Statistical challenges posed by heterogeneous data from immunology and microbiology- CANCELLED

Add to your list(s) Download to your calendar using vCal

• Professor Susan Holmes from Stanford University
• Monday 16 March 2020, 13:00-14:00
• CRUK CI Lecture Theatre (Room 001).

If you have a question about this talk, please contact Anna Toporska.

The human microbiome is a complex assembly of bacteria that are sensitive to many perturbations. Subject to subject differences are the primary source of variation. Thus carefully designed perturbation experiments using longitudinal sampling provide the best approach for discovering the main drivers of resilience and recovery. Prof Holmes and her collaborators have developed specific tools for studying the vaginal, intestinal and oral microbiomes under different perturbations (pregnancy, hypo-salivation inducing medications and antibiotics are some examples). In her talk, prof Holmes will show how the tools use hierarchical nonparametric geometric and network-based methods. Challenges that have been addressed include information leaks, the integration of phylogenetic information, testing in the presence of longitudinal dependencies and uncertainty quantification. The methods enable the detection of changepoints, ecological gradients and their uncertainty quantification, as well as the integration of tree-aware multivariate representations. This contains joint work with Lan Huong Nguyen, Pratheepa Jeganathan, Claire Donnat, Sergio Bacallado, Ben Callahan, Julia Fukuyama, Christof Seiler, Kris Sankaran and David Relman’s Lab.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

This talk is included in these lists:

• All CMS Events
• All Talks (aka the CURE list)
• Biology
• CCC talks for website
• CRUK CI Lecture Theatre (Room 001)
• CRUK CI Seminars
• CamBridgeSens
• Cambridge Centre for Data-Driven Discovery (C2D3)
• Cambridge talks
• Chris Davis' list
• Computational and Systems Biology
• Graduate-Seminars
• Interested Talks
• Liam
• Life Science Interface Seminars
• Life Sciences
• Life Sciences
• ME Seminar
• PMRFPS's
• School of Physical Sciences
• Seminars on Quantitative Biology @ CRUK Cambridge Institute
• Trust & Technology Initiative - interesting events
• bld31
• custom
• my_list
• ndk22's list
• ob366-ai4er
• other talks
• rp587
• se393's list
• sfm36

Note that ex-directory lists are not shown.