Cell size - A new hallmark of aging?

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• Jette Lengefeld, University of Helsinki and Karolinska Institute
• Monday 26 February 2024, 12:30-13:30
• CRUK CI Lecture Theatre.

If you have a question about this talk, please contact Kate Davenport.

Years of important research has revealed that cells heavily invest in regulating their size. Nevertheless, it has remained unclear why accurate size control is so important. Our recent study using hematopoietic stem cells (HSCs) in vivo indicates that cellular enlargement is causally associated with aging. I present an overview of these findings and their implications. Furthermore, I present a broad literature analysis to evaluate the potential of cellular enlargement as a new aging hallmark and I highlight interesting work showing a correlation between cell size and age-related diseases. Taken together, I will present mounting evidence linking cellular enlargement to aging and age-related diseases.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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