotype with small molecules

Heiko Wurdak (Leeds).

CRUK CI Lecture Theatre.

Monday 27 October 2014, 16:00-17:00

Cambridge Oncology Seminar Series

"The role of epigenetic regulators and their therapeutic targeting in Acute Myeloid Leukaemia and haematological malignancies”

Host: Professor Duncan Jodrell

Dr Brian Huntly, Department of Haematology, Cambridge University.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 21 October 2014, 12:00-13:00

Gurdon Institute Seminar Series

Microtubules need actin's help in large oocytes, to collect chromosomes and to break the nuclear envelope

Péter Lénárt, EMBL, Heidelberg.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 21 October 2014, 11:30-12:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Dissecting translation efficiency through lab evolution, genome engineering and inspection of the cancerous genome

Yitzhak Pilpel (Weizmann Institute, Israel).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 20 October 2014, 16:00-17:00

Cambridge Haematopoiesis Seminars

Hematopoietic stem cell formation in the embryo

Prof. Nancy Speck, University of Pennsylvania.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Thursday 16 October 2014, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

The role of dsRNA in cellular response to genetic change

Andrew Fire, Stanford University.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 16 October 2014, 13:00-14:00

Lectures in Cancer Biology

Tumour natural history, structure and nomenclature (lecture/demonstration)

Paul Edwards, Department of Pathology.

CRUK CI Lecture Theatre.

Thursday 16 October 2014, 09:30-10:30

Cambridge Oncology Seminar Series

CANCELLED - Lung cancer, biomarkers and unanswered questions - a clinical translational perspective

Host: Dr Simon Pacey

Dr Fiona Blackhall, Consultant Medical Oncologist, The Christie Hospital, Manchester .

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 14 October 2014, 12:00-13:00

Gurdon Institute Seminar Series

Self-organization of genetic oscillators during mouse mesoderm development

Alexander Aulehla, EMBL, Heidelberg.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 14 October 2014, 11:30-12:30

Cambridge Oncology Seminar Series

The role of stem cells in the pathogenesis of hepato-biliary cancers

Hutchison/MRC Research Centre Seminar

Professor Nisar Malek, University of Tubingen, Germany.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 07 October 2014, 12:00-13:00

Cambridge Oncology Seminar Series

“CDD’s new Research Strategy”

Host: Professor Duncan Jodrell

Dr Nigel Blackburn, Director of Centre for Drug Development, Cancer Research UK.

CRUK CI Lecture Theatre.

Tuesday 07 October 2014, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Modelling the transcriptional response to ER signalling in breast cancer cells

Magnus Rattray (Manchester).

CRUK CI Lecture Theatre.

Monday 06 October 2014, 16:00-17:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Discovery and allele frequency estimation of somatic twilight zone insertions and deletions

Alexander Schönhuth (CWI Amsterdam).

CRUK CI Lecture Theatre.

Monday 22 September 2014, 16:00-17:00

MRC LMB Seminar list

Crick Lecture 2014: How Aneuploidy Drives Cancer

Stephen Elledge, Gregor Mendel Professor of Genetics, Department of Genetics, Harvard Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 19 September 2014, 16:15-18:00

Cambridge Haematopoiesis Seminars

Clinical and Biological Impact of Flt3 mutations in Acute Leukaemia

Dr Adam Mead, University of Oxford.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 19 September 2014, 16:00-17:00

MRC LMB Seminar list

Feedback control of cell division

Andrea Musacchio, Director, Department of Mechanistic Cell Biology, Max-Planck Institute of Molecular Physiology .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 18 September 2014, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

The role of macrophages in tumour progression and metastasis

Jeffrey Pollard, University of Edinburgh and Albert Einstein College of Medicine, New York.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 18 September 2014, 13:00-14:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Therapeutic landscape of cancer drivers

Nuria Lopez-Bigas.

CRUK CI Lecture Theatre.

Monday 15 September 2014, 16:00-17:00

Cambridge Oncology Seminar Series

“Paradigm changes produced by targeted agents in Phase I trials in Oncology. Case studies of a TFbeta inhibitor and a Sonic Hedgehog inhibitor”

Host: Dr Richard Baird

Dr Jordi Rodon, Head of Research Unit for Molecular Therapy of Cancer Oncology Department. Vall D’Hebron University Hospital, Barcelona, Spain.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 09 September 2014, 12:00-13:00

Cambridge Haematopoiesis Seminars

Aurora A kinase and RPS14: new players in the myeloproliferative neoplasms

Prof. John Crispino, Northwestern University, Chicago.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Monday 08 September 2014, 16:00-17:00

MRC LMB Seminar list

From static structures to molecular movies: pushing the boundaries of X-ray Crystallography

Wei Yang, NIH, Bethesda, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 05 September 2014, 16:15-18:00

Cambridge Oncology Seminar Series

Cellular hierarchies in normal and malignant epithelial tissue

CRUK CI open seminar

John Stingl, Cancer Research UK Cambridge Institute.

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 28 July 2014, 14:45-15:45

MRC LMB Seminar list

The Consequences of Whole Genome Duplications

Prof David Pellman, Professor of Cell Biology, Harvard Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 22 July 2014, 16:15-18:00

Cambridge Oncology Seminar Series

'Scottish Collaboration On Translational Research into Renal Cell Cancer (SCOTRRCC): a springboard for renal cancer biomarker development’.

Host: Professor Tim Eisen

Mr Grant Stewart, Clinical Senior Lecturer and Honorary Consultant in Urological Surgery, University of Edinburgh .

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 22 July 2014, 12:00-13:00

MRC LMB Seminar list

Extrinsic regulation of haematopoietic stem cell self

Sean J. Morrison Investigator, Howard Hughes Medical Institute.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 15 July 2014, 11:45-13:30

Cambridge Haematopoiesis Seminars

Targeting survival pathways in CML stem cell persistence and TKI-resistance

Prof. Tessa Holyoake, University of Glasgow.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Monday 14 July 2014, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Whole-exome sequencing identifies recurrent functional mutations in melanoma

Yardena Samuels, The Weizmann Institute of Science, Israel.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 10 July 2014, 13:00-14:00

Cambridge Haematopoiesis Seminars

Dnmt3a in Normal and Malignant Hematopoiesis

Please note the different location of this seminar

Prof Margaret Goodell, Stem Cells and Regenerative Medicine Center, Baylor College of Medicine.

Clifford Allbutt Lecture Theatre, Clifford Allbutt Building (former LMB building).

Wednesday 09 July 2014, 13:00-14:00

Hutchison/MRC Research Centre Seminars

The Hippo Tumor Suppressor Network: Identifying New Therapeutic Targets

Host: Dr Anna Philpott

Professor Cathie Pfleger, Department of Oncological Sciences at the Icahn School of Medicine at Mount Sinai, USA.

L1 Meeting Rooms, Hutchison/MRC Research Centre, Addenbrooke's Campus.

Thursday 03 July 2014, 15:00-16:00

Cambridge Haematopoiesis Seminars

Normal and leukaemic (AML) human stem/progenitor cells

Prof. Paresh Vyas, WIMM, Oxford University.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Wednesday 02 July 2014, 16:15-17:15

MRC LMB Seminar list

Milstein Lecture 2014: Unfolded Protein Response in Health and Disease

Peter Walter, University of California, San Francisco .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 30 June 2014, 16:15-18:00

MRC LMB Seminar list

The function and execution of RTEL1 activities at vertebrate telomeres

Dr Simon Boulton, DNA damage Response Laboratory, London Research Institute.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 27 June 2014, 16:15-18:00

Cambridge Oncology Seminar Series

Noninvasive cancer genomics

CRUK CI seminar

Nitzan Rosenfeld, Cancer Research UK Cambridge Institute.

CRUK CI Lecture Theatre.

Friday 27 June 2014, 13:45-14:45

MRC LMB Seminar list

Exploring the final events in eukaryotic cell division

Juan Martin-Serrano, Kings College London.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 26 June 2014, 16:15-18:00

MRC LMB Seminar list

TBC

Juan Martin-Serrano.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 26 June 2014, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

*New speaker - replaces previously advertised seminar*

Ravid Straussman, Department of Molecular Cell Biology, Weizmann Institute of Science, Israel.

Cancer Research UK Cambridge Institute, Lecture Theatre.

Thursday 26 June 2014, 13:00-14:00

Lectures in Cancer Biology

Epigenetics and microRNA

This talk has been rescheduled from earlier in the year

Eric Miska, Wellcome Trust/Cancer Research UK Gurdon Institute.

CRUK-CI Lecture Theatre.

Thursday 26 June 2014, 09:30-10:30

Cambridge Oncology Seminar Series

Precision Cancer Prevention: Trying to use Genomics to Save Lives

Host: Dr Marc Tischkowitz

John Hopper, Professor & Director (Research), Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, University of Melbourne, Australia.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 24 June 2014, 12:00-13:00

Lectures in Cancer Biology

Epidemiology

Paul Pharoah, Department of Public Health and Primary Care.

CRUK CI Lecture Theatre.

Thursday 19 June 2014, 09:30-10:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

The Cancer Genome Atlas: oncogenic signature classes and the design of combinatorial therapy

Chris Sander (MSKCC).

CRUK CI Room 215.

Friday 13 June 2014, 12:00-13:00

Lectures in Cancer Biology

MRI and MRS in cancer research and treatment

John Griffiths, Cancer Research UK Cambridge Institute.

CRUK CI Lecture Theatre.

Thursday 12 June 2014, 09:30-10:30

Cambridge Oncology Seminar Series

Breast Imaging research in Cambridge

Host: Dr Richard Baird

Professor Fiona Gilbert, Head of Department of Radiology, Cambridge.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 10 June 2014, 12:00-13:00

Cambridge Haematopoiesis Seminars

Regulation of Akt by the Sin1-mTOR complex in lymphocytes

Prof. Bing Su (Department of Immunobiology at Yale, and Shanghai Institute of Immunology at Shanghai JiaoTong University School of Medicine).

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 06 June 2014, 16:00-17:00

Lectures in Cancer Biology

Radiotherapy

Neil Burnet, Department of Oncology.

CRUK CI Lecture Theatre.

Thursday 05 June 2014, 09:30-10:30

Cambridge Oncology Seminar Series

Undermining Myc: Mitochondria Hold the Key

Hutchison/MRC Research Centre Seminar

Dr Daniel Murphy, Institute of Cancer Sciences, University of Glasgow.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 03 June 2014, 12:00-13:00

Lectures in Cancer Biology

Metabolism, oxygen and cancer

John Griffiths, Cancer Research UK Cambridge Institute.

CRUK CI Lecture Theatre.

Thursday 29 May 2014, 09:30-10:30

Lectures in Cancer Biology

Drug discovery

Grahame McKenzie, MRC Cancer Unit.

CRUK CI Lecture Theatre.

Thursday 22 May 2014, 09:30-10:30

Cambridge Oncology Seminar Series

Personalised Cancer Medicine. How do we get there?

Host: Dr Jean Abraham

Dr Helena Earl, Dept. of Oncology, University of Cambridge.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 20 May 2014, 12:00-13:00

MRC LMB Seminar list

Engineering strategies for tuning cell surface receptor signalling

K. Christopher Garcia, Stanford University School of Medicine .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 14 May 2014, 16:15-18:00

Cambridge Haematopoiesis Seminars

Familial thrombocytopenias with predisposition to leukemia: RUNX1 targets

Dr Hana Raslova, Institut Gustave Roussy, Paris.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 13 May 2014, 16:00-17:00

Cambridge Oncology Seminar Series

"From trials evaluating drugs to trials evaluating treatment algorithms – Focus on the SHIVA trial"

Host: Dr Gill Barnett

Dr Christophe Le Tourneau, Medical Oncologist, Head of the Phase I Program at the Institut Curie, Paris, France,.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 13 May 2014, 12:00-13:00

Lectures in Cancer Biology

Therapeutics and clinical trials

Duncan Jodrell, Cancer Research UK Cambridge Institute.

CRUK CI Lecture Theatre.

Thursday 08 May 2014, 09:30-10:30

Cancer Research UK Cambridge Institute Seminars in Cancer

TALK CANCELLED

Talk cancelled, apologies.

Joan S Brugge, Harvard Medical School, Cambridge.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Tuesday 06 May 2014, 13:00-14:00

Cambridge Oncology Seminar Series

Spatio-temporal control of RhoGTPases and the cytoskeleton in invading cancer cells by integrins and endocytic trafficking

Hutchison/MRC Research Centre Seminar

Dr Patrick Caswell, Wellcome Trust Centre for Cell-Matrix Research, University of Manchester.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 06 May 2014, 12:00-13:00

Lectures in Cancer Biology

Signal transduction

Ian Mills, Centre for Molecular Medicine Norway.

CRUK CI Lecture Theatre.

Thursday 01 May 2014, 09:30-10:30

MRC LMB Seminar list

Structural basis of protein PARylation-dependent ubiquitination

Rachel Klevit, University of Washington.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 24 April 2014, 16:15-18:00

Cambridge Haematopoiesis Seminars

Engaging mechanisms of negative B cell selection to overcome drug-resistance in leukaemia

Prof. Markus Müschen, UCSF.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 22 April 2014, 15:00-16:00

MRC LMB Seminar list

Francis Crick Lecture 2014: Prions Causing Neurodegeneration: A Unifying Etiology and the Quest for Therapeutics

Stanley Prusiner, University of California San Francisco .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 11 April 2014, 15:00-17:00

MRC LMB Seminar list

What can NMR tell us about how a virus enters its host cell?

Ad Bax, NIH.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 10 April 2014, 11:00-12:00

Lectures in Cancer Biology

**Postponed to 22 May** Drug discovery

This talk has been postponed until 22 May

Grahame McKenzie, MRC Cancer Unit.

CRUK CI Lecture Theatre.

Thursday 10 April 2014, 09:30-10:30

Cambridge Oncology Seminar Series

Centrosome changes in cancer – causes and consequences

CRUK CI guest seminar

Monica Bettencourt Dias, Instituto Gulbenkian de Ciência.

CRUK CI Lecture Theatre.

Wednesday 09 April 2014, 11:00-12:00

Cambridge Oncology Seminar Series

Targeting bioenergetics in hypoxic and rapidly growing tumours

Hutchison/MRC Research Centre Seminar

Dr Jacques Pouysseggur, Institute of Research on Cancer and Ageing (IRCAN), Nice, France.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 08 April 2014, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Variations in genetic and phenotypic diversity during breast cancer progression.

Vanessa Almendro (Harvard University).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 07 April 2014, 16:00-17:00

Cambridge Haematopoiesis Seminars

Neuroendocrine regulation of the bone marrow stem-cell niche

Simón Méndez-Ferrer, CNIC, Madrid, Spain.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 04 April 2014, 16:00-17:00

Lectures in Cancer Biology

**Postponed to 19 June** Epidemiology

Postponed to 19 June

Paul Pharoah, Department of Public Health and Primary Care.

CRUK CI Lecture Theatre.

Thursday 03 April 2014, 09:30-10:30

Cambridge Oncology Seminar Series

“Personalized Medicine in Oncology: The Dutch experience”

Host: Dr Richard Baird

Professor Jaap Verweij, Erasmus MC Cancer Institute, Weytemaweg 80, 3105 CN Rotterdam, The Netherlands.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 01 April 2014, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Single molecule approaches for studying gene expression in intact mammalian tissues.

Shalev Itzkovitz (Weizmann Institute).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 31 March 2014, 16:00-17:00

MRC LMB Seminar list

Building proteins de novo: better, faster, fitter

Dek Woolfson, University of Bristol.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 27 March 2014, 16:15-18:00

MRC LMB Seminar list

John Kendrew Lecture 2014: Birth and Future of Multi-Scale Modeling of Macromolecules

Michael Levitt, Standford Unversity.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 25 March 2014, 16:15-18:00

Gurdon Institute Seminar Series

Generating neuronal diversity: stochastic or deterministic choices

Claude Desplan, Department of Biology, New York University, USA.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 25 March 2014, 11:00-12:00

MRC LMB Seminar list

microRNAs, circular RNAs, and micropeptides

Professor Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine, Berlin.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 24 March 2014, 15:00-16:15

Cambridge Haematopoiesis Seminars

Heterogeneity of hematopoietic stem and progenitor cell populations: implications for ageing and regeneration

Claus Nerlov, University of Oxford.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 21 March 2014, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Clinical Systems Medicine in Acute Myeloid Leukemia and Beyond

Olli Kallioniemi, Institute for Molecular Medicine Finland.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 20 March 2014, 13:00-14:00

Lectures in Cancer Biology

In vivo models

Suzanne Turner, Department of Pathology.

CRUK-CI Lecture Theatre.

Thursday 20 March 2014, 09:30-10:30

Cancer Research UK Cambridge Institute seminars

**CANCELLED** The role of EGFR family receptor signaling-induced NF-kB activation in human breast cancer

Debajit Biswas, Dana-Farber Cancer Institute and Harvard Medical School.

Cancer Research UK Cambridge Research Institute, Room 215.

Wednesday 19 March 2014, 15:00-16:00

Cancer Research UK Cambridge Institute seminars

Targeted Cancer Therapy: Accomplishments and Challenges

John Mendelsohn, MD Anderson Cancer Center Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy.

Cancer Research UK Cambridge Institute, Lecture Theatre.

Wednesday 19 March 2014, 13:00-14:00

Cambridge Haematopoiesis Seminars

Of mice and men and Tasmanian devils; assembling reference genomes from single cells.

Dr Mark Hills, Terry Fox Lab, Vancouver, Canada.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 14 March 2014, 11:00-12:00

Lectures in Cancer Biology

Genomic technologies

Jason Carroll, Cancer Research UK Cambridge Institute.

CRUK-CI Lecture Theatre.

Thursday 13 March 2014, 09:30-10:30

Gurdon Institute Seminar Series

Origins and consequences of (epi)genetic variation in Arabidopsis thaliana and its relatives

Detlef Weigel, Max Planck Institute for Developmental Biology, Tübingen, Germany.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 11 March 2014, 11:00-12:00

Cambridge Haematopoiesis Seminars

Notch and Wnt Signaling: From Hematopoeitic Stem Cells to Leukemia

Anna Bigas. Cancer and Stem Cells Research Group. Institut Hospital del Mar d'Investigacions Mèdiques (IMIM).

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 07 March 2014, 13:00-14:00

Lectures in Cancer Biology

Solid vs. non-solid tumours

Please note change of room, we will meet external attendees in reception and accompany them to the seminar room.

Brian Huntly, Department of Haematology.

CRUK CI Room 215.

Thursday 06 March 2014, 09:30-10:30

Cambridge Oncology Seminar Series

Cell death and autophagy in response to inhibition of glycolysis

Hutchison/MRC Research Centre Seminar

Dr Cristina Muñoz Pinedo, IDIBELL, Barcelona, Spain.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 04 March 2014, 12:00-13:00

MRC Cancer Unit Seminars

Molecular DNA Devices in Living Systems

Dr Yamuna Krishnan, National Centre for Biological Sciences, TIFR, Bangalore, India.

Sackler Lecture Theatre, CIMR, Level 7.

Thursday 27 February 2014, 15:00-16:00

Lectures in Cancer Biology

Computational biology

Please note change of room, we will meet external attendees in reception and accompany them to the seminar room.

Florian Markowetz, Cancer Research UK Cambridge Institute.

CRUK CI Room 215.

Thursday 27 February 2014, 09:30-10:30

MRC LMB Seminar list

Type VI Secretion System: structure, function and dynamics of a multicomponent nanomachine that is evolutionarily related to a contractile phage tail

Marek Basler, University of Basel.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 26 February 2014, 16:15-18:00

Research Seminars - Department of Biochemistry

Shedding light on cytoskeletal mRNA transport in vivo and in vitro

Simon Bullock, MRC-LMB, Cambridge.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 25 February 2014, 13:00-14:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

The Resistant Cancer Cell Line (RCCL) collection – cancer cell lines with acquired drug resistance as a pre-clinical and basic science model

Martin Michaelis (University of Kent).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 17 February 2014, 16:00-17:00

Lectures in Cancer Biology

Transcriptional regulation and techniques

Please note this talk is on a Wednesday

Duncan Odom, Cancer Research UK Cambridge Institute.

CRUK-CI Lecture Theatre.

Wednesday 12 February 2014, 09:30-10:30

Cambridge Oncology Seminar Series

“What can we do to accelerate the discovery of new medicines for patients?”

Host: Dr Bristi Basu

Professor Chas Bountra, Head of Structural Genomics Consortium, University of Oxford, Nuffield Dept of Clinical Medicine .

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 11 February 2014, 12:00-13:00

Gurdon Institute Seminar Series

Mechanisms of centriole assembly

Pierre Gönczy, EPFL, Lausanne, Switzerland.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 11 February 2014, 11:00-12:00

MRC LMB Seminar list

Lighting up RNA Interactions in Living Cells

David Tollervey, WTCCB, University of Edinburgh.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 10 February 2014, 14:00-15:00

Cambridge Haematopoiesis Seminars

4D tracking of haematopoietic stem and progenitor cells in their bone marrow microenvironment

Dr Cristina Lo Celso, Imperial College London.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 07 February 2014, 16:00-17:00

Lectures in Cancer Biology

Circulating DNA and diagnostics

Nitzan Rosenfeld, Cancer Research UK Cambridge Institute.

CRUK-CI Lecture Theatre.

Thursday 06 February 2014, 09:30-10:30

Research Seminars - Department of Biochemistry

The dinucleotide CpG as a genomic signalling module

Adrian Bird, Wellcome Trust Centre for Cell Biology, University of Edinburgh, UK.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 04 February 2014, 13:00-14:00

Cambridge Oncology Seminar Series

Translating Tumour Metabolism into New Diagnostics and Novel Anti-Cancer Therapeutics

Hutchison/MRC Research Centre Seminar

Professor Michael Lisanti, Director of the Breakthrough Breast Cancer Research Unit, University of Manchester.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 04 February 2014, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Using time-resolved genetic data to study the evolution of drug resistance.

Ville Mustonen (Sanger Institute).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 03 February 2014, 16:00-17:00

Research Seminars - Department of Biochemistry

Tube formation during C. elegans vulval development: Linking cell fate with morphogenesis

Alex Hajnal, Institute of Molecular Life Sciences, University of Zurich, Switzerland.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 28 January 2014, 13:00-14:00

Gurdon Institute Seminar Series

Cell shape and morphogenesis: sub cellular and supra-cellular mechanisms

The Anne McLaren Lecture

Maria Leptin, EMBO, Heidelberg, Germany.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 28 January 2014, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Profiling the Subclonal Copy Number Architecture from Whole Genome Sequencing of Heterogeneous Tumours

Gavin Ha, BC Cancer Research Centre.

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 27 January 2014, 16:00-17:00

MRC LMB Seminar list

Feldberg Prize Lecture: The mitochondrial machinery for transport and assembly of proteins

Klaus Pfanner, University of Freiburg.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 23 January 2014, 16:15-18:00

Research Seminars - Department of Biochemistry

Structure, function and mechanisms of dynamin-superfamily proteins

Oliver Daumke, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 21 January 2014, 13:00-14:00

Gurdon Institute Seminar Series

Stem cell dynamics during development, homeostasis and cancer

Cédric Blanpain, WELBIO, Interdisciplinary Research Institute (IRIBHM), Université Libre de Bruxelles, Belgium.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 21 January 2014, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Systems biology of stem cell fate

Ben MacArthur (University of Southampton).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 20 January 2014, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

NextGen Research: Enabling distributed teams of experts and the engaged public to solve complex biomedical problems

Stephen Friend, Sage Bionetworks, Seattle.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 16 January 2014, 13:00-14:00

Cambridge Oncology Seminar Series

Personalized medicine initiative at Gustave Roussy

Host: Dr Richard Baird

Professor Jean-Charles SORIA - Chef de Service, Professor of Medicine and Medical Oncology, Paris University XI and cancer specialist at Institut Gustave, Roussy..

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 14 January 2014, 12:00-13:00

MRC LMB Seminar list

Systematic cell biology - Moving beyond text-book schemes

Maya Schuldiner, The Weizmann Insitute of Science.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 09 January 2014, 14:00-15:00

Cambridge Haematopoiesis Seminars

Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology

Bengt Hallberg (Umea University, Sweden).

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 07 January 2014, 16:00-17:00

Cambridge Oncology Seminar Series

Chasing metabolic alterations in cancer

Hutchison/MRC Research Centre Seminar

Dr Arkaitz Carracedo, CIC bioGUNE, (Center for Cooperative Research in Biosciences), Derio, Spain.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 07 January 2014, 12:00-13:00

Cambridge Oncology Seminar Series

CANCELLED

Host: Dr Richard Baird

Prof Josep Tabernero, Head, Medical Oncology Department, Vall d' Hebron University Hospital, Barcelona, Spain.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 17 December 2013, 12:00-13:00

Cancer Research UK Cambridge Institute seminars

Detecting low-concentration compounds with water sensitivity and spectroscopic specificity using CEST-MRI

Peter van Zijl, Johns Hopkins University and Kennedy Krieger Institute.

Cancer Research UK Cambridge Institute, Lecture Theatre.

Friday 13 December 2013, 13:00-14:00

MRC LMB Seminar list

GPCRs: From thermostabilisation to X-ray structures and Drug discovery

Fiona Marshall, Heptares Therapeutics.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 12 December 2013, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Harnessing Genetic Dependencies in Cancer Therapy

Alan Ashworth, The Institute of Cancer Research, London.

Cancer Research UK Cambridge Institute, Lecture Theatre.

Thursday 12 December 2013, 13:00-14:00

Lectures in Cancer Biology

Metastasis

Gill Murphy, Cancer Research UK Cambridge Institute.

CRUK-CI Lecture Theatre.

Thursday 12 December 2013, 09:30-10:30

Cancer Research UK Cambridge Institute seminars

Comprehensive transcriptome and epigenome sequencing of hypoxic breast cancer reveals non-coding RNAs associated with clinicopathological features

Ioannis (Jiannis) Ragoussis, McGill University, Canada and Genome Quebec Innovation Centre.

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 09 December 2013, 13:00-14:00

MRC Cancer Unit Seminars

Competition between adaptor protein and phospholipase regulates metastatic outcome

Prof John E. Ladbury, Edward Rotan Distinguished Professor in Cancer Research & Director of the Center for Biomolecular Structure and Function, MD Anderson Cancer Center.

Sackler Lecture Theatre, CIMR, Level 7.

Friday 06 December 2013, 15:00-16:00

Lectures in Cancer Biology

Tumour metabolism

Christian Frezza, MRC Cancer Unit.

CRUK-CI Lecture Theatre.

Thursday 05 December 2013, 09:30-10:30

Cambridge Oncology Seminar Series

The autophagy signaling network in the coordination of a cell's response

Hutchison/MRC Research Centre Seminar

Prof Francesco Cecconi, University of Tor Vergata, Italy .

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 03 December 2013, 12:00-13:00

Gurdon Institute Seminar Series

Bending the not so simple mind of the fruit fly

Scott Waddell, Centre for Neural Circuits and Behaviour, University of Oxford.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 03 December 2013, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Incorporating Prior Biological Knowledge into Genetic Association Studies

David V. Conti (USC).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 02 December 2013, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Hallmarks of Cancer: Applications to Cancer Medicine?

Douglas Hanahan, Swiss Institute for Experimental Cancer Research.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 28 November 2013, 13:00-14:00

Cambridge Oncology Seminar Series

"The Cambridge Breast Cancer Programme"

Host: Dr Richard Baird

Prof Carlos Caldas, CRUK Cambridge Research Institute.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 26 November 2013, 12:00-13:00

Cambridge Haematopoiesis Seminars

Cancer Epigenetics: Appreciating the beauty and complexity of a string of pearls

Mark Dawson, University of Cambridge.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 22 November 2013, 16:00-17:00

Lectures in Cancer Biology

Stem cells and cancer

Phil Jones, MRC Cancer Unit.

CRUK-CI Lecture Theatre.

Thursday 21 November 2013, 09:30-10:30

Gurdon Institute Seminar Series

Growth and size regulation in development and disease

Tian Xu, HHMI/Yale University, USA.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 19 November 2013, 11:00-12:00

Lectures in Cancer Biology

Introduction to cancer in Cambridge (BP) followed by Cell cycle and checkpoints (AP)

Bruce Ponder and Anna Philpott, Department of Oncology.

CRUK-CI Lecture Theatre.

Thursday 14 November 2013, 09:30-10:30

Research Seminars - Department of Biochemistry

Towards an RNA structure of everything

Kevin Weeks, Department of Chemistry, University of North Carolina, Chapel Hill.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 12 November 2013, 13:00-14:00

Cambridge Haematopoiesis Seminars

Haematopoietic Stem Cells

Prof. Connie Eaves, Terry Fox Laboratory, Vancouver.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 12 November 2013, 12:30-13:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Measuring within-tumour diversity as a universal biomarker for cancer prognosis

Trevor Graham (Barts Cancer Institute, Queen Mary Univ London).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 11 November 2013, 16:00-17:00

Cambridge Haematopoiesis Seminars

Emerging therapeutic strategies for treating the first molecular disease

Prof. James Douglas Engel, University of Michigan Medical School, USA.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 08 November 2013, 16:00-17:00

MRC LMB Seminar list

Brain Power: Where does it come from and how is it used?

Professor David Attwell, University College London.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 07 November 2013, 17:00-18:00

Research Seminars - Department of Biochemistry

Regulation of pre-mRNA splicing fidelity by the Nineteen Complex

Raymond O'keefe, Faculty of Life Sciences, University of Manchester.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 05 November 2013, 13:00-14:00

Gurdon Institute Seminar Series

Self-regulatory mechanism of multicellular systems: tissue self-organization and scaling

Yoshiki Sasai, RIKEN Center for Developmental Biology, Kobe, Japan.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 05 November 2013, 11:00-12:00

MRC Cancer Unit Annual Lecture

The p53 pathway: 21 years of the "guardian of the genome"

Refreshments will be available after this talk outside the lecture theatre

Prof Sir David Lane, Chief Scientist, A*STAR, Singapore.

Max Perutz Lecture Theatre, MRC Laboratory of Molecular Biology.

Monday 04 November 2013, 16:00-17:30

MRC LMB Seminar list

John Kendrew Lecture 2013: Noncoding RNAs: with a viral twist

Joan Steitz, Yale University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 01 November 2013, 16:15-18:00

MRC LMB Seminar list

Embracing Complexity: A Drosophila Approach To Cancer Therapeutics

Ross Cagan, Mt. Sinai School of Medicine.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 31 October 2013, 16:15-18:00

Research Seminars - Department of Biochemistry

The biochemistry & genetics of bacterial predation by Bdellovibrio bacteriovorus

Liz Sockett, School of Biology, University of Nottingham.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 29 October 2013, 13:00-14:00

Cambridge Oncology Seminar Series

CANCELLED - Scottish Collaboration On Translational Research into Renal Cell Cancer, developing a systems medicine approach to personalised treatment

Mr Grant Stewart, Department of Urology and Edinburgh Urological Cancer Group,Western General Hospital. Edinburgh.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 29 October 2013, 12:00-13:00

Research Seminars - Department of Biochemistry

Quantitative Analysis of Transcriptomes and Proteomes in Proliferating and Quiescent Cells

Jürg Bähler, Department of Genetics, Evolution & Environment, UCL.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 22 October 2013, 13:00-14:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Analysis of a large cancer gene screen in myelodysplastic syndromes

Moritz Gerstung (Sanger).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 21 October 2013, 16:00-17:00

Cambridge Haematopoiesis Seminars

Bone marrow environment and platelet production

Assoc. Prof. Alessandra Balduini, University of Pavia Italy, and Tufts University USA.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 18 October 2013, 16:00-17:00

Lectures in Cancer Biology

Development

Anna Philpott, Department of Oncology.

CRUK-CI Lecture Theatre.

Thursday 17 October 2013, 09:30-10:30

Cambridge Haematopoiesis Seminars

Mutations in Epigenetic Modifiers in Myeloid Malignancies

Dr Ross Levine, Memorial Sloan-Kettering Cancer Center, New York.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 15 October 2013, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Chromatin and its Impact on Gene Expression and Cellular Memory

Please note that this talk is on a Tuesday

Danny Reinberg, Howard Hughes Medical Institute, NYU School of Medicine.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Tuesday 15 October 2013, 13:00-14:00

Research Seminars - Department of Biochemistry

Thrombospondins, Matrix and the Emerging Role of Fascin-1 in Carcinoma Metastasis

Josephine C. Adams, School of Biochemistry, Bristol.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 15 October 2013, 13:00-14:00

Gurdon Institute Seminar Series

Mechanisms of cellular programming and reprogramming

Ken Zaret, University of Pennsylvania, USA.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 15 October 2013, 11:45-12:45

MRC LMB Seminar list

Can structural studies of intact viruses really be useful in the search for better vaccines and antivirals?

David Stuart, University of Oxford.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 10 October 2013, 16:15-18:00

Cambridge Oncology Seminar Series

Spotlight on Cambridge Clinical Trials; Presentations from the American Society of Oncology (ASCO) Annual Meeting 2013

Host: Dr Simon Pacey

Prof Tim Eisen, Dr Hugo Ford, Dr Pippa Corrie & Dr Kate Fife.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 08 October 2013, 12:00-13:00

Cambridge Haematopoiesis Seminars

Forward genetic screening using patient CML cells identifies IKAROS as a myeloid tumour suppressor

Dr Philip Beer, Terry Fox Laboratory, Vancouver.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Monday 07 October 2013, 17:00-18:00

Cancer Research UK Cambridge Institute seminars

Tumor hypoxia: developing prognostic biomarkers to predict therapeutic outcome

Ralph P. Mason, The University of Texas Southwestern Medical Center.

Cancer Research UK Cambridge Institute, Lecture Theatre.

Friday 04 October 2013, 13:00-14:00

MRC LMB Seminar list

Conformational Conversion in Amyloid Assembly

Sheena Radford, University of Leeds.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 03 October 2013, 16:15-18:00

Cambridge Oncology Seminar Series

Target-Based Approach in Early-Phase Clinical Trials in Cancer

Host: Dr Richard Baird

Filip Janku, Investigational Cancer Therapeutics, (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 01 October 2013, 12:00-13:00

MRC LMB Seminar list

Milstein Lecture 2013: Sorting out protein traffic: Ubiquitin-mediated endocytosis and a membrane protien’s final ESCRT

Scott Emr, Cornell University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 26 September 2013, 16:15-18:00

MRC LMB Seminar list

Innate Immune Sensing and Signaling of Cytosolic DNA and RNA

Zhijan 'James' Chen, University of Texas Southwestern Medical Center.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 24 September 2013, 16:15-18:00

Cambridge Oncology Seminar Series

CANCELLED

Professor Charles Swanton, CRUK & UCL Trials Centre, UCL.

CRI Lecture Theatre.

Tuesday 24 September 2013, 12:00-13:00

Cambridge Haematopoiesis Seminars

Molecular and cellular basis of disease initiation in myeloproliferative neoplasms

Prof. Radek Skoda, Head of the Department of Biomedicine, University Hospital, Basel.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 20 September 2013, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Inflammation and Cancer: Reprogramming the immune microenvironment as an anti-cancer therapeutic strategy

Lisa M. Coussens. Department of Cell & Developmental Biology, Knight Cancer Institute, Oregon Health & Sciences University.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 19 September 2013, 13:00-14:00

Cambridge Haematopoiesis Seminars

Look Beyond the Target: How Lessons from Chronic Myeloid Leukaemia Can Improve Cancer Targeted Therapies

Assoc. Prof. Sin Tiong Ong, Duke-NUS Graduate Medical School Singapore & Duke University Medical Center.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Wednesday 18 September 2013, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Colon CSCs are sensitized by HDACinhibitors in a FOXO-dependent fashion

Jan Paul Medema (Amsterdam Medical Center).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 16 September 2013, 16:00-17:00

Cambridge Oncology Seminar Series

Advances in non-surgical treatment for cervix cancer

Dr Li Tee Tan, Addenbrooke's .

CRI Lecture Theatre.

Tuesday 10 September 2013, 12:00-13:00

MRC LMB Seminar list

Long-distance organelle transport in the neuron: mechanisms of motor engagement and motor coordination

Erika Holzbaur, University of Pennyslvania.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 05 September 2013, 16:15-18:00

MRC LMB Seminar list

The Evolutionary 'Design' of Proteins

Rama Ranganathan, UT Southwestern Medical Centre.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 04 September 2013, 11:00-12:00

Cambridge Oncology Seminar Series

Insights for the role of tumour-related inflammation and stem cells in Drosophila

Hutchison/MRC Research Centre Seminar

Dr Marcos Vidal, Beatson Institute, Glasgow .

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 03 September 2013, 12:00-13:00

MRC Cancer Unit Seminars

Asian Cancer Genomics and its Clinical Implications

Professor Bin Tean Teh, National Cancer Centre Singapore (NCCS)-VARI Laboratory .

Sackler Lecture Theatre, CIMR, Level 7.

Friday 23 August 2013, 11:00-12:00

MRC LMB Seminar list

Watching Individual Proteins Working on Single Molecules of DNA: from Biophysics to Cancer

Steve Kowalczykowski, University of California.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 09 August 2013, 16:15-18:00

Hutchison/MRC Research Centre Seminars

Regulation of p53-dependent gene expression in vivo

Prof James J. Manfredi, Department of Oncological Sciences, Mount Sinai School of Medicine, USA.

L1 Meeting Rooms, Hutchison/MRC Research Centre, Addenbrooke's Campus.

Tuesday 06 August 2013, 15:00-16:00

MRC LMB Seminar list

Biological insights from cryo-EM studies of complex macromolecular assemblies in transcription initiation and microtubule dynamics

Eva Nogales, HHMI University of California Berkely.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 24 July 2013, 16:15-18:00

Hutchison/MRC Research Centre Seminars

CD66+/Notch high cells in human cervical tumours: linking papillomavirus life cycle to cancer progression

Professor Sudhir Krishna, National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.

Sackler Lecture Theatre, CIMR, Level 7.

Thursday 18 July 2013, 15:00-16:00

Cancer Research UK Cambridge Institute Seminars in Cancer

HER2 and EGFR: Signalling mechanisms and next generation cancer therapies

Yosef Yarden, Weizmann Institute of Science, Israel.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 18 July 2013, 13:00-14:00

Cambridge Oncology Seminar Series

Risk and uncertainty in radiotherapy. Why I am the weakest link?

Dr Tom Roques, Lead of Head and Neck Cancer Multidisciplinary Team, Norfolk and Norwich Hospital.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 16 July 2013, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Platinum Genomes

Michael Eberle (Illumina).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Thursday 04 July 2013, 16:00-17:00

Cambridge Oncology Seminar Series

Genetic modifiers and microenvironmental control of tumor invasiveness

Hutchison/MRC Research Centre Seminar- Please note unusual time and 1:00pm start

Prof Douglas Hanahan, EPFL, Switzerland .

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 02 July 2013, 13:00-14:00

MRC LMB Seminar list

The impact of systemic inflammation on the brain in health and disease

Hugh Perry, University of Southampton.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 27 June 2013, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer

Note unusual day and time!

Stefan Wiemann (DKFZ Heidelberg).

Cancer Research UK Cambridge Institute, Room 009.

Tuesday 25 June 2013, 17:00-18:00

Cambridge Oncology Seminar Series

"Image guidance – benefits and risks"

Professor Marcel van Herk, Imaging Physicist, Project Leader, The Netherlands Cancer Institute.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 25 June 2013, 12:00-13:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Duplicating the Human genome: The Origin Recognition Complex et al

Bruce Stillman, FAA, FRS - Cold Spring Harbour Laboratory, New York.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 20 June 2013, 13:00-14:00

MRC LMB Seminar list

Intrinsic biophysical diversity and connectivity of neuronal circuits

Troy Margrie, NIMR.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 11 June 2013, 17:00-18:00

Cambridge Oncology Seminar Series

Economics of Cancer Medicines

Professor Richard Sullivan, Guy's Hospital, London.

CRI Lecture Theatre.

Tuesday 11 June 2013, 12:00-13:00

MRC LMB Seminar list

Direct Selection for Antibodies that Control Cell Fates from Intracellular Combinatorial Antibody Libraries

Professor Richard Lerner, The Scripps Research Institute, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 05 June 2013, 12:00-13:00

Cambridge Oncology Seminar Series

Control of cytokinesis and the dark side of actomyosin forces

Hutchison/MRC Research Centre Seminar

Dr Mark Petronczki, London Research Institute.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 04 June 2013, 12:00-13:00

MRC Cancer Unit Seminars

Stem cell dynamics in the pancreas

Prof Christopher Heeschen, CNIO, Spain.

Sackler Lecture Theatre, CIMR, Level 7.

Thursday 30 May 2013, 14:30-15:30

Cambridge Oncology Seminar Series

"Renal Cancer and Oxygen Sensing"

Prof Patrick Maxwell, Regius Professor of Physic, University of Cambridge.

CRI Lecture Theatre.

Tuesday 28 May 2013, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Petri nets as semi-quantitative modeling method to explore systems behavior of disease-related pathways

Ina Koch (Frankfurt University).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 20 May 2013, 16:00-17:00

Cancer Research UK Cambridge Institute seminars

SMARTer cDNA Synthesis for Illumina Sequencing and iDimerize Inducible Dimerization Systems

Syed Abedi, Takara-Clontech.

Cancer Research UK Cambridge Institute, Lecture Theatre.

Thursday 16 May 2013, 10:30-12:00

Cambridge Oncology Seminar Series

‘CLL – from chemotherapy to targeted kinase inhibition’

Buffet Lunch will be provided by courtesy of Chugai Pharma UK Ltd.

Dr George Follows, Consultant Haematologist, Addenbrooke's .

CRI Lecture Theatre.

Tuesday 14 May 2013, 12:00-13:00

MRC LMB Seminar list

Cytoskeletal Control of Leukocyte Chemotaxis

Michael Sixt, IST Austria.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 13 May 2013, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Genome-wide association studies: Lessons from studying a large clinical cohort

Sven Bergmann (Lausanne).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 13 May 2013, 16:00-17:00

Cambridge Oncology Seminar Series

Macrophages Into Tumor Hypoxic Areas: Should I Stay Or Should I Go?

Hutchison/MRC Research Centre Seminar

Dr Massimiliano Mazzone, VIB Vesalius Research Center, Belgium.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 07 May 2013, 12:00-13:00

Cambridge Haematopoiesis Seminars

Polycomb-mediated selfrenewal of young (and aged?) hematopoietic stem cells

Gerald de Haan, Scientific Co-Director, European Research Institute for the Biology of Ageing.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 03 May 2013, 11:00-12:00

MRC LMB Seminar list

Selective autophagy: when being picky pays of

Ana-Maria Cuervo, Albert Einstein College of Medicine .

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 02 May 2013, 16:15-18:00

MRC LMB Seminar list

Max Perutz Lecture: Five ways that viruses use to enter the animal cell

Professor Ari Helenius, ETH Zurich, Switzerland.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 30 April 2013, 14:30-15:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Mapping tumor heterogeneity and developmental trajectories using 40 markers at single cell resolution:

Room change: 215 instead of lecture theatre (outside guests will need visitor ID)

Dana Pe'er (Columbia University, NYC).

Cancer Research UK Cambridge Research Institute, Room 215.

Monday 29 April 2013, 16:00-17:00

Cambridge Oncology Seminar Series

“The identification of patients who benefit from targeted therapy in renal cancer”

(The lunch will be provided by courtesy of Pfizer)

Professor Thomas Powles, Barts Cancer Institute, Queen Mary University of London.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 23 April 2013, 12:00-13:00

Cancer Research UK Cambridge Institute Seminars in Cancer

The impact of cohesin on the regulation of gene expression and the organization of chromatin

Matthias Merkenschlager, Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London.

Cancer Research UK Cambridge Institute, Lecture Theatre.

Thursday 18 April 2013, 13:00-14:00

MRC LMB Seminar list

Machinery for making coated vesicles

Margaret Scott Robinson, CIMR.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 16 April 2013, 16:15-18:00

Cancer Research UK Cambridge Institute seminars

Standardising tumour tissue dissociation to increase the reliability and reproducibility of downstream analysis

Dawn Farrar, Miltenyi Biotec.

Cancer Research UK Cambridge Institute, Lecture Theatre.

Wednesday 10 April 2013, 11:00-12:00

MRC LMB Seminar list

The genetics of individuals: why would a mutation kill me, but not you?

Ben Lehner, CRG Barcelona.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 09 April 2013, 15:00-16:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Impact of cancer- and stroma-cell-derived lysosomal proteases on cancer invasion and metastasis

Thomas Reinheckel, University of Freiburg.

Cancer Research UK Cambridge Institute, Lecture Theatre.

Thursday 28 March 2013, 13:00-14:00

MRC LMB Seminar list

The mammalian circadian timing system: how the brain communicates with the periphery

Ueli Schibler, University of Geneva.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 27 March 2013, 12:00-13:00

Lectures in Cancer Biology

Computational biology

Florian Markowetz, Cancer Research UK Cambridge Research Institute.

CRI Lecture Theatre.

Thursday 21 March 2013, 09:30-10:30

Gurdon Institute Seminar Series

Spatial and temporal regulation of the DNA damage response

Jiri Lukas, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 19 March 2013, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Inferring causal mediators from omics data in the context of genetic and environmental variations

Oliver Stegle (EBI).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 18 March 2013, 16:00-17:00

Cancer Research UK Cambridge Institute seminars

New tools for NGS libraries: Long-Span, Mate-Pair Scaffolding and Methods for Faster Library Creation

Places are limited, please e-mail saphsa.codling@cruk.cam.ac.uk if you want to attend

David Mead, Founder and Chief Executive Officer of Lucigen .

CRUK Cambridge Institute Room 215.

Wednesday 13 March 2013, 12:30-13:30

Research Seminars - Department of Biochemistry

Drugging the cancer genome

Paul Workman, Institute of Cancer Research, Sutton, Surrey.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 12 March 2013, 13:00-14:00

Cambridge Oncology Seminar Series

CANCELLED

Dr Fiona Blackhall, Manchester University, Manchester Cancer Research Centre Lung Group Lead.

CRI Lecture Theatre.

Tuesday 12 March 2013, 12:00-13:00

MRC Cancer Unit Seminars

Deciphering mechanisms regulating cell growth and homeostasis with genome-scale in silico models

Dr Nathan Lewis, Harvard Medical School.

Sackler Lecture Theatre, CIMR, Level 7.

Monday 11 March 2013, 14:30-15:30

Lectures in Cancer Biology

Epigenetic cancer conspirators: DNA methylation, non-coding RNA and chromatin loops

This is an open seminar, all are welcome to attend

Adele Murrell, CRUK Cambridge Institute.

CRUK-CI Lecture Theatre.

Thursday 07 March 2013, 09:45-10:45

Gurdon Institute Seminar Series

Mechanisms of Wnt signal transduction

Christof Niehrs, Institute of Molecular Biology (IMB), Mainz, Germany.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 05 March 2013, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

The logic and variation in genomic regulatory networks

Mikhail Spivakov (Babraham Institute).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 04 March 2013, 16:00-17:00

MRC Cancer Unit Seminars

Deconstructing Metastasis - Epigenetic Expansion of the VHL-HIF Signal Output Drives Renal Cancer Progression

Dr Sakari Vanharanta, Cancer Biology and Genetics Programme, Memorial Sloan-Kettering Cancer Centre, USA.

Sackler Lecture Theatre, CIMR, Level 7.

Friday 01 March 2013, 14:30-15:30

MRC Cancer Unit Seminars

Exploiting cancer stem cells for the identification of mediators involved in brain tumorigenesis

Dr Rossella Galli, Stem Cell Biology Unit, San Raffaele Scientific Institute, Milan, Italy.

Sackler Lecture Theatre, CIMR, Level 7.

Thursday 28 February 2013, 14:30-15:30

Cancer Research UK Cambridge Institute seminars

Expansion and spread of oncogenic K-ras mutant stem cells throughout the intestinal epithelium

Hugo Snippert (Molecular Cancer Research, University Medical Center, Utrecht).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Tuesday 26 February 2013, 16:00-17:00

Research Seminars - Department of Biochemistry

Title to be confirmed

CANCELLED

Hans Wolf-Watz, University of Umea, Sweden.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 26 February 2013, 13:00-14:00

Gurdon Institute Seminar Series

Controlling gene expression fluctuations during development

Alexander van Oudenaarden, Hubrecht Institute-KNAW & University Medical Center Utrecht, Netherlands.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 26 February 2013, 11:00-12:00

MRC Cancer Unit Seminars

The NCI anticancer drug screen: Cancer through the lens of 60 cell lines

Dr Alexei Vazquez, Department of Radiation Oncology and Cancer Center for Systems Biology, CINJ/UMDNJ-Robert Wood Johnson Medical School, USA.

Sackler Lecture Theatre, CIMR, Level 7.

Friday 22 February 2013, 14:30-15:30

Cancer Research UK Cambridge Institute Seminars in Cancer

Molecular dissection and targeting of epigenetic machinery in AML stem cells

Eric So, Department of Haematological Medicine, King's College London.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 21 February 2013, 13:00-14:00

Research Seminars - Department of Biochemistry

Arrivals and departures: how Arf family G proteins organise membrane traffic at the Golgi

Sean Munro, MRC-LMB, Cambridge.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 19 February 2013, 13:00-14:00

Cambridge Oncology Seminar Series

Challenges in Implementing Personalized Cancer Medicine: the IGR experience

Professor Alexander Eggermont, Director General, Institut de Cancérologie Gustave Roussy, France.

CRI Lecture Theatre.

Tuesday 19 February 2013, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Metabolic regulation of the stress response and the cancer cell's Warburg effect

Markus Ralser (University of Cambridge, Dept of Biochemistry).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 18 February 2013, 16:00-17:00

MRC Cancer Unit Seminars

Mitochondrial oxidative signaling in T cell activation: role for Warburg effect and a new ADP-dependent glucokinase

Marcin Kaminski, German Cancer Research Center (DKFZ), Heidelberg.

Sackler Lecture Theatre, CIMR, Level 7.

Thursday 14 February 2013, 14:30-15:30

Research Seminars - Department of Biochemistry

The CRISPR system for prokaryotic antiviral immunity

Malcolm White, St. Andrews University, UK.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 12 February 2013, 13:00-14:00

MRC Cancer Unit Seminars

What is the epigenetic landscape of the vertebrate kinetochore?

Prof William Earnshaw, Wellcome Trust Centre for Cell Biology, University of Edinburgh.

Sackler Lecture Theatre, CIMR, Level 7.

Wednesday 06 February 2013, 12:00-13:00

Research Seminars - Department of Biochemistry

Ubiquitin signalling in immunity and inflammation - Working on the chain gang

Katrin Rittinger, National Institute for Medical Research, Mill Hill.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 05 February 2013, 13:00-14:00

Cambridge Oncology Seminar Series

Telomeres and the challenges to chromosome integrity

Hutchison/MRC Research Centre Seminar

Dr Julie Cooper, London Research Institute.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 05 February 2013, 12:00-13:00

Gurdon Institute Seminar Series

Immune regulation of vertebrate regeneration

Nadia Rosenthal, National Heart and Lung Institute, Imperial College London; Australian Regenerative Medicine Institute, Monash University; EMBL Australia.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 05 February 2013, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Evolution of cellular networks: from interactions to phenotypes

Pedro Beltrao (EMBL-EBI).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 04 February 2013, 16:00-17:00

Lectures in Cancer Biology

Proteinases and Cancer

Gill Murphy, CRUK Cambridge Research Institute.

CRI Lecture Theatre.

Thursday 31 January 2013, 09:30-10:30

Research Seminars - Department of Biochemistry

The genetics of individuals: why would a mutation kill me, but not you?

Ben Lehner, Centre for Genomic Regulation, Barcelona, Spain.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 29 January 2013, 13:00-14:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Circulating tumour DNA as a biomarker of genetics alterations in cancer

Florent Mouliere (IRCM U896 Inserm, Montpellier, France).

Cancer Research UK Cambridge Institute, Lecture Theatre.

Monday 28 January 2013, 16:00-17:00

Lectures in Cancer Biology

Stem cells and cancer

John Stingl, Cambridge Research Institute.

CRI Lecture Theatre.

Thursday 24 January 2013, 09:30-10:30

Research Seminars - Department of Biochemistry

New insights into old parasites - Plasmodium malariae, P. ovale spp and the mysterious process of host transition.

Colin Sutherland, London School of of Hygiene and Tropical Medicine.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 22 January 2013, 13:00-14:00

Gurdon Institute Seminar Series

Reprogramming and cellular dominance

Amanda Fisher, Imperial College, London.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 22 January 2013, 11:00-12:00

Lectures in Cancer Biology

Estrogen receptor and its role in transcription and breast cancer

Jason Carroll, CRI.

CRI Lecture Theatre.

Thursday 17 January 2013, 09:30-10:30

Cancer Research UK Cambridge Institute seminars

Fundamentals and Applications of Mass Cytometry, using CyTOF

Jane Limer, DVS Sciences.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Wednesday 16 January 2013, 11:00-12:00

MRC Cancer Unit Seminars

Dual role of BubR1 acetylation: Lessons from the acetylation-deficient mice

Dr Hyunsook Lee, Seoul National University.

Sackler Lecture Theatre, CIMR, Level 7.

Monday 14 January 2013, 11:30-12:30

Lectures in Cancer Biology

Microtubules: boring polymers or the Achilles heel of cancer?

Fanni Gergely, CRUK Cambridge Research Institute.

CRI Lecture Theatre.

Thursday 13 December 2012, 09:30-10:30

Cancer Research UK Cambridge Institute Imaging Seminars

Multiparametric MRI of the vasculature: applications to therapy monitoring of gliomas

Chantal Remy, Grenoble Institute of Neurosciences, France.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Wednesday 12 December 2012, 16:30-17:30

Cancer Research UK Cambridge Institute seminars

Molecular pathology: building the backbone of translational research and personalised medicine

Manuel Salto-Tellez, Queens's University Belfast.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Tuesday 11 December 2012, 10:00-11:00

Cambridge Oncology Seminar Series

Localisation-based feedback controls during mitosis and the maintenance of chromosomal stability

Hutchison/MRC Research Centre Seminar

Dr Adrian Saurin, University Medical Center Utrecht, The Netherlands.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 04 December 2012, 12:00-13:00

Gurdon Institute Seminar Series

Unlocking the secrets of scarless wound healing and appendage regeneration

Enrique Amaya, University of Manchester.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 04 December 2012, 11:00-12:00

MRC LMB Seminar list

Assembly and Dynamics of Uber Complex RNPs

Melissa Moore, University of Massachusetts Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 03 December 2012, 16:15-18:00

Cambridge Haematopoiesis Seminars

Epigenetic reprogramming in mammalian development

Wolf Reik.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 30 November 2012, 16:00-17:00

Lectures in Cancer Biology

**Talk postponed** Introduction to statistics

**Talk postponed** Will be rescheduled next year

Sarah Vowler, CRI.

CRI Lecture Theatre.

Thursday 29 November 2012, 09:30-10:30

Research Seminars - Department of Biochemistry

Genetic dissection of the ß-barrel assembly machine in Gram-negative bacteria

Thomas J. Silhavy, Princeton University .

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 27 November 2012, 13:00-14:00

Cambridge Oncology Seminar Series

Cellular responses to DNA damage: translating molecular insights towards new cancer therapies

Prof Steve Jackson, Head of Cancer Research UK Laboratories The Gurdon Institute, Cambridge.

CRI Lecture Theatre.

Tuesday 27 November 2012, 12:00-13:00

Research Seminars - Department of Biochemistry

How the INO80 and PBAF chromatin remodelling complexes function to maintain genome stability

Jessica Downs, MRC Genome Damage and Stability Centre, University of Sussex, Brighton.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 20 November 2012, 13:00-14:00

Cambridge Oncology Seminar Series

Mechanisms of Estrogen Receptor Transcription in Breast Cancer

Dr Jason Carroll, CRUK Cambridge Research Institute.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 20 November 2012, 12:00-13:00

Gurdon Institute Seminar Series

Gene punctuation in eukaryotes: roles of R-loops, gene loops and co-transcriptional cleavage in controlling transcription

Nick Proudfoot, University of Oxford.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 20 November 2012, 11:00-12:00

Cancer Research UK Cambridge Institute Seminars in Cancer

PLEASE NOTE THAT THIS TALK HAS BEEN CANCELLED

Danny Reinberg.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 15 November 2012, 13:00-14:00

Research Seminars - Department of Biochemistry

Synthetic genetic polymers

Philipp Holliger, MRC LMB, Cambridge .

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 13 November 2012, 13:00-14:00

Cambridge Oncology Seminar Series

"Towards personalized medicine in Breast Cancer"

Prof. Dr. Sabine C. Linn, medical oncologist Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

CRI Lecture Theatre.

Tuesday 13 November 2012, 12:00-13:00

Cambridge Oncology Seminar Series

A systems view of the cancer cell: from missing genetic variability to combination therapy

Andrea Califano, Columbia University.

CRI Lecture Theatre.

Wednesday 07 November 2012, 10:30-11:30

Cambridge Oncology Seminar Series

A genomic Odyssey of predicting drug response: is Ulysses home yet?

Dr Federico Innocenti, UNC Institute for Pharmacogenomics and Individualized Therapy.

CRI Lecture Theatre.

Tuesday 06 November 2012, 16:00-17:00

Research Seminars - Department of Biochemistry

Mining RNA-seq Data For Insights into Intron Splicing and Recycling

Will Fairbrother, Department of Molecular and Cellular Biology, Brown University.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 06 November 2012, 13:00-14:00

Cambridge Oncology Seminar Series

Signalling Networks in Cell Proliferation and Fate Control

Hutchison/MRC Research Centre Seminar

Professor Sibylle Mittnacht, UCL Cancer Institute.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 06 November 2012, 12:00-13:00

Gurdon Institute Seminar Series

Lipoproteins and signaling lipids in the Hedgehog pathway

Suzanne Eaton, Max Planck Institute of Molecular Cell Biology & Genetics, Dresden.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 06 November 2012, 11:00-12:00

Research Seminars - Department of Biochemistry

Drug Discovery for Neglected Diseases - Successes, Failures and Lessons Learned

Alan Fairlamb, College of Life Sciences, University of Dundee.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 30 October 2012, 13:00-14:00

Cambridge Haematopoiesis Seminars

The Aging of Hematopoietic Stem Cells

David Bryder, Lund University.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 30 October 2012, 13:00-14:00

Research Seminars - Department of Biochemistry

Enjoying the sun – Macromolecular machines involved in DNA damage detection and repair

Nicolas Thoma, Friedrich Miescher Institute, Basel, Switzerland.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 23 October 2012, 13:00-14:00

Cambridge Haematopoiesis Seminars

Genome-wide mapping of DNA rearrangements in single cells using DNA template strand sequencing

Peter Lansdorp, European Research Institute on the Biology of Ageing, University of Groningen.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 19 October 2012, 16:00-17:00

Research Seminars - Department of Biochemistry

Endosymbiosis, genome mosaicism, and the evolution of photosynthetic eukaryotes

Prof. John Archibald, Department of Biochemistry & Molecular Biology, Dalhousie University, Nova Scotia, Canada.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 16 October 2012, 13:00-14:00

Cambridge Haematopoiesis Seminars

Tet proteins and methylcytosine oxidation

Anjana Rao, La Jolla Institute for Allergy and Immunology.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Monday 15 October 2012, 16:00-17:00

Gurdon Institute Seminar Series

Covert communication in insects

Richard Benton, Center for Integrative Genomics, University of Lausanne.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 09 October 2012, 11:00-12:00

Cancer Research UK Cambridge Institute Seminars in Cancer

The Ras pathway in cancer therapy

Note unusual day

Frank McCormick, UCSF Helen Diller Family Comprehensive Cancer Center.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Wednesday 03 October 2012, 13:00-14:00

MRC Cancer Unit Seminars

Mutant p53 Enhances Receptor Recycling to Promote Invasion and Metastasis

Dr Patricia Muller, Beatson Institute, Glasgow.

Sackler Lecture Theatre, CIMR, Level 7.

Monday 01 October 2012, 14:30-15:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Network biology of cancer

Andrea Califano (Columbia University, New York).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Friday 28 September 2012, 10:30-11:30

MRC Cancer Unit Seminars

Glutamine Metabolism and mTOR Signaling in Cell Growth Regulation

Dr Raul Duran, University of Basel, Switzerland.

Sackler Lecture Theatre, CIMR, Level 7.

Thursday 27 September 2012, 14:30-15:30

MRC Cancer Unit Seminars

RNA Regulatory Networks Help Propagate the Effects of Genetic Alterations

Dr Pavel Sumazin, Center for Computational Biology and Bioinformatics, Columbia University, USA.

Sackler Lecture Theatre, CIMR, Level 7.

Friday 21 September 2012, 14:30-15:30

MRC Cancer Unit Seminars

Epigenetic Regulatory Complexes in Development and Cancer

Dr Peter Mulligan, Harvard University.

Sackler Lecture Theatre, CIMR, Level 7.

Thursday 20 September 2012, 14:30-15:30

Cancer Research UK Cambridge Institute Seminars in Cancer

Challenges in Building a Genomic Prescribing System

Mark J. Ratain, Director, Center for Personalized Therapeutics, University of Chicago.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 20 September 2012, 13:00-14:00

MRC LMB Seminar list

New insights into the role of the chromatin associated factor ATRX

Doug Higgs, MRC Molecular Haematology Unit, Oxford.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 17 September 2012, 11:30-13:00

MRC LMB Seminar list

Max Perutz Lecture 2012: Defective DNA strand break repair, genome instability and cancer

Steve West, CRUK LRI - Clare Hall.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 13 September 2012, 16:15-18:00

Cancer Research UK Cambridge Institute seminars

Functional heterogeneity in intestinal stem cells and cancer

Doug Winton, Cancer Research UK Cambridge Research Institute.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 13 September 2012, 11:45-12:45

Cancer Research UK Cambridge Institute seminars

Niche, signaling, and epigenetic regulation of stem cells

Linheng Li, Stowers Institute for Medical Research.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Wednesday 12 September 2012, 13:00-14:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Lgr5 stem cells in self-renewal and cancer

Please note that this talk is on a Tuesday (joint seminar with the MRC-LMB)

Hans Clevers, Hubrecht Institute, The Netherlands.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Tuesday 11 September 2012, 13:00-14:00

MRC LMB Seminar list

Lgr5 Stem Cells in self-renewal and cancer

Joint lecture with CRI and MRC LMB

Hans Clevers, Hubrecht Institute.

Cambridge Research Institute.

Tuesday 11 September 2012, 13:00-14:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

From protein networks to disease mechanisms

Roded Sharan (Tel-Aviv University).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 10 September 2012, 16:00-17:00

Cambridge Oncology Seminar Series

'Circulating Tumour Cells: Biomarker Utility and Insights to Metastasis'

Professor Caroline Dive, Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, Manchester.

CRI Lecture Theatre.

Tuesday 14 August 2012, 12:00-13:00

MRC Cancer Unit Seminars

The metabolism of hereditary renal cancer

Dr Patrick Pollard, University of Oxford.

Sackler Lecture Theatre, CIMR, Level 7.

Wednesday 01 August 2012, 12:00-13:00

Cancer Research UK Cambridge Institute seminars

How mitotic spindles adapt to the presence/absence of centrosomes

Hélder Maiato, Universidade do Porto, Portugal.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 19 July 2012, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

The role of telomeres and telomerase in stem cell biology, cancer and ageing

Maria Blasco, CNIO, Madrid.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 19 July 2012, 13:00-14:00

MRC Cancer Unit Seminars

Aggressive breast tumors show altered lipid metabolism

Dr Mika Hilvo, VTT Technical Research Centre of Finland.

Sackler Lecture Theatre, CIMR, Level 7.

Wednesday 18 July 2012, 12:00-13:00

MRC LMB Seminar list

Normal and neoplastic stem cells

Irving Weissman, Stanford School of Medicine.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 11 July 2012, 16:15-18:00

MRC Cancer Unit Seminars

Metaplasia and carcinogenesis in stratified epithelia: the role of chronic inflammation

Dr Craig Nowell, EPFL, Switzerland.

Sackler Lecture Theatre, CIMR, Level 7.

Tuesday 03 July 2012, 13:00-14:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Variational Methods in 3+Dimensional Biomedical Imaging

Martin Burger (Uni Münster).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 02 July 2012, 16:00-17:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

The life histories of 21 breast cancers

Peter van Loo (Sanger Institute).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 25 June 2012, 16:00-17:00

MRC LMB Seminar list

Mechanisms for the Selective Degradation of Ubiquitinated Proteins by the 26S Proteasome

Fred Goldberg, Harvard Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 22 June 2012, 16:15-18:00

Cambridge Oncology Seminar Series

Understanding Response & Resistance Mechanisms to Targeted Therapy

Note unusual day and time

Dr Keith Flaherty, Director of Developmental Therapeutics at Massachusetts General Hospital.

CRI Lecture Theatre.

Thursday 21 June 2012, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Cellular Conversations that Control Cell Fate

Thea Tlsty, University of California, San Francisco.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 21 June 2012, 13:00-14:00

MRC LMB Seminar list

Shedding light on Ubiquitin Modification in Cancer.

Vishva Dixit, Genentech.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 12 June 2012, 16:15-18:00

Cambridge Oncology Seminar Series

Cancer-related inflammation

Dr Thorsten Hagemann, Barts Cancer Institute, Queen Mary University of London.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 12 June 2012, 12:00-13:00

Cambridge Oncology Seminar Series

Pancreatic cancer: Genetic models to develop novel diagnostic and therapeutic strategies

Dr Dieter Saur, The Technical University of Munich.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 29 May 2012, 12:00-13:00

MRC LMB Seminar list

The structural and mechanistic basis for Rab cycling and targeting

Roger Goody, MPI Dortmund.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 21 May 2012, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Biological Image Analysis Made Easy

Note the unusual time: 11am not 4pm!

Fred Hamprecht (Heidelberg).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 21 May 2012, 11:00-12:00

MRC LMB Seminar list

Milstein Lecture 2012: How do we sense microbes? From LPS, TNF, and the TLRs.

Bruce Beutler, UT Southwestern Medical Centre.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 17 May 2012, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Common and rare variants in the sequence of the human genome that affect the risk of cancers and other diseases of man

Kari Stefansson, deCODE Genetics, Iceland.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 17 May 2012, 13:00-14:00

Cambridge Oncology Seminar Series

"Strategies to enhance effectiveness of Radiotherapy in Pancreatic Cancer"

Dr Thomas Brunner, Gray Institute for Radiation Oncology and Biology, Oxford.

CRI Lecture Theatre.

Tuesday 15 May 2012, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

The evolution of mammalian tissue transcriptomes

Henrik Kaessmann (Lausanne).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 14 May 2012, 16:00-17:00

Cambridge Haematopoiesis Seminars

Immune cell transdifferentiation

Thomas Graf, Centre for Genomic Regulation (Barcelona).

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 11 May 2012, 16:00-17:00

MRC LMB Seminar list

Monitoring protein synthesis one codon at a time through ribosome profiling

Jonathan Weissman, Howard Hughes Medical Institute, UCSF.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 10 May 2012, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Modeling stem cell differentiation on multiple scales

Tuesday, not Monday!

Fabian Theis (Helmholtz Center Munich).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Tuesday 08 May 2012, 16:00-17:00

Cambridge Oncology Seminar Series

Investigating key effectors downstream of APC (adenomatous polyposis coli) deletion in vivo

Hutchison/MRC Research Centre Seminar

Prof Owen Sansom, Beatson Institute, Glasgow.

Max Perutz Lecture Theatre, MRC LMB.

Tuesday 08 May 2012, 12:00-13:00

Cambridge Oncology Seminar Series

ALK Hunting in Colorado - new drugs for lung cancer's new diseases

Note unusual day and time

Dr Ross Camidge, University of Colorado Hospital (UCH) and the University of Colorado Cancer Center,.

CRI Lecture Theatre.

Thursday 03 May 2012, 17:00-18:00

Cancer Research UK Cambridge Institute seminars

Massively multi-parameter single cell data by Mass Cytometry: the technology of its acquisition and networks for its interpretation

Scott Tanner, University of Toronto and DVS Sciences.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 03 May 2012, 15:00-16:00

MRC LMB Seminar list

Local Translation at the Synapse

Erin Schuman, Max Planck Institute.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 30 April 2012, 16:15-18:00

MRC LMB Seminar list

How end binding proteins recognise growing microtubule ends: from molecular structure to network functioning

Thomas Surrey, Cancer Research UK, London Research Institute.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 26 April 2012, 16:15-18:00

Cambridge Oncology Seminar Series

CANCELLED

Prof Richard Sullivan, Professor, Kings College London, Director, Centre for Global OncoPolicy & Health Kings Health Partners.

CRI Lecture Theatre.

Tuesday 24 April 2012, 12:00-13:00

Cancer Research UK Cambridge Institute seminars

The ETS transcription factor ELF5 and breast cancer phenotype

Chris Ormandy, Garvan Institute, Australia.

Cancer Research UK Cambridge Research Institute, Room 215.

Friday 20 April 2012, 15:00-16:00

Cancer Research UK Cambridge Institute seminars

Gene expression programs controlling ER-negative breast cancer phenotype

Alex Swarbrick, Garvan Institute, Australia.

Cancer Research UK Cambridge Research Institute, Room 215.

Thursday 19 April 2012, 16:15-17:15

MRC LMB Seminar list

Molecular mechanisms of complement activation and regulation

Piet Gros, Utrecht University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 19 April 2012, 14:00-16:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Machine learning applications in genetic regulation and cancer

David Westhead (Leeds).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 16 April 2012, 14:00-15:00

MRC LMB Seminar list

Ubiquitin flips the anaphase switch

David Morgan, UCSF.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 13 April 2012, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Towards unification of genetic and hierarchy models of tumor heterogeneity

Note unusual day

John Dick, University of Toronto.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Wednesday 04 April 2012, 13:00-14:00

MRC LMB Seminar list

John Kendrew Lecture 2012: Harnessing actin dynamics for endocytic trafficking events

David Drubin, Berkeley.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 03 April 2012, 16:15-18:00

Cambridge Oncology Seminar Series

Always on guard: p53 dynamics in single living cells

Hutchison/MRC Research Centre Seminar

Dr Alexander Loewer, Berlin Institute for Medical Systems Biology, Max Delbrueck Center, Germany.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 03 April 2012, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

ShrinkSeq: a flexible and powerful method for Bayesian analysis of RNAseq data

Note the time change: 2pm (not 4pm)

Mark van de Wiel (VU University Medical Center).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 02 April 2012, 14:00-15:00

Cambridge Oncology Seminar Series

"Exploiting ASS1 deficiency in the treatment of mesothelioma"

Dr Peter Szlosarek, Cancer Research UK Clinician Scientist, Senior Lecturer and Honorary Consultant in Medical Oncology, Barts and The London.

Seminar Room 2, Clinical School, Addenbrooke’s.

Tuesday 27 March 2012, 11:30-13:00

Cambridge Haematopoiesis Seminars

Local interactions and genome-wide co-associations of proto-oncogenes: the short and the long of it.

Cameron Osborne, Babraham Institute.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 23 March 2012, 16:00-17:00

Lectures in Cancer Biology

Clinical drug resistance in ovarian cancer

James Brenton, CRUK Cambridge Research Institute.

CRI Lecture Theatre.

Thursday 22 March 2012, 09:30-10:30

Cambridge Oncology Seminar Series

"Thalidomide and its analogues ; How molecules selected for anti-TNFa activity affect so many different pathways with direct binding with Cereblon mediating both anti proliferative and Immunomodulatory functions"

Individuals who are interested in meeting with any of the speakers should contact me asap. Thanks, Jonathan (jlh66@cam.ac.uk)

Jerome B. Zeldis CEO of Celgene Global Health & Angus Dalgleish, St George's Hospital London.

CRI Lecture Theatre.

Tuesday 20 March 2012, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Evolution of developmental gene expression programs

Itai Yanai (Technion).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 19 March 2012, 16:00-17:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Pluripotency, Etc.

Ihor Lemischka, Mount Sinai Medical Centre.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 15 March 2012, 13:00-14:00

Lectures in Cancer Biology

Clinical lectures on prostate, bladder, renal and testis cancer

David Neal, Cancer Research UK Cambridge Research Institute.

CRI Lecture Theatre.

Thursday 15 March 2012, 09:30-10:30

Research Seminars - Department of Biochemistry

Drugging the cancer genome

CANCELLED due to illness

Prof. Paul Workman, Institute of Cancer Research, Surrey.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 13 March 2012, 13:00-14:00

Cambridge Oncology Seminar Series

"Re Service Reforms in the new Commissioning Landscape"

Hannah Farrar, Director of Strategy and System Management, NHS, London.

CRI Lecture Theatre, Cambridge Research Institute.

Tuesday 13 March 2012, 12:00-13:00

MRC LMB Seminar list

A Chemicogenetic approach to DNA repair implicates TORC2 and actin in survival of DNA breaks

Susan Gasser, Friedrich Miescher Institute for Biomedical Research.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 12 March 2012, 16:15-18:00

MRC LMB Seminar list

Disruptions on the Highways of Cell Communication

Dario Alessi, MRC Protein Phosphorylation Unit, University of Dundee.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 06 March 2012, 16:15-18:00

Gurdon Institute Seminar Series

Dosage compensation: An intertwined world of RNA and chromatin remodeling

Asifa Akhtar, Max Planck Institute of Immunobiology & Epigenetics, Freiburg, Germany.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 06 March 2012, 11:45-12:45

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Modelling in systems genetics: computational approaches for discovering disease networks

Tom Michoel (FRIAS Freiburg).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 05 March 2012, 16:00-17:00

Research Seminars - Department of Biochemistry

Interactome Networks and Human Disease

Alkis Seraphim memorial lecture

Marc Vidal, Dana-Farber Cancer Institute, Harvard Medical School.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Thursday 01 March 2012, 17:00-18:00

Research Seminars - Department of Biochemistry

The architecture and ppGpp-dependent expression of the primary transcriptome of Salmonella Typhimurium

Dr. Arthur Thompson, Institute of Food Research, Norwich.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 28 February 2012, 13:00-14:00

Cambridge Oncology Seminar Series

"DICER1 and miRNA processing - a novel paradigm in cancer predisposition"

Dr Marc Tischkowitz, Dept of Medical Genetics, University of Cambridge.

CRI Lecture Theatre.

Tuesday 28 February 2012, 12:00-13:00

Cancer Research UK Cambridge Institute seminars

Why 90% of novel anticancer agents are ineffective in clinical trial – and what to do about it

John Hickman, Coordinator, EU Innovative Medicines Initiative PREDECT, Paris.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Friday 24 February 2012, 09:30-10:30

Cancer Research UK Cambridge Institute seminars

Cellular senescence as both a dynamic and a static phenotype

Masashi Narita, Cambridge Research Institute.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 23 February 2012, 10:00-11:00

Lectures in Cancer Biology

Functional breast cancer genomics: from basic biology to clinical application

**Talk postponed**

Carlos Caldas, CRI.

CRI Lecture Theatre.

Thursday 23 February 2012, 09:30-10:30

Cambridge Oncology Seminar Series

"Myeloproliferative neoplasms – JAK/STAT signalling and stem cell subversion"

Prof Tony Green, University of Cambridge Department of Haematology.

CRI Lecture Theatre.

Tuesday 21 February 2012, 12:00-13:00

Gurdon Institute Seminar Series

Dynamics of Dpp signaling and proliferation control

Marcos Gonzalez-Gaitan, Depts of Biochemistry & Molecular Biology, University of Geneva, Switzerland.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 21 February 2012, 11:45-12:45

MRC LMB Seminar list

Structural and Biochemical Mechanisms of Synchronous Synaptic Transmission

James Rothman, Yale University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 21 February 2012, 11:30-18:00

Cancer Research UK Cambridge Institute Imaging Seminars

Developing imaging approaches for novel cancer therapies

Eric Aboagye, Imperial College, London.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Friday 17 February 2012, 13:00-14:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Chromosome Segregation and Genome Stability

David Pellman, Dana-Farber Cancer Institute, Harvard Medical School.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 16 February 2012, 13:00-14:00

Lectures in Cancer Biology

Imaging tumour responses to treatment

Kevin Brindle, Dept. Biochemistry and Cambridge Research Institute.

CRI Lecture Theatre.

Thursday 16 February 2012, 09:30-10:30

MRC LMB Seminar list

Crick Lecture 2012: Consequences of Aneuploidy

Angelika Amon, HHMI, MIT.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 15 February 2012, 16:15-18:00

Research Seminars - Department of Biochemistry

HOW MUCH CAN ONE SEE BY (JUST) LOOKING: the case with Heterochromatin Protein 1

Prof. Spyros Georgatos, University of Iannina, Greece.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 14 February 2012, 13:00-14:00

Cambridge Oncology Seminar Series

"Radiotherapy toxicity, Radiogenomics and RAPPER"

Dr Gill Barnett, Dept. of Oncology.

CRI Lecture Theatre.

Tuesday 14 February 2012, 12:00-13:00

MRC Cancer Unit Seminars

Centrosome Amplification: Cancer’s Friend or Foe?

Dr Susana Godinho, Dana-Farber Cancer Institute.

Sackler Lecture Theatre, CIMR, Level 7.

Wednesday 08 February 2012, 12:00-13:00

Cambridge Oncology Seminar Series

Transcriptional control of EMT and malignant tumor progression

Hutchison/MRC Research Centre Seminar

Prof Gerhard Christofori, University of Basel, Switzerland.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 07 February 2012, 12:00-13:00

Gurdon Institute Seminar Series

THIS SEMINAR HAS BEEN CANCELLED

Suzanne Eaton, Max Planck Institute of Molecular Cell Biology & Genetics, Dresden, Germany.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 07 February 2012, 11:45-12:45

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Model Based Target Identification from Expression Data

Neil Lawrence (University of Sheffield).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 06 February 2012, 16:00-17:00

Hutchison/MRC Research Centre Seminars

Nischarin, a novel tumor suppressor of breast cancer

Prof Suresh K. Alahari, Stanley S. Scott Cancer Center, Louisiana State University, USA..

Sackler Lecture Theatre, CIMR, Level 7.

Monday 06 February 2012, 14:00-15:00

MRC LMB Seminar list

New concepts in host-pathogen interactions: lessons from Listeria

Pascale Cossart, Institute Pasteur, Paris.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 02 February 2012, 16:15-18:00

Cancer Research UK Cambridge Institute seminars

A STAT3‐induced metabolic switch involved in tumour transformation mediates STAT3 addiction

Valeria Poli, University of Turin.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 02 February 2012, 15:00-16:00

Lectures in Cancer Biology

MRI and MRS in cancer research and cancer treatment

John Griffiths, Cambridge Research Institute.

CRI Lecture Theatre.

Thursday 02 February 2012, 09:30-10:30

Research Seminars - Department of Biochemistry

Molecular mechanisms of the Polycomb/trithorax system

Dr. Juerg Mueller, Department of Chromatin and Chromosome Biology, Max Planck Institute of Biochemistry, Munich, Germany.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 31 January 2012, 13:00-14:00

Cambridge Haematopoiesis Seminars

How do enhancers and promoters interact and what are the consequences ?

Doug Higgs, Weatherall Institute, Oxford,.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 27 January 2012, 16:00-17:00

Research Seminars - Department of Biochemistry

Structural basis of anaphase promoting complex assembly, substrate recognition and regulation by the mitotic checkpoint complex

Prof. David Barford, Institute of Cancer Research, London.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 24 January 2012, 13:00-14:00

Cambridge Oncology Seminar Series

“Imaging Biomarkers in Cancer”

Prof. Fiona Gilbert, Dept. of Radiology.

Sackler Lecture Theater on level 7 of the CIMR (Cambridge Institute for Medical Research).

Tuesday 24 January 2012, 12:00-13:00

Gurdon Institute Seminar Series

Multiscale dynamics in zebrafish gastrulation

Nadine Peyrieras, CNRS-NED, Institute of Neurobiology, Gif-sur-Yvette, France.

Biffen Lecture Theatre, Department of Genetics, Downing Site.

Tuesday 24 January 2012, 11:45-12:45

MRC LMB Seminar list

Functions of Dynamin A, Myosin IB and WASH in phagolysosome biogenesis, and the Exocyst in kiss-and-run exocytosis in Dictyostelium

Thierry Soldati, University of Geneva.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 23 January 2012, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Inflammatory skin disease and Cancer: Functions of AP-1 (Fos/Jun) in mice and humans

Erwin Wagner, CNIO Madrid.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 19 January 2012, 13:00-14:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

The Search for Organizing Principles in Cancer Systems Biology

Olaf Wolkenhauer (University of Rostock, www.sbi.uni-rostock.de).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 16 January 2012, 16:00-17:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Increased methylation variation across cancer types

Kasper Daniel Hansen (Johns Hopkins).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Friday 13 January 2012, 16:00-17:00

MRC LMB Seminar list

Signaling through the ubiquitin system

Wade Harper, Harvard Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 15 December 2011, 16:15-18:00

Cambridge Oncology Seminar Series

Neo-adjuvant radiochemotherapy in breast cancer

Dr Alain Fourquet, Department of Radiation Oncology, Institut Curie, Paris.

CRI Lecture Theatre.

Tuesday 13 December 2011, 12:00-13:00

Cancer Research UK Cambridge Institute Seminars in Cancer

*CANCELLED* Wnt signalling, Lgr5 stem cells and cancer

**This seminar has been cancelled**

Hans Clevers, Hubrecht Institute.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 08 December 2011, 13:00-14:00

Cambridge Haematopoiesis Seminars

Commitment and plasticity in the B cell lineage

Research Institute of Molecular Pathology Vienna, Austria.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 06 December 2011, 16:00-17:00

Cambridge Oncology Seminar Series

Integration of Cell Growth and Cell Metabolism by Myc

Hutchison/MRC Research Centre Seminar

Prof Martin Eilers, Theodor-Boveri-Institute, University of Würzburg, Germany.

Sackler Lecture Theatre, CIMR, Level 7.

Tuesday 06 December 2011, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

RNAi libraries for high throughput phenotyping and drug resistance screening in the African trypanosome

David Horn (LSHTM).

Cancer Research UK Cambridge Research Institute, Room 215.

Monday 05 December 2011, 16:00-17:00

Cancer Research UK Cambridge Institute seminars

Novel risk biomarkers based on DNA repair for early detection and prevention of lung cancer.

Zvi Livneh, Weizmann Institute of Science.

Cancer Research UK Cambridge Research Institute, Room 215.

Monday 05 December 2011, 10:30-11:30

MRC Cancer Unit Seminars

From gene regulation to cancer - arginine methylation makes its mark

Dr Clare Davies, University of Manchester.

Sackler Lecture Theatre, CIMR, Level 7.

Thursday 01 December 2011, 14:30-15:30

Lectures in Cancer Biology

Cancer Therapeutics

Duncan Jodrell, Cambridge Research Institute and Department of Oncology.

CRI Lecture Theatre.

Thursday 01 December 2011, 09:30-10:30

Research Seminars - Department of Biochemistry

Protease-mediated protein processing and the "forgotten" co-translational alpha-N-acetylation revealed by positional proteomics

Please note - CANCELLED due to illness

Prof. Kris Gevaert, VIB Life Science Research Institute, Gent, Belgium.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 29 November 2011, 13:00-14:00

Gurdon Institute Seminar Series

Genomic encoding of shape in ascidian embryos

Patrick Lemaire, CRBM, Montpellier, France.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 29 November 2011, 11:45-12:45

MRC LMB Seminar list

Structural and Mechanistic Studies of the Anaphase Promoting Complex

David Barford, Institute of Cancer Research.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 24 November 2011, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

RNAi-based molecular computing for cancer cell detection

Yaakov (Kobi) Benenson (ETH Zurich BSSE).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 21 November 2011, 16:00-17:00

MRC Cancer Unit Seminars

Modeling Minimal Residual Disease and Acquired Cancer Drug Resistance in vitro

Sreenath Sharma, Novartis Institutes for BioMedical Research, USA.

Sackler Lecture Theatre, CIMR, Level 7.

Friday 18 November 2011, 14:30-15:30

MRC Cancer Unit Seminars

Pyruvate kinase M2 and cancer metabolism

Dimitris Anastasiou, Beth Israel Deaconess Medical Center, Harvard Medical School, USA.

Sackler Lecture Theatre, CIMR, Level 7.

Thursday 17 November 2011, 14:30-15:30

Cancer Research UK Cambridge Institute Seminars in Cancer

The intrinsic and extrinsic regulation of stem cells self-renewal

Sean J Morrison, Children’s Research Institute, University of Texas Southwestern Medical Center.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 17 November 2011, 13:00-14:00

MRC LMB Seminar list

The Evolution of Enzyme Mechanisms and Functional Diversity

Janet Thornton, EMBL-EBI.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 15 November 2011, 16:15-18:00

Research Seminars - Department of Biochemistry

The Spliceosome: the machine that removes introns from pre-mRNA

Kiyoshi Nagai, MRC LMB, Cambridge.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 15 November 2011, 13:00-14:00

Gurdon Institute Seminar Series

Stem cells, cell-cell interactions, and homeostasis in the Drosophila intestine

Bruce Edgar, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 15 November 2011, 11:45-12:45

Cancer Research UK Cambridge Institute seminars

Drug resistance and disease progression: lessons from prostate cancer

Charles Sawyers, Memorial Sloan Kettering Cancer Centre.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 10 November 2011, 13:00-14:00

Lectures in Cancer Biology

Barrett's oesophagus as a model for early cancer detection/treatment

Rebecca Fitzgerald, Hutchison/MRC Research Centre.

CRI Lecture Theatre.

Thursday 10 November 2011, 09:30-10:30

Research Seminars - Department of Biochemistry

Protein/Lipid Interactions in Membranes via Multiscale Simulations

Prof. Mark Sansom, Department of Biochemistry, University of Oxford.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 08 November 2011, 13:00-14:00

Gurdon Institute Seminar Series

Guidance mechanisms in collective cell migration

Pernille Rorth, Institute of Molecular & Cell Biology, Singapore.

Biffen Lecture Theatre, Department of Genetics, Downing Site.

Tuesday 08 November 2011, 11:30-12:30

Cambridge Haematopoiesis Seminars

Long non-coding and extracoding RNAs in normal haematopoiesis and leukemia

Dan Tenen, Cancer Science Institute of Singapore and Harvard Medical School.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Monday 07 November 2011, 16:00-17:00

MRC Cancer Unit Seminars

Mechanisms and regulation of centrosome biogenesis

Jay Gopalakrishnan, Harvard University, USA.

Sackler Lecture Theatre, CIMR, Level 7.

Monday 07 November 2011, 11:00-12:00

MRC Cancer Unit Seminars

RB collaborators in cancer

David MacPherson, Carnegie Institution, Baltimore, USA.

Sackler Lecture Theatre, CIMR, Level 7.

Thursday 03 November 2011, 15:00-16:00

MRC Cancer Unit Seminars

The story of the intracellular recycling factory- mTOR autophagy spatial coupling compartment (TASCC) augments secretory phenotypes

Andy Young, CRUK Cambridge Research Institute.

Sackler Lecture Theatre, CIMR, Level 7.

Wednesday 02 November 2011, 12:00-13:00

Research Seminars - Department of Biochemistry

New biological insights from single molecule experiments

Prof. David Klenerman, Department of Chemistry, Cambridge.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 01 November 2011, 13:00-14:00

Cambridge Oncology Seminar Series

Cancer Gene Discovery in the Mouse

Hutchison/MRC Research Centre Seminar

Dr David Adams, Wellcome Trust Sanger Institute.

Max Perutz Lecture Theatre, MRC LMB.

Tuesday 01 November 2011, 12:00-13:00

MRC LMB Seminar list

Structural Studies on the Regulation of Protein Kinases: EGFR and CamK-II

John Kuriyan, HHMI, University of California, Berkeley.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 31 October 2011, 16:15-18:00

MRC LMB Seminar list

Neuronal plasticity: from synapses to the axon initial segment

Juan Burrone, Kings College London.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 28 October 2011, 16:15-18:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Inferring mechanisms of gene regulation from patterns of evolutionary divergence

Itay Tirosh (Weizmann Institute).

Cancer Research UK Cambridge Research Institute, Room 215.

Wednesday 26 October 2011, 16:00-17:00

Research Seminars - Department of Biochemistry

Title to be confirmed

Prof. Matthias Mann, Department of Proteomics and Signal transduction, Max Planck Institute of Biochemistry, Munich, Germany.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 25 October 2011, 13:00-14:00

MRC Cancer Unit Seminars

Metabolic synthetic lethality as a new strategy for cancer therapy

Christian Frezza, Beatson Institute for Cancer Research, Glasgow.

Sackler Lecture Theatre, CIMR, Level 7.

Tuesday 25 October 2011, 12:00-13:00

Cancer Research UK Cambridge Institute seminars

The use of cell lines – promises and pitfalls

Ian Freshney, Cancer Research UK Centre for Oncology and Applied Pharmacology, University of Glasgow.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Tuesday 25 October 2011, 10:30-11:30

Cancer Research UK Cambridge Institute Seminars in Cancer

Transcriptional Regulation of Cell State

Richard Young, Whitehead Institute for Biomedical Research and M.I.T..

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 20 October 2011, 13:00-14:00

Research Seminars - Department of Biochemistry

The functional significance of the modular architecture of plant cell wall degrading enzymes

Prof. Harry J. Gilbert, School of Biomedical Sciences, Newcastle University.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 18 October 2011, 13:00-14:00

Cambridge Oncology Seminar Series

‘Genetic predisposition to cancer’

Prof Bruce Ponder, Cancer Research UK Cambridge Research Institute.

CRI Lecture Theatre.

Tuesday 18 October 2011, 12:00-13:00

Gurdon Institute Seminar Series

The genetics of cell competition and synthetic species

Eduardo Moreno, Institute of Cell Biology, University of Bern, Switzerland.

Biffen Lecture Theatre, Department of Genetics, Downing Site.

Tuesday 18 October 2011, 11:30-12:30

Research Seminars - Department of Biochemistry

Mass spectrometric analysis of lipid signalling in cancer

Prof. Michael J. O. Wakelam, Babraham Institute.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 11 October 2011, 13:00-14:00

Cancer Research UK Cambridge Institute seminars

Regulation of tumour adaptability in endocrine resistant breast cancer

Leonie Young, Royal College of Surgeons, Dublin.

Cancer Research UK Cambridge Research Institute, Room 215a.

Tuesday 11 October 2011, 11:00-12:00

MRC LMB Seminar list

DNA-dependent protein kinase is a DNA sensor for IRF-3-dependent innate immunity

Geoffrey Smith, Department of Pathology Cambridge.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 06 October 2011, 16:15-18:00

Cancer Research UK Cambridge Institute seminars

So what is the real function of chromatin?

David Bazett-Jones: Senior Scientist, The Hospital for Sick Children, Professor, Department of Biochemistry, University of Toronto.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Tuesday 04 October 2011, 13:00-14:00

Cambridge Oncology Seminar Series

Tumour-stroma Interactions in Breast Cancer

Hutchison/MRC Research Centre Seminar

Prof Clare Isacke, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research.

Sackler Lecture Theatre, CIMR, Level 7.

Tuesday 04 October 2011, 12:00-13:00

Gurdon Institute Seminar Series

Reproductive organ development in the mouse

Richard Behringer, Dept of Genetics, University of Texas, USA.

Biffen Lecture Theatre, Department of Genetics, Downing Site.

Tuesday 04 October 2011, 11:30-12:30

Cancer Research UK Cambridge Institute seminars

Translational Cancer Genomics Research

Affymetrix.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Tuesday 04 October 2011, 11:00-12:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Chromatin-mediated regulation of gene expression in mouse ES cells

Helle Jørgensen (University of Cambridge).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 03 October 2011, 16:00-17:00

MRC LMB Seminar list

mRNA-tRNA translocation intermediates by cryo-EM: a look at the free-energy landscape from a single sample.

Joachim Frank, Columbia University.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 30 September 2011, 16:15-18:00

Cambridge Haematopoiesis Seminars

Chromatin, chromosome and nuclear dynamics, links to genome function

Peter Fraser, Babraham Institute.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 23 September 2011, 16:00-17:00

Cambridge Oncology Seminar Series

DNA repair inhibitors in cancer treatment

Prof Hilary Calvert, UCL Cancer Institute.

CRI Lecture Theatre.

Tuesday 20 September 2011, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Adult stem cell fate: a laboratory for statistical physics

Ben Simons (University of Cambridge).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 19 September 2011, 16:00-17:00

MRC LMB Seminar list

Molecular and cellular mechanisms for memory allocation in neuronal networks

Alcino Silva, UCLA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 16 September 2011, 16:15-18:00

Cambridge Haematopoiesis Seminars

Genome-wide DNA methylation analysis in stem cells and cancer

Christoph Bock, Broad Institute.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 16 September 2011, 16:00-17:00

MRC LMB Seminar list

Genetic dissection of emotion circuits in flies and mice - Francis Crick Lecture 2011

Dr David Anderson, California Institute of Technology, USA.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 09 September 2011, 16:00-18:00

Cambridge Oncology Seminar Series

Haploid Genetic Screens in Human Cells

Hutchison/MRC Research Centre Seminar

Dr Thijn Brummelkamp, Netherlands Cancer Institute.

Max Perutz Lecture Theatre, MRC LMB.

Tuesday 06 September 2011, 12:00-13:00

Cancer Research UK Cambridge Institute seminars

HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 Herceptin in breast cancer

Anthony Kong, Weatherall Institute of Molecular Medicine, University of Oxford.

Cancer Research UK Cambridge Research Institute, Room 215.

Thursday 25 August 2011, 12:00-13:00

MRC LMB Seminar list

Self-assembled DNA-nanostructure tools for molecular biophysics

William Shih, Harvard Medical School.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monday 25 July 2011, 16:15-18:00

MRC LMB Seminar list

PDBe - Bringing Structure to Biology

Gerard Kleywegt, EMBL-EBI.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 14 July 2011, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Modeling non-familial colon cancer susceptibility in mice

David Threadgill, Department of Genetics, North Carolina State University.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 14 July 2011, 13:00-14:00

MRC LMB Seminar list

Tuberculosis Treatment Dicta from the Zebrafish

Lalita Ramakrishnan, University of Washington.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 07 July 2011, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Integrated Solutions in Cancer Genomics

Edison Liu, Genome Institute of Singapore.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 07 July 2011, 13:00-14:00

Cambridge Haematopoiesis Seminars

Development of hematopoietic stem cells: an outline of the final scenario

Shin-Ichi Nishikawa, Riken CDB, Kobe.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Wednesday 06 July 2011, 10:00-11:00

Cancer Research UK Cambridge Institute seminars

Learnings from kinase inhibitors for cancer therapy

Gideon Bollag (Senior Vice President of Research for Plexxikon Inc., California).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Friday 01 July 2011, 16:00-17:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Perturbation Biology of Cancer Cells

Chris Sander (MSKCC).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Wednesday 29 June 2011, 15:00-16:00

Cambridge Oncology Seminar Series

The ATM-mediated DNA damage response: moving between the forest and the trees

Hutchison/MRC Research Centre Seminar

Dr Yossi Shiloh, Tel Aviv University, Israel.

Sackler Lecture Theatre, CIMR, Level 7.

Tuesday 28 June 2011, 12:00-13:00

Cancer Research UK Cambridge Institute seminars

Progress towards a biomarker discovery-to-development pipeline in clinical proteomics

Michael Gillette, Broad Institute of MIT and Harvard.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 27 June 2011, 13:00-14:00

MRC LMB Seminar list

Autoantibodies against NMDA receptors and other neuronal targets: the widening spectrum of antibody-mediated CNS disorders

Angela Vincent, University of Oxford.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 22 June 2011, 14:30-16:15

Cambridge Oncology Seminar Series

‘Viral and host contributions to cervical carcinogenesis’

Dr Nick Coleman, Department of Pathology & Hutchison/MRC Research Centre.

CRI Lecture Theatre.

Tuesday 21 June 2011, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Phylogenetic Inference of Multidomain Evolution

Dannie Durand (Carnegie Mellon University, Pittsburgh).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 20 June 2011, 16:00-17:00

Cambridge Haematopoiesis Seminars

Why do we need a Fanconi Anaemia DNA repair pathway?

KJ Patel, MRC LMB, Cambridge.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 17 June 2011, 16:00-17:00

MRC LMB Seminar list

Exploring and exploiting chromosome repair and segregation mechanisms in cancer

Ashok Venkitaraman, MRC Cancer Cell Unit.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 16 June 2011, 16:15-18:00

Cancer Research UK Cambridge Institute Seminars in Cancer

Changing Cancer Mortality

Richard Peto, Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 16 June 2011, 13:00-14:00

Cambridge Oncology Seminar Series

"Advances in Head and Neck Radiotherapy"

Dr Chris Nutting, Royal Marsden Hospital.

CRI Lecture Theatre.

Tuesday 14 June 2011, 12:00-13:00

Cambridge Haematopoiesis Seminars

Genetics and therapy of AML: role of mutations in the epigenetic machinery

Ross Levine, Memorial Sloan-Kettering, New York.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Thursday 09 June 2011, 13:30-14:30

Cambridge Oncology Seminar Series

"Developing Medicines for Pancreatic Cancer"

Dr Dave Tuveson, CRUK Cambridge Research Institute.

CRI Lecture Theatre.

Tuesday 07 June 2011, 12:00-13:00

Cancer Research UK Cambridge Institute seminars

Metabolomic Studies of Cancer Using 13C Tracer Substrates and Model Fitting

Laszlo G Boros, Associate Professor of Paediatrics, UCLA School of Medicine, and Chief Scientist, SiDMAP LLC, Los Angeles, USA.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 02 June 2011, 17:00-18:00

MRC LMB Seminar list

Visualizing vesicle and virus budding by electron microscopy

John Briggs, EMBL.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Wednesday 01 June 2011, 11:30-13:15

Cambridge Oncology Seminar Series

SOCCAR trial: an update

Dr Joe Maguire, Consultant Clinical Oncologist, Clatterbridge Centre for Oncology.

CRI Lecture Theatre.

Tuesday 31 May 2011, 12:00-13:00

Lectures in Cancer Biology

Genomic Imprinting and Cancer

Adele Murrell, CRUK Cancer Research Institute.

CRI Lecture Theatre.

Thursday 26 May 2011, 09:30-10:30

Cambridge Oncology Seminar Series

“What lessons can we learn from transcriptional evolution in cancer research?”

Dr Duncan Odom, CRUK Cambridge Research Institute.

CRI Lecture Theatre.

Tuesday 24 May 2011, 12:00-13:00

MRC LMB Seminar list

Genetic Architecture of Leukaemia

Mel Greaves, Institute of Cancer Research.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 19 May 2011, 16:15-18:00

Cancer Research UK Cambridge Institute seminars

Haloplex technology: a genome capture system for next generation sequencing

Olle Ericsson, Halo Genomics.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 19 May 2011, 14:30-15:30

MRC LMB Seminar list

Delivery Boy to Reporter: Unusual DNA’s journey through a worm-whole

Yamuna Krishnan, National Centre for Biological Sciences Bangalore.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 17 May 2011, 16:15-18:00

Cambridge Oncology Seminar Series

CANCELLED

Prof. Roy Rampling, University of Glasgow and The Beatson Cancer Centre, Glasgow.

CRI Lecture Theatre.

Tuesday 17 May 2011, 12:00-13:00

Seminars on Quantitative Biology @ CRUK Cambridge Institute

Allele specific expression design using short read DNA sequencing and application to the genetics of autoimmune disorders

Vincent Plagnol (UCL).

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 16 May 2011, 16:00-17:00

Cambridge Haematopoiesis Seminars

The development of HSCs: endothelial to hematopoietic transition

Elaine Dzierzak, Erasmus MC, Rotterdam.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 13 May 2011, 16:00-17:00

MRC LMB Seminar list

A primer on DNA origami and why molecular biologists might care

Hendrik Dietz, TU Munich.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 12 May 2011, 16:15-18:00

Cambridge Oncology Seminar Series

"Multi-site post-translational modification as a quantitative regulator of transcriptional output during neurogenesis"

Dr Anna Philpott, Department of Oncology, MRC-Hutchison Research Centre.

CRI Lecture Theatre.

Tuesday 10 May 2011, 12:00-13:00

MRC LMB Seminar list

Genome-wide analysis of AID activity and AID-mediated translocations in B lymphocytes

Rafael Casellas, NIH.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 06 May 2011, 16:15-18:00

Cambridge Oncology Seminar Series

CANCELLED

Hutchison/MRC Research Centre Seminar

Prof Sibylle Mittnacht, The Institute of Cancer Research.

Sackler Lecture Theatre, CIMR, Level 7.

Tuesday 03 May 2011, 12:00-13:00

Gurdon Institute Seminar Series

The developmental biology toolbox in basic and translational studies

Chris Wylie.

Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Tuesday 03 May 2011, 11:30-12:30

Cambridge Oncology Seminar Series

CANCELLED

Dr Vincent Gnanapragasam, Hutchison/MRC Research Centre & Addenbrooke's Hospital.

CRI Lecture Theatre.

Tuesday 26 April 2011, 12:00-13:00

Cancer Research UK Cambridge Institute Imaging Seminars

Genes into Geometry: Imaging for mouse phenotyping

Mark Henkelman, Department of Medical Biophysics and Medical Imaging, University of Toronto.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Thursday 21 April 2011, 13:00-14:00

Cambridge Haematopoiesis Seminars

Studying precancerous stem cells in mouse models of T cell leukaemia

Matthew McCormack, WEHI, Melbourne.

Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Monday 18 April 2011, 10:30-11:30

Seminars on Quantitative Biology @ CRUK Cambridge Institute

CRUK computational biology day

Speaker to be confirmed.

Cancer Research UK Cambridge Research Institute, Lecture Theatre.

Monday 18 April 2011, 09:00-17:00

MRC LMB Seminar list

Feldberg Prize Lecture: Biogenesis of iron-sulfur proteins in eukaryotes

Professor Roland Lill, Philipps University Marburg, Germany.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Friday 15 April 2011, 16:15-18:00

MRC LMB Seminar list

Controlling Recombination

Simon Boulton, CRUK Clare Hall Laboratories.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Thursday 14 April 2011, 16:15-18:00

Lectures in Cancer Biology

Signal transduction and membrane trafficking

Ian Mills, CRUK Cambridge Research Institute.

CRI Lecture Theatre.

Thursday 14 April 2011, 09:30-10:30

MRC LMB Seminar list

A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae

Anne-Claude Gavin, EMBL.

Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuesday 12 April 2011, 16:15-18:00